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Start Over Author "Xu, Xiaohui" Journal scientific reports
9 results on '"Xu, Xiaohui"'

6. Corrigendum: RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking

Author

Lin, Xiaosi, Yang, Ting, Wang, Shicong, Wang, Zhen, Yun, Ye, Sun, Lixiang, Zhou, Yunhe, Xu, Xiaohui, Akazawa, Chihiro, Hong, Wanjin, and Wang, Tuanlao

Subjects
ErbB Receptors, Protein Transport, Epidermal Growth Factor, Cell Line, Tumor, MCF-7 Cells, Vesicular Transport Proteins, Humans, Nuclear Proteins, Transport Vesicles, Corrigenda, Adaptor Proteins, Signal Transducing, HeLa Cells
Abstract

The HOPS complex serves as a tethering complex with GEF activity for Ypt7p in yeast to regulate late endosomal membrane maturation. While the role of HOPS complex is well established in yeast cells, its functional and mechanistic aspects in mammalian cells are less well defined. In this study, we report that RILP, a downstream effector of Rab7, interacts with HOPS complex and recruits HOPS subunits to the late endosomal compartment. Structurally, the amino-terminal portion of RILP interacts with HOPS complex. Unexpectedly, this interaction is independent of Rab7. VPS41 subunit of HOPS complex was defined to be the major partner for interacting with RILP. The carboxyl-terminal region of VPS41 was mapped to be responsible for the interaction. Functionally, either depletion of VPS41 by shRNA or overexpression of VPS41 C-terminal half retarded EGF-induced degradation of EGFR. These results suggest that interaction of RILP with HOPS complex via VPS41 plays a role in endocytic trafficking of EGFR.

Published
2015

7. Ndk, a novel host-responsive regulator, negatively regulates bacterial virulence through quorum sensing in Pseudomonas aeruginosa

Author

Yu, Hua, primary, Xiong, Junzhi, additional, Zhang, Rong, additional, Hu, Xiaomei, additional, Qiu, Jing, additional, Zhang, Di, additional, Xu, Xiaohui, additional, Xin, Rong, additional, He, Xiaomei, additional, Xie, Wei, additional, Sheng, Halei, additional, Chen, Qian, additional, Zhang, Le, additional, Rao, Xiancai, additional, and Zhang, Kebin, additional

Published
2016
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