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2 results on '"Pranay R. Randad"'

1. Author Correction: Comparison of livestock-associated and community-associated Staphylococcus aureus pathogenicity in a mouse model of skin and soft tissue infection

Author

Karen C. Carroll, Roger V. Ortines, Pranay R. Randad, David W. Mohr, Lance B. Price, Lloyd S. Miller, Christopher D. Heaney, Jesper Larsen, Tara C. Smith, Hülya Kaya, Carly A. Dillen, and Maliha Aziz

Subjects
Multidisciplinary, Livestock associated, lcsh:R, lcsh:Medicine, Biology, Pathogenicity, medicine.disease_cause, Microbiology, Community associated, Staphylococcus aureus, medicine, lcsh:Q, Soft tissue infection, lcsh:Science
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2019
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2. Comparison of livestock-associated and community-associated Staphylococcus aureus pathogenicity in a mouse model of skin and soft tissue infection

Author

David W. Mohr, Carly A. Dillen, Jesper Larsen, Roger V. Ortines, Pranay R. Randad, Lance B. Price, Christopher D. Heaney, Lloyd S. Miller, Karen C. Carroll, Tara C. Smith, Maliha Aziz, and Hülya Kaya

Subjects
Methicillin-Resistant Staphylococcus aureus, 0301 basic medicine, Livestock, lcsh:Medicine, Virulence, Biology, medicine.disease_cause, Virulence factor, Article, Microbiology, Lesion, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Skin Diseases, Infectious, lcsh:Science, Author Correction, Poultry Diseases, Multidisciplinary, Strain (chemistry), Transmission (medicine), Soft Tissue Infections, lcsh:R, Staphylococcal Infections, Pathogenicity, Community-Acquired Infections, Disease Models, Animal, 030104 developmental biology, Staphylococcus aureus, lcsh:Q, Soft tissue infection, medicine.symptom, Bacterial infection, Infection, 030217 neurology & neurosurgery
Abstract

Industrial hog operation (IHO) workers are at increased risk of carrying Staphylococcus aureus in their nares, particularly strains that are livestock-associated (LA) and multidrug-resistant. The pathogenicity of LA-S. aureus strains remains unclear, with some prior studies suggesting reduced transmission and virulence in humans compared to community-associated methicillin-resistant (CA-MRSA) S. aureus. The objective of this study was to determine the degree to which LA-S. aureus strains contracted by IHO workers cause disease relative to a representative CA-MRSA strain in a mouse model of skin and soft tissue infection (SSTI). Mice infected with CC398 LA-S. aureus strains (IHW398-1 and IHW398-2) developed larger lesion sizes with higher bacterial burden than mice infected with CA-MRSA (SF8300) (p S. aureus infected mice had decreased IL-1β protein levels compared with CA-MRSA-infected mice (p S. aureus SSTIs. WGSA revealed heterogeneity in virulence factor and antimicrobial resistance genes carried by LA-S. aureus and CA-MRSA strains. The observed pathogenicity suggest that more attention should be placed on preventing the spread of LA-S. aureus into human populations.

Published
2019

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