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Your search keyword '"Simeonov, Anton"' showing total 11 results
Start Over Author "Simeonov, Anton" Journal scientific reports
11 results on '"Simeonov, Anton"'

2. Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites

Author

Dorjsuren, Dorjbal, Eastman, Richard T., Wicht, Kathryn J., Jansen, Daniel, Talley, Daniel C., Sigmon, Benjamin A., Zakharov, Alexey V., Roncal, Norma, Girvin, Andrew T., Antonova-Koch, Yevgeniya, Will, Paul M., Shah, Pranav, Sun, Hongmao, Klumpp-Thomas, Carleen, Mok, Sachel, Yeo, Tomas, Meister, Stephan, Marugan, Juan Jose, Ross, Leila S., Xu, Xin, Maloney, David J., Jadhav, Ajit, Mott, Bryan T., Sciotti, Richard J., Winzeler, Elizabeth A., Waters, Norman C., Campbell, Robert F., Huang, Wenwei, Simeonov, Anton, and Fidock, David A.

Published
2021
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8. Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington’s Disease Model through the Application of Quantitative Systems Pharmacology

Author

Pei, Fen, primary, Li, Hongchun, additional, Henderson, Mark J., additional, Titus, Steven A., additional, Jadhav, Ajit, additional, Simeonov, Anton, additional, Cobanoglu, Murat Can, additional, Mousavi, Seyed H., additional, Shun, Tongying, additional, McDermott, Lee, additional, Iyer, Prema, additional, Fioravanti, Michael, additional, Carlisle, Diane, additional, Friedlander, Robert M., additional, Bahar, Ivet, additional, Taylor, D. Lansing, additional, Lezon, Timothy R., additional, Stern, Andrew M., additional, and Schurdak, Mark E., additional

Published
2017
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9. Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays

Author

Urban, Daniel J., primary, Martinez, Natalia J., additional, Davis, Mindy I., additional, Brimacombe, Kyle R., additional, Cheff, Dorian M., additional, Lee, Tobie D., additional, Henderson, Mark J., additional, Titus, Steven A., additional, Pragani, Rajan, additional, Rohde, Jason M., additional, Liu, Li, additional, Fang, Yuhong, additional, Karavadhi, Surendra, additional, Shah, Pranav, additional, Lee, Olivia W., additional, Wang, Amy, additional, McIver, Andrew, additional, Zheng, Hongchao, additional, Wang, Xiaodong, additional, Xu, Xin, additional, Jadhav, Ajit, additional, Simeonov, Anton, additional, Shen, Min, additional, Boxer, Matthew B., additional, and Hall, Matthew D., additional

Published
2017
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10. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

Author

Huang, Ruili, primary, Sakamuru, Srilatha, additional, Martin, Matt T., additional, Reif, David M., additional, Judson, Richard S., additional, Houck, Keith A., additional, Casey, Warren, additional, Hsieh, Jui-Hua, additional, Shockley, Keith R., additional, Ceger, Patricia, additional, Fostel, Jennifer, additional, Witt, Kristine L., additional, Tong, Weida, additional, Rotroff, Daniel M., additional, Zhao, Tongan, additional, Shinn, Paul, additional, Simeonov, Anton, additional, Dix, David J., additional, Austin, Christopher P., additional, Kavlock, Robert J., additional, Tice, Raymond R., additional, and Xia, Menghang, additional

Published
2014
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11. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.

Author

Ruili Huang, Srilatha Sakamuru, Martin, Matt T., Reif, David M., Judson, Richard S., Houck, Keith A., Casey, Warren, Jui-Hua Hsieh, Shockley, Keith R., Ceger, Patricia, Fostel, Jennifer, Witt, Kristine L., Weida Tong, Rotroff, Daniel M., Tongan Zhao, Shinn, Paul, Simeonov, Anton, Dix, David J., Austin, Christopher P., and Kavlock, Robert J.

Subjects
CHEMICAL agonists, CHEMICAL inhibitors, ESTROGEN receptors, REPORTER genes, CELL lines, LIGAND binding (Biochemistry), STRUCTURE-activity relationships
Abstract

The U.S. Tox21 program has screened a library of approximately 10,000 (10K) environmental chemicals and drugs in three independent runs for estrogen receptor alpha (ERa) agonist and antagonist activity using two types of ER reporter gene cell lines, one with an endogenous full length ERα (ER-luc; BG1 cell line) and the other with a transfected partial receptor consisting of the ligand binding domain (ER-bla; ERα β-lactamase cell line), in a quantitative high-throughput screening (qHTS) format. The ability of the two assays to correctly identify ERa agonists and antagonists was evaluated using a set of 39 reference compounds with known ERα activity. Although both assays demonstrated adequate (i.e.>80%) predictivity, the ER-luc assay was more sensitive and the ER-bla assay more specific. The qHTS assay results were compared with results from previously published ERa binding assay data and showed >80% consistency. Actives identified from both the ER-bla and ER-luc assays were analyzed for structure-activity relationships (SARs) revealing known and potentially novel ERa active structure classes. The results demonstrate the feasibility of qHTS to identify environmental chemicals with the potential to interact with the ERa signaling pathway and the two different assay formats improve the confidence in correctly identifying these chemicals. [ABSTRACT FROM AUTHOR]

Published
2014
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