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Start Over Author "Wang XiaoMei" Journal scientific reports
23 results on '"Wang XiaoMei"'

3. Quantifying perinatal transmission of Hepatitis B viral quasispecies by tag linkage deep sequencing

Author

Du, Yushen, Chi, Xiumei, Wang, Chong, Jiang, Jing, Kong, Fei, Yan, Hongqing, Wang, Xiaomei, Li, Jie, Wu, Nicholas C, Dai, Lei, Zhang, Tian-Hao, Shu, Sara, Zhou, Jian, Yoshizawa, Janice M, Li, Xinmin, Bhattacharya, Debika, Wu, Ting-ting, Niu, Junqi, and Sun, Ren

Subjects
Biomedical and Clinical Sciences, Immunology, HIV/AIDS, Digestive Diseases, Genetics, Liver Disease, Infectious Diseases, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Hepatitis, Hepatitis - B, Chronic Liver Disease and Cirrhosis, Infection, Good Health and Well Being, Child, DNA, Viral, Evolution, Molecular, Female, Haplotypes, Hepatitis B, Hepatitis B virus, High-Throughput Nucleotide Sequencing, Humans, Infectious Disease Transmission, Vertical, Phylogeny, Pregnancy, Pregnancy Complications, Infectious, Quasispecies, Sequence Analysis, DNA
Abstract

Despite full immunoprophylaxis, mother-to-child transmission (MTCT) of Hepatitis B Virus still occurs in approximately 2-5% of HBsAg positive mothers. Little is known about the bottleneck of HBV transmission and the evolution of viral quasispecies in the context of MTCT. Here we adopted a newly developed tag linkage deep sequencing method and analyzed the quasispecies of four MTCT pairs that broke through immunoprophylaxis. By assigning unique tags to individual viral sequences, we accurately reconstructed HBV haplotypes in a region of 836 bp, which contains the major immune epitopes and drug resistance mutations. The detection limit of minor viral haplotypes reached 0.1% for individual patient sample. Dominance of "a determinant" polymorphisms were observed in two children, which pre-existed as minor quasispecies in maternal samples. In all four pairs of MTCT samples, we consistently observed a significant overlap of viral haplotypes shared between mother and child. We also demonstrate that the data can be potentially useful to estimate the bottleneck effect during HBV MTCT, which provides information to optimize treatment for reducing the frequency of MTCT.

Published
2017

6. High prevalence of Clonorchis sinensis infections and coinfection with hepatitis virus in riverside villages in northeast China

Author

Gao, Yanhang, Li, Yanqing, Liu, Xiaowen, Zhang, Tong, Yu, Ge, Wang, Yang, Shi, Ying, Chi, Xiumei, Wang, Xiaomei, Gao, Xiuzhu, Wu, Ruihong, Zhang, Yingyu, Hang, Lei, Sun, Shijuan, Guan, Yazhe, Xu, Ying, Meng, Jing, Liu, Xu, Jiang, Chang, Ma, Heming, Luo, Liting, Yan, Qi, Yin, Xin, Peng, Fei, Zhi, Yixiao, Qu, Weige, Zhang, Xia, Ren, Tianqi, Liu, Lili, Zhao, Jinming, Zhang, Feiyu, Yakepu, Adila, Pan, Yu, Xu, Hongqin, and Niu, Junqi

Published
2020
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9. Antithrombotic effects and related mechanisms of Salvia deserta Schang root EtOAc extracts

Author

Yuming Mu, Xinling Wang, Junping Hu, Wang Xiaomei, Rena Kasimu, and Wang Xiaoqing

Subjects
Blood Platelets, Male, Platelet Aggregation, lcsh:Medicine, Panax notoginseng, Salvia miltiorrhiza, 030204 cardiovascular system & hematology, Pharmacology, Plant Roots, Article, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Fibrinolytic Agents, Von Willebrand factor, von Willebrand Factor, Antithrombotic, medicine, Animals, Carotid Artery Thrombosis, lcsh:Science, Blood Coagulation, Camphanes, Multidisciplinary, biology, Chemistry, lcsh:R, Anticoagulants, Thrombosis, Salvia deserta, biology.organism_classification, Rats, Thromboxane B2, Coagulation, Tissue Plasminogen Activator, 030220 oncology & carcinogenesis, biology.protein, lcsh:Q, Female, Rabbits, Plasminogen activator, Protein C, Drugs, Chinese Herbal, medicine.drug
Abstract

Salvia deserta Schang (SDS) belongs to the same family as Salvia miltiorrhiza bunge, one of the antithrombotic Chinese herbal medicines. In our study, EtOAc root extracts were analyzed for their effects on adenosine diphosphate (ADP)-induced platelet aggregation in rabbits and FeCl3-induced rat common carotid artery thrombosis as well as on rat blood plasma concentrations of thromboxane B2 (TXB2), 6-keto-prostaglandin F1 alpha (6-keto-PGF1α), antithrombin-III (AT-III), protein C (PC), plasminogen (PLG), plasminogen activator inhibitor (PAI-1), von Willebrand factor (vWF) and tissue-type plasminogen activator (t-PA). EtOAc extracts from SDS roots had significant inhibitory effects on ADP-induced maximum platelet aggregation rate (10.2 ± 2.6 vs control 35.7 ± 5.2; P 3-induced rat common carotid artery thrombus weight and thrombus area ratio (P 2, vWF and PAI-1 levels and increased 6-keto-PGF1α and t-PA levels in a dose dependent manner (all P 2/6-keto-PGF1α was significantly decreased (P PAI-1 was significantly increased (P

Published
2018

11. Non-alcoholic fatty liver disease incidence, remission and risk factors among a general Chinese population with a 6-year follow-up

Author

Wu, Jing, primary, He, Shumei, additional, Xu, Hongqin, additional, Chi, Xiumei, additional, Sun, Jie, additional, Wang, Xiaomei, additional, Gao, Xiuzhu, additional, Wu, Ruihong, additional, Shao, Mingbai, additional, Zhao, Heng, additional, Jia, Jing, additional, Wang, Chunyan, additional, and Niu, Junqi, additional

Published
2018
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13. Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells

Author

Dong, Chao, primary, Yang, Runxiang, additional, Li, Hongjian, additional, Ke, Kunbin, additional, Luo, Chunxiang, additional, Yang, Fang, additional, Shi, Xi-Nan, additional, Zhu, Ying, additional, Liu, Xu, additional, Wong, Man-Hon, additional, Lin, Guimiao, additional, Wang, Xiaomei, additional, Leung, Kwong-Sak, additional, Kung, Hsiang-Fu, additional, Chen, Ceshi, additional, and Lin, Marie Chia-mi, additional

Published
2017
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16. Novel characteristics of the avian gyrovirus 2 genome

Author

Yao, Shuai, primary, Gao, Xiang, additional, Tuo, Tianbei, additional, Han, Chunyan, additional, Gao, Yulong, additional, Qi, Xiaole, additional, Zhang, Yanping, additional, Liu, Changjun, additional, Gao, Honglei, additional, Wang, Yongqiang, additional, and Wang, Xiaomei, additional

Published
2017
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18. The Reproductive Toxicity of CdSe/ZnS Quantum Dots on the in vivo Ovarian Function and in vitro Fertilization

Author

Xu, Gaixia, primary, Lin, Guimiao, additional, Lin, Suxia, additional, Wu, Na, additional, Deng, Yueyue, additional, Feng, Gang, additional, Chen, Qiang, additional, Qu, Junle, additional, Chen, Danni, additional, Chen, Siping, additional, Niu, Hanben, additional, Mei, Shujiang, additional, Yong, Ken-Tye, additional, and Wang, Xiaomei, additional

Published
2016
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22. Trypsin- and low pH-mediated fusogenicity of avian metapneumovirus fusion proteins is determined by residues at positions 100, 101 and 294

Author

Yun, Bingling, primary, Guan, Xiaolu, additional, Liu, Yongzhen, additional, Gao, Yanni, additional, Wang, Yongqiang, additional, Qi, Xiaole, additional, Cui, Hongyu, additional, Liu, Changjun, additional, Zhang, Yanping, additional, Gao, Li, additional, Li, Kai, additional, Gao, Honglei, additional, Gao, Yulong, additional, and Wang, Xiaomei, additional

Published
2015
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