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4 results on '"Wenchao Hu"'

1. Association of serum and aqueous humor myonectin concentrations with diabetic retinopathy

Author

Huibo Sun, Zhongtao Li, Wenchao Hu, and Wenjie Ma

Subjects
Medicine, Science
Abstract

Abstract Myonectin, a newly discovered myokine, enhances fatty acid uptake in cultured adipocytes and hepatocytes and suppresses circulating levels of free fatty acids in mice. This study is performed to evaluate the association between serum and aqueous humor myonectin concentrations with diabetic retinopathy (DR). This study was performed in a population of 228 patients with type 2 diabetes (T2DM) and 72 control subjects. Diabetic patients were then divided into T2DM patients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients. Serum and aqueous humor myonectin concentrations were significantly lower in the case group than in the control group. PDR patients showed significantly decreased serum and aqueous humor myonectin concentrations than in the other two T2DM patients. In addition, NPDR patients showed significantly lower serum and aqueous humor myonectin concentrations than T2DM patients without DR. Logistic regression analysis demonstrated that serum and aqueous humor myonectin was correlated with a decreased risk of T2DM and DR. Simple linear regression analysis showed that serum myonectin was negatively correlated with duration of disease, body mass index (BMI), and HbA1c. Duration of disease and BMI were still correlated with the serum myonectin after a multiple linear regression analysis. Aqueous humor myonectin was negatively correlated with duration of disease, systolic blood pressure (SBP), and diastolic blood pressure. Duration of disease and SBP was still correlated with the aqueous humor myonectin after a multiple linear regression analysis. Our investigation indicates an inverse association of serum and aqueous humor myonectin with DR.

Published
2021
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2. All-Optical Implementation of the Ant Colony Optimization Algorithm

Author

Wenchao Hu, Nikolay I. Zheludev, Cesare Soci, Perry Ping Shum, and Kan Wu

Subjects
Optimization problem, Optical Phenomena, Computer science, Computer Science::Neural and Evolutionary Computation, 02 engineering and technology, Models, Biological, 01 natural sciences, Article, Pheromones, 010309 optics, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Animals, Computer Simulation, Optical Fibers, Multidisciplinary, Behavior, Animal, Ants, Ant colony optimization algorithms, 020206 networking & telecommunications, Feeding Behavior, Ant colony, Telecommunications network, Animal Communication, Nonlinear system, Sex pheromone, Graph (abstract data type), Algorithm, Algorithms
Abstract

We report all-optical implementation of the optimization algorithm for the famous “ant colony” problem. Ant colonies progressively optimize pathway to food discovered by one of the ants through identifying the discovered route with volatile chemicals (pheromones) secreted on the way back from the food deposit. Mathematically this is an important example of graph optimization problem with dynamically changing parameters. Using an optical network with nonlinear waveguides to represent the graph and a feedback loop, we experimentally show that photons traveling through the network behave like ants that dynamically modify the environment to find the shortest pathway to any chosen point in the graph. This proof-of-principle demonstration illustrates how transient nonlinearity in the optical system can be exploited to tackle complex optimization problems directly, on the hardware level, which may be used for self-routing of optical signals in transparent communication networks and energy flow in photonic systems.

Published
2016

3. Cold-induced RNA-binding proteins regulate circadian gene expression by controlling alternative polyadenylation

Author

Jing-wen Yin, Yasuhiro Murakawa, Wenchao Hu, Jun Yan, Gang Wang, Markus Landthaler, and Yuting Liu

Subjects
Multidisciplinary, Polyadenylation, Three prime untranslated region, RNA-Binding Proteins, RNA-binding protein, Biology, CIRBP, Molecular biology, Article, Cell Line, Circadian Rhythm, Cold Temperature, Mice, Gene Expression Regulation, Cardiovascular and Metabolic Diseases, Gene expression, Animals, Humans, Circadian rhythm, Binding site, Poly A, Gene, 3' Untranslated Regions
Abstract

The body temperature is considered a universal cue by which the master clock synchronizes the peripheral clocks in mammals, but the mechanism is not fully understood. Here we identified two cold-induced RNA-binding proteins (RBPs), Cirbp and Rbm3, as important regulators for the temperature entrained circadian gene expression. The depletion of Cirbp or Rbm3 significantly reduced the amplitudes of core circadian genes. PAR-CLIP analyses showed that the 3'UTR binding sites of Cirbp and Rbm3 were significantly enriched near the polyadenylation sites (PASs). Furthermore, the depletion of Cirbp or Rbm3 shortened 3'UTR, whereas low temperature (upregulating Cirbp and Rbm3) lengthened 3'UTR. Remarkably, we found that they repressed the usage of proximal PASs by binding to the common 3'UTR, and many cases of proximal/distal PAS selection regulated by them showed strong circadian oscillations. Our results suggested that Cirbp and Rbm3 regulated the circadian gene expression by controlling alternative polyadenylation (APA).

Published
2013

4. Cold-induced RNA-binding proteins regulate circadian gene expression by controlling alternative polyadenylation.

Author

Yuting Liu, Wenchao Hu, Murakawa, Yasuhiro, Jingwen Yin, Gang Wang, Landthaler, Markus, and Jun Yan

Subjects
*CARRIER proteins, *GENE expression, *RNA, *BINDING sites, *CIRCADIAN rhythms
Abstract

The body temperature is considered a universal cue by which the master clock synchronizes the peripheral clocks in mammals, but the mechanism is not fully understood. Here we identified two cold-induced RNA-binding proteins (RBPs), Cirbp and Rbm3, as important regulators for the temperature entrained circadian gene expression. The depletion of Cirbp or Rbm3 significantly reduced the amplitudes of core circadian genes. PAR-CLIP analyses showed that the 39UTR binding sites of Cirbp and Rbm3 were significantly enriched near the polyadenylation sites (PASs). Furthermore, the depletion of Cirbp or Rbm3 shortened 3'UTR, whereas low temperature (upregulating Cirbp and Rbm3) lengthened 3'UTR. Remarkably, we found that they repressed the usage of proximal PASs by binding to the common 39UTR, and many cases of proximal/distal PAS selection regulated by them showed strong circadian oscillations. Our results suggested that Cirbp and Rbm3 regulated the circadian gene expression by controlling alternative polyadenylation (APA). [ABSTRACT FROM AUTHOR]

Published
2013
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