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Your search keyword '"Yasuhiko Hattori"' showing total 2 results
Start Over Author "Yasuhiko Hattori" Journal scientific reports
2 results on '"Yasuhiko Hattori"'

1. PIK3R1Met326Ile germline mutation correlates with cysteine-rich protein 61 expression and poor prognosis in glioblastoma

Author

Yoshihiro Otani, Joji Ishida, Kazuhiko Kurozumi, Tetsuo Oka, Toshihiko Shimizu, Yusuke Tomita, Yasuhiko Hattori, Atsuhito Uneda, Yuji Matsumoto, Hiroyuki Michiue, Shuta Tomida, Takehiro Matsubara, Tomotsugu Ichikawa, and Isao Date

Subjects
Medicine, Science
Abstract

Abstract Despite therapeutic advances, glioblastoma represents a lethal brain tumor. Recently, research to identify prognostic markers for glioblastoma has intensified. Our previous study demonstrated that median progression-free survival (PFS) and overall survival (OS) of patients with high cysteine-rich protein 61 (CCN1) expression was significantly shorter than that of patients with low CCN1 expression. To understand the molecular mechanisms that regulate CCN1 expression, we examined 147 tumour samples from 80 patients with glioblastoma and 67 patients with lower grade glioma. Next-generation and Sanger sequencing showed that PIK3R1Met326Ile was more frequent in the CCN1 high expression group (10/37 cases, 27.0%) than the CCN1 low expression group (3/38 cases, 7.9%) in glioblastoma. This mutation was also detected in corresponding blood samples. In multivariate analysis, high CCN1 expression and PIK3R1Met326Ile in glioblastoma patients were prognostic factors for OS [HR = 2.488 (1.298–4.769), p = 0.006] and [HR = 2.089 (1.020–4.277), p = 0.0439], respectively. Thus, the PIK3R1Met326Ile germline appears to be correlated with CCN1 expression and poor prognosis in glioblastoma.

Published
2017
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2. PIK3R1Met326Ile germline mutation correlates with cysteine-rich protein 61 expression and poor prognosis in glioblastoma

Author

Atsuhito Uneda, Tomotsugu Ichikawa, Yasuhiko Hattori, Isao Date, Toshihiko Shimizu, Yoshihiro Otani, Joji Ishida, Yuji Matsumoto, Tetsuo Oka, Yusuke Tomita, Kazuhiko Kurozumi, Shuta Tomida, Hiroyuki Michiue, and Takehiro Matsubara

Subjects
Adult, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Science, Brain tumor, Biology, Article, Germline, Phosphatidylinositol 3-Kinases, Young Adult, 03 medical and health sciences, symbols.namesake, Germline mutation, Glioma, medicine, Humans, Progression-free survival, Germ-Line Mutation, Survival analysis, Aged, Neoplasm Staging, Aged, 80 and over, Regulation of gene expression, Sanger sequencing, Multidisciplinary, Brain Neoplasms, Gene Expression Profiling, High-Throughput Nucleotide Sequencing, Sequence Analysis, DNA, Middle Aged, Prognosis, medicine.disease, Survival Analysis, Progression-Free Survival, Up-Regulation, Class Ia Phosphatidylinositol 3-Kinase, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Amino Acid Substitution, Cancer research, symbols, Medicine, Female, Glioblastoma, Cysteine-Rich Protein 61
Abstract

Despite therapeutic advances, glioblastoma represents a lethal brain tumor. Recently, research to identify prognostic markers for glioblastoma has intensified. Our previous study demonstrated that median progression-free survival (PFS) and overall survival (OS) of patients with high cysteine-rich protein 61 (CCN1) expression was significantly shorter than that of patients with low CCN1 expression. To understand the molecular mechanisms that regulate CCN1 expression, we examined 147 tumour samples from 80 patients with glioblastoma and 67 patients with lower grade glioma. Next-generation and Sanger sequencing showed that PIK3R1Met326Ile was more frequent in the CCN1 high expression group (10/37 cases, 27.0%) than the CCN1 low expression group (3/38 cases, 7.9%) in glioblastoma. This mutation was also detected in corresponding blood samples. In multivariate analysis, high CCN1 expression and PIK3R1Met326Ile in glioblastoma patients were prognostic factors for OS [HR = 2.488 (1.298–4.769), p = 0.006] and [HR = 2.089 (1.020–4.277), p = 0.0439], respectively. Thus, the PIK3R1Met326Ile germline appears to be correlated with CCN1 expression and poor prognosis in glioblastoma.

Published
2017
Full Text
View/download PDF

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