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11 results on '"Tian, Geng"'

4. Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A

Author

Prakash, Rucktooa, Robert K Y, Cheng, Elena, Segala, Tian, Geng, James C, Errey, Giles A, Brown, Robert M, Cooke, Fiona H, Marshall, and Andrew S, Doré

Subjects
Models, Molecular, Receptor, Adenosine A2A, Molecular Conformation, Humans, Crystallography, X-Ray, Ligands, Article, Protein Unfolding, Receptors, G-Protein-Coupled
Abstract

Here we report an efficient method to generate multiple co-structures of the A2A G protein-coupled receptor (GPCR) with small-molecules from a single preparation of a thermostabilised receptor crystallised in Lipidic Cubic Phase (LCP). Receptor crystallisation is achieved following purification using a low affinity “carrier” ligand (theophylline) and crystals are then soaked in solutions containing the desired (higher affinity) compounds. Complete datasets to high resolution can then be collected from single crystals and seven structures are reported here of which three are novel. The method significantly improves structural throughput for ligand screening using stabilised GPCRs, thereby actively driving Structure-Based Drug Discovery (SBDD).

Published
2017

5. Statistical analysis of mutant allele frequency level of circulating cell-free DNA and blood cells in healthy individuals

Author

Xia, Ligang, primary, Li, Zhoufang, additional, Zhou, Bo, additional, Tian, Geng, additional, Zeng, Lidong, additional, Dai, Hongyu, additional, Li, Xiaohua, additional, Liu, Chaoyu, additional, Lu, Shixin, additional, Xu, Feiyue, additional, Tu, Xiaonian, additional, Deng, Fang, additional, Xie, Yuancai, additional, Huang, Weiren, additional, and He, Jiankui, additional

Published
2017
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6. VEGF-B inhibits hyperglycemia- and Macugen-induced retinal apoptosis

Author

Huang, Delong, primary, Zhao, Chen, additional, Ju, Rong, additional, Kumar, Anil, additional, Tian, Geng, additional, Huang, Lijuan, additional, Zheng, Lei, additional, Li, Xianglin, additional, Liu, Lixian, additional, Wang, Shasha, additional, Ren, Xiangrong, additional, Ye, Zhimin, additional, Chen, Wei, additional, Xing, Liying, additional, Chen, Qishan, additional, Gao, Zhiqin, additional, Mi, Jia, additional, Tang, Zhongshu, additional, Wang, Bin, additional, Zhang, Shuping, additional, Lee, Chunsik, additional, and Li, Xuri, additional

Published
2016
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