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7 results on '"Teixeira, Samuel Cota"'

1. Cyclooxygenase (COX)-2 modulates Toxoplasma gondii infection, immune response and lipid droplets formation in human trophoblast cells and villous explants

Author

de Souza, Guilherme, Silva, Rafaela José, Milián, Iliana Claudia Balga, Rosini, Alessandra Monteiro, de Araújo, Thádia Evelyn, Teixeira, Samuel Cota, Oliveira, Mário Cézar, Franco, Priscila Silva, da Silva, Claudio Vieira, Mineo, José Roberto, Silva, Neide Maria, Ferro, Eloisa Amália Vieira, and Barbosa, Bellisa Freitas

Published
2021
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2. A selective CuII complex with 4-fluorophenoxyacetic acid hydrazide and phenanthroline displays DNA-cleaving and pro-apoptotic properties in cancer cells

Author

Machado, Pedro Henrique Alves, Paixão, Drielly Aparecida, Lino, Ricardo Campos, de Souza, Tiago Rodrigues, de Souza Bontempo, Nayara Júnia, Sousa, Luana Munique, Van Petten de Vasconcelos Azevedo, Fernanda, Orsolin, Priscila Capelari, Lima, Paula Marynella Alves Pereira, Martins, Isabella Castro, da Costa Guerra, Joyce Ferreira, Teixeira, Samuel Cota, Araújo, Thaise Gonçalves, Goulart, Luiz Ricardo, Morelli, Sandra, Guerra, Wendell, and de Oliveira Júnior, Robson José

Published
2021
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3. Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy

Author

Teixeira, Samuel Cota, Lopes, Daiana Silva, Gimenes, Sarah Natalie Cirilo, Teixeira, Thaise Lara, da Silva, Marcelo Santos, Brígido, Rebecca Tavares e Silva, da Luz, Felipe Andrés Cordero, da Silva, Aline Alves, Silva, Makswell Almeida, Florentino, Pilar Veras, Tavares, Paula Cristina Brígido, dos Santos, Marlus Alves, Ávila, Veridiana de Melo Rodrigues, Silva, Marcelo José Barbosa, Elias, Maria Carolina, Mortara, Renato Arruda, and da Silva, Claudio Vieira

Published
2017
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4. Copaifera spp. oleoresins impair Toxoplasma gondii infection in both human trophoblastic cells and human placental explants

Author

Teixeira, Samuel Cota, primary, de Souza, Guilherme, additional, Borges, Bruna Cristina, additional, de Araújo, Thádia Evelyn, additional, Rosini, Alessandra Monteiro, additional, Aguila, Fábio Alves, additional, Ambrósio, Sergio Ricardo, additional, Veneziani, Rodrigo Cassio Sola, additional, Bastos, Jairo Kenupp, additional, Silva, Marcelo José Barbosa, additional, Martins, Carlos Henrique Gomes, additional, de Freitas Barbosa, Bellisa, additional, and Ferro, Eloisa Amália Vieira, additional

Published
2020
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5. A selective CuII complex with 4-fluorophenoxyacetic acid hydrazide and phenanthroline displays DNA-cleaving and pro-apoptotic properties in cancer cells.

Author

Machado, Pedro Henrique Alves, Paixão, Drielly Aparecida, Lino, Ricardo Campos, de Souza, Tiago Rodrigues, de Souza Bontempo, Nayara Júnia, Sousa, Luana Munique, Van Petten de Vasconcelos Azevedo, Fernanda, Orsolin, Priscila Capelari, Lima, Paula Marynella Alves Pereira, Martins, Isabella Castro, da Costa Guerra, Joyce Ferreira, Teixeira, Samuel Cota, Araújo, Thaise Gonçalves, Goulart, Luiz Ricardo, Morelli, Sandra, Guerra, Wendell, and de Oliveira Júnior, Robson José

Subjects
CANCER cells, PHENANTHROLINE, CANCER treatment, ACIDS, AUTOPHAGY
Abstract

The thin line between efficacy and toxicity has challenged cancer therapy. As copper is an essential micronutrient and is important to tumor biology, CuII complexes emerged as an alternative to chemotherapy; however, its biological properties need to be better understood. Thus, we report in vitro the antitumor effects of two CuII complexes named [Cu(4-fh)(phen)(ClO4)2] (complex 1) and [Cu(4-nh)(phen)(ClO4)2]·H2O (complex 2), in which 4-fh = 4-fluorophenoxyacetic acid hydrazide; 4-nh = 4-nitrobenzoic hydrazide and phen = 1,10-phenanthroline. Both complexes presented cytotoxic activity against tumor cells, but only complex 1 showed significant selectivity. Complex 1 also induced DNA-damage, led to G0/G1 arrest and triggered apoptosis, which was initiated by an autophagy dysfunction. The significant in vitro selectivity and the action mechanism of complex 1 are noteworthy and reveal this prodrug as promising for anticancer therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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6. Trypanosoma cruzi P21: a potential novel target for chagasic cardiomyopathy therapy

Author

Teixeira, Thaise Lara, primary, Machado, Fabrício Castro, additional, Alves da Silva, Aline, additional, Teixeira, Samuel Cota, additional, Borges, Bruna Cristina, additional, dos Santos, Marlus Alves, additional, Martins, Flávia Alves, additional, Brígido, Paula Cristina, additional, Rodrigues, Adele Aud, additional, Notário, Ana Flávia Oliveira, additional, Ferreira, Bruno Antônio, additional, Servato, João Paulo Silva, additional, Deconte, Simone Ramos, additional, Lopes, Daiana Silva, additional, Ávila, Veridiana Melo Rodrigues, additional, Araújo, Fernanda de Assis, additional, Tomiosso, Tatiana Carla, additional, Silva, Marcelo José Barbosa, additional, and da Silva, Claudio Vieira, additional

Published
2015
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7. Trypanosoma cruzi P21: a potential novel target for chagasic cardiomyopathy therapy.

Author

Machado, Fabrício Castro, Teixeira, Thaise Lara, Alves da Silva, Aline, Teixeira, Samuel Cota, Borges, Bruna Cristina, dos Santos, Marlus Alves, Martins, Flávia Alves, Brígido, Paula Cristina, Rodrigues, Adele Aud, Notário, Ana Flávia Oliveira, Ferreira, Bruno Antônio, Servato, João Paulo Silva, Deconte, Simone Ramos, Araújo, Fernanda de Assis, Tomiosso, Tatiana Carla, Silva, Marcelo José Barbosa, da Silva, Claudio Vieira, Lopes, Daiana Silva, and Ávila, Veridiana Melo Rodrigues

Subjects
TRYPANOSOMA cruzi, CHAGAS' disease, CARDIOMYOPATHIES, AUTOIMMUNITY
Abstract

Chagas disease, which is caused by the parasite Trypanosoma cruzi, is an important cause of cardiomyopathy in Latin America. It is estimated that 10%-30% of all infected individuals will acquire chronic chagasic cardiomyopathy (CCC). The etiology of CCC is multifactorial and involves parasite genotype, host genetic polymorphisms, immune response, signaling pathways and autoimmune progression. Herein we verified the impact of the recombinant form of P21 (rP21), a secreted T. cruzi protein involved in host cell invasion, on progression of inflammatory process in a polyester sponge-induced inflammation model. Results indicated that rP21 can recruit immune cells induce myeloperoxidase and IL-4 production and decrease blood vessels formation compared to controls in vitro and in vivo. In conclusion, T. cruzi P21 may be a potential target for the development of P21 antagonist compounds to treat chagasic cardiomyopathy. [ABSTRACT FROM AUTHOR]

Published
2015
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