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Abstract Methane-air explosion is one of the major disasters in industrial process. The explosion strength could be influenced by the crushed coal gangue, which is widely distributed in coal mine gob and roadway. To understand the influence of the coal gangue on gas explosion, an experimental system with a 0.2 × 0.2 × 3.0 m3 pipeline was designed and explosion experiments of coal gangue with 5 blockage length-diameter ratios (ratio of axial blockage length to pipeline equivalent diameter) were carried out. The results show that coal gangue can cause significant disturbances to the flame front, resulting in a violent acceleration of the explosion flame. The overpressure ratio presents a negative exponential function distribution with the blockage length-diameter ratio. The influence range increases with the blockage length-diameter ratio under the condition of rich fuel, and reaches the maximum when equivalent ratio is 1.237. The explosion intensity is more sensitive to the blockage length-diameter ratio for the equivalent ratio equals 1.0 and 1.237. The formation of high-intensity explosion should be avoided by controlling the accumulation state of the overlying rock in coal mining.

The biological role of interleukin-37 (IL-37) in cancer is large unknown. Through immunohistochemical detection using 163 primary hepatocellular carcinoma (HCC) clinical specimens, we found the expression of IL-37 was decreased in tumor tissues, and the expression level was negatively correlated with tumor size. High expression of IL-37 in HCC tumor tissues was associated with better overall survival (OS) and disease-free survival (DFS). IL-37 expression in tumor tissues was positively associated with the density of tumor-infiltrating CD571natural killer (NK) cells, but not with the CD31and CD81T cells. Consistently, in vitro chemotaxis analysis showed that IL-37- overexpressing HCC cells could recruit more NK cells. The in vivo mouse model experiments also revealed that overexpression IL-37 in HCC cells significantly delayed tumor growth and recruited more NK cells into tumors tissues. Our finding suggested that IL-37 might play an important role for the prognosis of HCC patients via regulating innate immune-action. [ABSTRACT FROM AUTHOR]

Differentiated thyroid cancer (DTC) patients with negative serum thyroglobulin (Tg), negative 131 I whole-body scintigraphy ( 131 I-WBS) at first post-ablation and progressively increased TgAb level are a relatively rare entity in the follow-up after total thyroidectomy and radioactive iodine therapy. The value of 18 F-FDG PET/CT in detecting the recurrence of disease in these patients has only been reported in a small case series. The goal of this study was to investigate the diagnostic accuracy of 18 F-FDG PET/CT in detecting recurrent disease in these specific PTC patients and to identify risk factors for patients with positive 18 F-FDG PET/CT results. Eighty-two PTC patients who had 18 F-FDG PET/CT scans with negative Tg, negative 131 I-WBS at first post-ablation and progressively increased TgAb levels were included. We found that the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18 F-FDG PET/CT in this patient group were determined as 84%, 72%, 92%, 57% and 82%, respectively. 18 F-FDG PET/CT scan had a good diagnostic performance and should be performed routinely in PTC patients with negative Tg, negative 131 I-WBS at first postablation and progressively increased TgAb level, especially when span for progressively increased TgAb level ≥ 3 years and/or progressively increased TgAb value up to 150 IU/mL.