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Your search keyword '"Sonoyama, Takuhiro"' showing total 6 results
Start Over Author "Sonoyama, Takuhiro" Journal scientific reports
6 results on '"Sonoyama, Takuhiro"'

1. Author Correction: Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice

Author

Homma, Tomoyuki, Nagata, Noriyo, Hashimoto, Masayuki, Iwata-Yoshikawa, Naoko, Seki, Naomi M., Shiwa-Sudo, Nozomi, Ainai, Akira, Dohi, Keiji, Nikaido, Eiji, Mukai, Akiko, Ukai, Yuuta, Nakagawa, Takayuki, Shimo, Yusuke, Maeda, Hiroki, Shirai, Seiki, Aoki, Miwa, Sonoyama, Takuhiro, Sato, Mamoru, Fumoto, Masataka, Nagira, Morio, Nakata, Fumihisa, Hashiguchi, Takao, Suzuki, Tadaki, Omoto, Shinya, and Hasegawa, Hideki

Published
2024
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3. Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice

Author

Homma, Tomoyuki, Nagata, Noriyo, Hashimoto, Masayuki, Iwata-Yoshikawa, Naoko, Seki, Naomi M., Shiwa-Sudo, Nozomi, Ainai, Akira, Dohi, Keiji, Nikaido, Eiji, Mukai, Akiko, Ukai, Yuuta, Nakagawa, Takayuki, Shimo, Yusuke, Maeda, Hiroki, Shirai, Seiki, Aoki, Miwa, Sonoyama, Takuhiro, Sato, Mamoru, Fumoto, Masataka, Nagira, Morio, Nakata, Fumihisa, Hashiguchi, Takao, Suzuki, Tadaki, Omoto, Shinya, and Hasegawa, Hideki

Published
2022
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5. Significance of dopamine D1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells

Author

Matsuo, Koji, primary, Sone, Masakatsu, additional, Honda-Kohmo, Kyoko, additional, Toyohara, Takafumi, additional, Sonoyama, Takuhiro, additional, Taura, Daisuke, additional, Kojima, Katsutoshi, additional, Fukuda, Yorihide, additional, Ohno, Youichi, additional, Inoue, Mayumi, additional, Ohta, Akira, additional, Osafune, Kenji, additional, Nakao, Kazuwa, additional, and Inagaki, Nobuya, additional

Published
2017
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6. Significance of dopamine D 1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells.

Author

Matsuo K, Sone M, Honda-Kohmo K, Toyohara T, Sonoyama T, Taura D, Kojima K, Fukuda Y, Ohno Y, Inoue M, Ohta A, Osafune K, Nakao K, and Inagaki N

Subjects
3-Hydroxysteroid Dehydrogenases metabolism, Adrenal Cortex Hormones metabolism, Biomarkers analysis, Cabergoline metabolism, Dopamine Agonists metabolism, Humans, Transcription Factors analysis, Cell Differentiation, Induced Pluripotent Stem Cells drug effects, Induced Pluripotent Stem Cells physiology, Receptors, Dopamine D1 metabolism, Signal Transduction
Abstract

Human induced pluripotent stem cells (hiPSCs) are expected to be both a revolutionary cell source for regenerative medicine and a powerful tool to investigate the molecular mechanisms underlying human cell development in vitro. In the present study, we tried to elucidate the steroidogenic differentiation processes using hiPSC-derived intermediate mesoderm (IM) that is known to be the origin of the human adrenal cortex and gonads. We first performed chemical screening to identify small molecules that induce steroidogenic differentiation of IM cells expressing Odd-skipped related 1 (OSR1), an early IM marker. We identified cabergoline as an inducer of 3β-hydroxysteroid dehydrogenase, an essential enzyme for adrenogonadal steroidogenesis. Although cabergoline is a potent dopamine D 2 receptor agonist, additional experiments showed that cabergoline exerted effects as a low-affinity agonist of D 1 receptors by increasing intracellular cyclic AMP. Further analysis of OSR1 + cells transfected with steroidogenic factor-1/adrenal 4 binding protein revealed that D 1 receptor agonist upregulated expression of various steroidogenic enzymes and increased secretion of steroid hormones synergistically with adrenocorticotropic hormone. These results suggest the importance of dopamine D 1 receptor signalling in steroidogenic differentiation, which contributes to effective induction of steroidogenic cells from hiPSCs.

Published
2017
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