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Your search keyword '"Tarry‐Adkins, Jane L."' showing total 2 results
Start Over Author "Tarry‐Adkins, Jane L." Journal scientific reports
2 results on '"Tarry‐Adkins, Jane L."'

2. Insulin-signalling dysregulation and inflammation is programmed trans-generationally in a female rat model of poor maternal nutrition

Author

Tarry-Adkins, Jane L, Aiken, Catherine E, Ashmore, Thomas J, Ozanne, Susan E, Aiken, Catherine [0000-0002-6510-5626], Ozanne, Susan [0000-0001-8753-5144], and Apollo - University of Cambridge Repository

Subjects
Blood Glucose, Inflammation, lcsh:R, lcsh:Medicine, Maternal Nutritional Physiological Phenomena, Article, Rats, Pregnancy, Models, Animal, Animals, Insulin, lcsh:Q, Female, Inflammation Mediators, Insulin Resistance, Rats, Wistar, lcsh:Science, Muscle, Skeletal, Signal Transduction
Abstract

Developmental programming phenotypes can be recapitulated in subsequent generations not directly exposed to the initial suboptimal intrauterine environment. A maternal low-protein diet during pregnancy and postnatal catch-up growth (‘recuperated’) alters insulin signaling and inflammation in rat offspring (F1-generation). We aimed to establish if this phenotype is also present in F2-generation females. Insulin-receptor-substrate-1 protein expression was decreased in para-ovarian adipose tissue at 3 months in offspring exposed to a grand-maternal low-protein diet (F2-recuperated), vs. F2-control animals (p

Published
2018

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