13 results on '"Yuan Deng"'
Search Results
2. Necrolytic migratory erythema is an important visual cutaneous clue of glucagonoma
- Author
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Wei Li, Xue Yang, Yuan Deng, Yina Jiang, Guiping Xu, Enxiao Li, Yinying Wu, Juan Ren, Zhenhua Ma, Shunbin Dong, Liang Han, Qingyong Ma, Zheng Wu, and Zheng Wang
- Subjects
Medicine ,Science - Abstract
Abstract Glucagonoma is an extremely rare neuroendocrine tumor that arises from pancreatic islet alpha cells. Although glucagonoma is usually accompanied by a variety of characteristic clinical symptoms, early diagnosis is still difficult due to the scarcity of the disease. In this study, we present the cumulative experiences, clinical characteristics and treatments of seven patients diagnosed with glucagonoma during the past 10 years at the First Affiliated Hospital of Xi’an Jiaotong University. The seven patients in our cohort consisted of six females and one male with an average diagnosis age of 40.1 years (range 23–51). The average time from onset of symptoms to diagnosis of glucagonoma was 14 months (range 2–36 months). All the patients visited dermatology first for necrolytic migratory erythema (NME) 7/7 (100%), and other presenting symptoms included diabetes mellitus (DM) 4/7 (57%), stomatitis 2/7 (28%), weight loss 4/7 (57%), anemia 4/7 (57%), diarrhea 1/7 (14%), and DVT1/7 (14%). Plasma glucagon levels were increased in all patients (range 216.92–3155 pg/mL) and declined after surgery. Imaging studies revealed that four of seven patients had liver metastasis. Six of seven patients received surgical resection, and all of them received somatostatin analog therapy. Symptoms improved significantly in 6 out of 7 patients. Three of seven patients died of this disease by the time of follow-up. Our data suggest that if persistent NME is associated with DM and high glucagon levels, timely abdominal imaging should be performed to confirm glucagonoma. Once diagnosed, surgery and somatostatin analogs are effective for symptom relief and tumor control.
- Published
- 2022
- Full Text
- View/download PDF
3. 3D printed scaffolds of calcium silicate-doped β-TCP synergize with co-cultured endothelial and stromal cells to promote vascularization and bone formation
- Author
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Yuan Deng, Chuan Jiang, Cuidi Li, Tao Li, Mingzheng Peng, Jinwu Wang, and Kerong Dai
- Subjects
Medicine ,Science - Abstract
Abstract Synthetic bone scaffolds have potential application in repairing large bone defects, however, inefficient vascularization after implantation remains the major issue of graft failure. Herein, porous β-tricalcium phosphate (β-TCP) scaffolds with calcium silicate (CS) were 3D printed, and pre-seeded with co-cultured human umbilical cord vein endothelial cells (HUVECs) and human bone marrow stromal cells (hBMSCs) to construct tissue engineering scaffolds with accelerated vascularization and better bone formation. Results showed that in vitro β-TCP scaffolds doped with 5% CS (5%CS/β-TCP) were biocompatible, and stimulated angiogenesis and osteogenesis. The results also showed that 5%CS/β-TCP scaffolds not only stimulated co-cultured cells angiogenesis on Matrigel, but also stimulated co-cultured cells to form microcapillary-like structures on scaffolds, and promoted migration of BMSCs by stimulating co-cultured cells to secrete PDGF-BB and CXCL12 into the surrounding environment. Moreover, 5%CS/β-TCP scaffolds enhanced vascularization and osteoinduction in comparison with β-TCP, and synergized with co-cultured cells to further increase early vessel formation, which was accompanied by earlier and better ectopic bone formation when implanted subcutaneously in nude mice. Thus, our findings suggest that porous 5%CS/β-TCP scaffolds seeded with co-cultured cells provide new strategy for accelerating tissue engineering scaffolds vascularization and osteogenesis, and show potential as treatment for large bone defects.
- Published
- 2017
- Full Text
- View/download PDF
4. Population genetic structure of Pomacea canaliculata in China based on the COI and ITS1 genes
- Author
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Wei, Ran, Chang, Ya-Wen, Xie, Hong-Fang, Wu, Cheng-dong, Yuan, Deng-Rong, Gong, Wei-Rong, and Du, Yu-Zhou
- Published
- 2024
- Full Text
- View/download PDF
5. Approaching high-performance of ordered structure Sb2Te3 film via unique angular intraplanar grain boundaries
- Author
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Dali Yan, Yuan Deng, Xiaobiao Liu, Cong Li, Tie Yang, Hui Li, Liyu Hao, and Ming Tan
- Subjects
Multidisciplinary ,Materials science ,Nanoscale materials ,Condensed matter physics ,Structural properties ,lcsh:R ,lcsh:Medicine ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Article ,0104 chemical sciences ,Thermal conductivity ,Electric field ,Thermoelectric effect ,Figure of merit ,Deposition (phase transition) ,lcsh:Q ,Grain boundary ,lcsh:Science ,0210 nano-technology - Abstract
In this paper, we present an innovative electric-field-assisted magnetron-sputtering deposition method for films preparation. By grain boundary-engineering, we successeful obtained the ordered Sb2Te3 film with greatly high figure of merit via controlling external electric field. It has been found that the electric field can induce the change in the angle of intraplanar grain boundaries between (0 1 5) and (0 1 5) planes, which leads to the enhanced holes mobility and maintained low thermal conductivity. The energy filtering takes place at the angular intraplanar grain boundaries. At room temperature, a high ZT value of 1.75 can be achieved in the deposited Sb2Te3 film under 30 V external electric field. This is a very promising approach that the electric field induced deposition can develop high-performance Sb2Te3-based thermoelectric films.
- Published
- 2020
6. Tilt-structure and high-performance of hierarchical Bi1.5Sb0.5Te3 nanopillar arrays
- Author
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Dali Yan, Yuan Deng, Wu Zehua, Ming Tan, and Yanming Hao
- Subjects
Multidisciplinary ,Materials science ,business.industry ,Phonon ,lcsh:R ,Nanowire ,lcsh:Medicine ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Article ,0104 chemical sciences ,Condensed Matter::Materials Science ,Tilt (optics) ,Thermoelectric effect ,Optoelectronics ,Grain boundary ,lcsh:Q ,0210 nano-technology ,business ,lcsh:Science ,Nanopillar - Abstract
The uniquely tilted nanopillar array favorably influence carrier and phonon transport properties. We present an innovative interfacial design concept and a novel tilt-structure of hierarchical Bi1.5Sb0.5Te3 nanopillar array comprising unique interfaces from nano-scaled open gaps to coherent grain boundaries, and tilted nanopillars assembled by high-quality nanowires with well oriented growth, utilizing a simple vacuum thermal evaporation technique. The unusual structure Bi1.5Sb0.5Te3 nanopillar array with a tilt angle of 45° exhibits a high thermoelectric performance ZT = 1.61 at room temperature. The relatively high ZT value in contrast to that of previously reported Bi1.5Sb0.5Te3 materials and the Bi1.5Sb0.5Te3 nanopillar array with a tilt angle of 60° or 90° evidently reveals the crucial role of the unique interface and tilt-structure in favorably influencing carrier and phonon transport properties, resulting in a significantly improved ZT value. This method opens a new approach to optimize nano-structure film materials.
- Published
- 2018
7. Thin-film metallic glass: an effective diffusion barrier for Se-doped AgSbTe2 thermoelectric modules
- Author
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Matthias T. Agne, Jinn P. Chu, G. Jeffrey Snyder, Hsin-Jay Wu, Chia-Chi Yu, and Ping Yuan Deng
- Subjects
010302 applied physics ,Multidisciplinary ,Materials science ,Amorphous metal ,Diffusion barrier ,Diffusion ,Intermetallic ,02 engineering and technology ,Substrate (electronics) ,021001 nanoscience & nanotechnology ,01 natural sciences ,Atomic diffusion ,0103 physical sciences ,Thermoelectric effect ,Thin film ,Composite material ,0210 nano-technology - Abstract
The thermal stability of joints in thermoelectric (TE) modules, which are degraded during interdiffusion between the TE material and the contacting metal, needs to be addressed in order to utilize TE technology for competitive, sustainable energy applications. Herein, we deposit a 200 nm-thick Zr-based thin-film metallic glass (TFMG), which acts as an effective diffusion barrier layer with low electrical contact resistivity, on a high-zT Se-doped AgSbTe2 substrate. The reaction couples structured with TFMG/TE are annealed at 673 K for 8–360 hours and analyzed by electron microscopy. No observable IMCs (intermetallic compounds) are formed at the TFMG/TE interface, suggesting the effective inhibition of atomic diffusion that may be attributed to the grain-boundary-free structure of TFMG. The minor amount of Se acts as a tracer species, and a homogeneous Se-rich region is found nearing the TFMG/TE interface, which guarantees satisfactory bonding at the joint. The diffusion of Se, which has the smallest atomic volume of all the elements from the TE substrate, is found to follow Fick’s second law. The calculated diffusivity (D) of Se in TFMG falls in the range of D~10−20–10−23(m2/s), which is 106~107 and 1012~1013 times smaller than those of Ni [10−14–10−17(m2/s)] and Cu [10−8–10−11(m2/s)] in Bi2Te3, respectively.
- Published
- 2017
8. RhBMP-2 loaded 3D-printed mesoporous silica/calcium phosphate cement porous scaffolds with enhanced vascularization and osteogenesis properties
- Author
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Tao Li, Chuan Jiang, Jinwu Wang, Yuan Deng, Mingzheng Peng, Cuidi Li, and Ning Li
- Subjects
Calcium Phosphates ,0301 basic medicine ,Scaffold ,Bone Regeneration ,Stromal cell ,Bone Morphogenetic Protein 2 ,02 engineering and technology ,Bone healing ,Article ,03 medical and health sciences ,Osteogenesis ,Transforming Growth Factor beta ,In vivo ,Animals ,Humans ,Femur ,Bone regeneration ,Vascular tissue ,Multidisciplinary ,Tissue Scaffolds ,Chemistry ,Silicates ,Regeneration (biology) ,Bone Cements ,Cell Differentiation ,Calcium Compounds ,Mesoporous silica ,Silicon Dioxide ,021001 nanoscience & nanotechnology ,Recombinant Proteins ,030104 developmental biology ,Printing, Three-Dimensional ,Rabbits ,0210 nano-technology ,Biomedical engineering - Abstract
A major limitation in the development of effective scaffolds for bone regeneration has been the limited vascularization of the regenerating tissue. Here, we propose the development of a novel calcium phosphate cement (CPC)-based scaffold combining the properties of mesoporous silica (MS) with recombinant human bone morphogenic protein-2 (rhBMP-2) to facilitate vascularization and osteogenesis. Specifically, the development of a custom MS/CPC paste allowed the three-dimensional (3D) printing of scaffolds with a defined macroporous structure and optimized silicon (Si) ions release profile to promote the ingrowth of vascular tissue at an early stage after implantation in support of tissue viability and osteogenesis. In addition, the scaffold microstructure allowed the prolonged release of rhBMP-2, which in turn significantly stimulated the osteogenesis of human bone marrow stromal cells in vitro and of bone regeneration in vivo as shown in a rabbit femur defect repair model. Thus, the combination MS/CPC/rhBMP-2 scaffolds might provide a solution to issues of tissue necrosis during the regeneration process and therefore might be able to be readily developed into a useful tool for bone repair in the clinic.
- Published
- 2017
9. Thin-film metallic glass: an effective diffusion barrier for Se-doped AgSbTe
- Author
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Chia-Chi, Yu, Hsin-Jay, Wu, Ping-Yuan, Deng, Matthias T, Agne, G Jeffrey, Snyder, and Jinn P, Chu
- Subjects
Article - Abstract
The thermal stability of joints in thermoelectric (TE) modules, which are degraded during interdiffusion between the TE material and the contacting metal, needs to be addressed in order to utilize TE technology for competitive, sustainable energy applications. Herein, we deposit a 200 nm-thick Zr-based thin-film metallic glass (TFMG), which acts as an effective diffusion barrier layer with low electrical contact resistivity, on a high-zT Se-doped AgSbTe2 substrate. The reaction couples structured with TFMG/TE are annealed at 673 K for 8–360 hours and analyzed by electron microscopy. No observable IMCs (intermetallic compounds) are formed at the TFMG/TE interface, suggesting the effective inhibition of atomic diffusion that may be attributed to the grain-boundary-free structure of TFMG. The minor amount of Se acts as a tracer species, and a homogeneous Se-rich region is found nearing the TFMG/TE interface, which guarantees satisfactory bonding at the joint. The diffusion of Se, which has the smallest atomic volume of all the elements from the TE substrate, is found to follow Fick’s second law. The calculated diffusivity (D) of Se in TFMG falls in the range of D~10−20–10−23(m2/s), which is 106~107 and 1012~1013 times smaller than those of Ni [10−14–10−17(m2/s)] and Cu [10−8–10−11(m2/s)] in Bi2Te3, respectively.
- Published
- 2016
10. Effects of let-7b and TLX on the proliferation and differentiation of retinal progenitor cells in vitro
- Author
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Dandan Zhang, Ping Gu, Xuyang Wen, Qing Xie, Ni Ni, Mengyu Zhu, Yuan Deng, Xianqun Fan, Jing Ji, Min Luo, Junzhao Chen, and Zi Wang
- Subjects
Small interfering RNA ,Neurogenesis ,Receptors, Cytoplasmic and Nuclear ,Biology ,Bioinformatics ,Article ,Retina ,Mice ,Neural Stem Cells ,microRNA ,Animals ,Humans ,Progenitor cell ,Cells, Cultured ,Cell Proliferation ,Regulation of gene expression ,Gene knockdown ,Multidisciplinary ,Cell Differentiation ,Neural stem cell ,Cell biology ,MicroRNAs ,Gene Expression Regulation ,Nuclear receptor ,sense organs - Abstract
MicroRNAs manifest significant functions in brain neural stem cell (NSC) self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. Let-7b is expressed in the mammalian brain and regulates NSC proliferation and differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal. Whether let-7b and TLX act as important regulators in retinal progenitor cell (RPC) proliferation and differentiation remains unknown. Here, our data show that let-7b and TLX play important roles in controlling RPC fate determination in vitro. Let-7b suppresses TLX expression to negatively regulate RPC proliferation and accelerate the neuronal and glial differentiation of RPCs. The overexpression of let-7b downregulates TLX levels in RPCs, leading to reduced RPC proliferation and increased neuronal and glial differentiation, whereas antisense knockdown of let-7b produces robust TLX expression,enhanced RPC proliferation and decreased differentiation. Moreover, the inhibition of endogenous TLX by small interfering RNA suppresses RPC proliferation and promotes RPC differentiation. Furthermore, overexpression of TLX rescues let-7b-induced proliferation deficiency and weakens the RPC differentiation enhancement caused by let-7b alone. These results suggest that let-7b, by forming a negative feedback loop with TLX, provides a novel model to regulate the proliferation and differentiation of retinal progenitors in vitro.
- Published
- 2014
- Full Text
- View/download PDF
11. High-mobility graphene on liquid p-block elements by ultra-low-loss CVD growth
- Author
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Jürgen Eckert, Sheng Wang, Mark H. Rümmeli, Lian-Mao Peng, Boya Dai, Jiao Wang, Yuan Deng, Lifang Tan, Lei Fu, Mengqi Zeng, Zishen Li, and Haitao Xu
- Subjects
Electron mobility ,Multidisciplinary ,Materials science ,Graphene ,chemistry.chemical_element ,Nanotechnology ,Chemical vapor deposition ,Block (periodic table) ,Bioinformatics ,Synthesis of graphene ,Article ,law.invention ,Transition metal ,chemistry ,law ,Electronic devices ,Deposition (phase transition) ,Grain boundary ,Gallium - Abstract
The high-quality and low-cost of the graphene preparation method decide whether graphene is put into the applications finally. Enormous efforts have been devoted to understand and optimize the CVD process of graphene over various d-block transition metals (e.g. Cu, Ni and Pt). Here we report the growth of uniform high-quality single-layer, single-crystalline graphene flakes and their continuous films over p-block elements (e.g. Ga) liquid films using ambient-pressure chemical vapor deposition. The graphene shows high crystalline quality with electron mobility reaching levels as high as 7400 cm(2) V(-1) s(-1) under ambient conditions. Our employed growth strategy is ultra-low-loss. Only trace amounts of Ga are consumed in the production and transfer of the graphene and expensive film deposition or vacuum systems are not needed. We believe that our research will open up new territory in the field of graphene growth and thus promote its practical application.
- Published
- 2013
12. Effects of let-7b and TLX on the proliferation and differentiation of retinal progenitor cells in vitro.
- Author
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Ni Ni, Dandan Zhang, Qing Xie, Junzhao Chen, Zi Wang, Yuan Deng, Xuyang Wen, Mengyu Zhu, Jing Ji, Xianqun Fan, Min Luo, and Ping Gu
- Subjects
PROGENITOR cells ,CELL proliferation ,CELL differentiation ,MICRORNA ,NEURAL stem cells ,DEVELOPMENTAL neurobiology ,NUCLEAR receptors (Biochemistry) - Abstract
MicroRNAs manifest significant functions in brain neural stem cell (NSC) self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. Let-7b is expressed in the mammalian brain and regulates NSC proliferation and differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal. Whether let-7b and TLX act as important regulators in retinal progenitor cell (RPC) proliferation and differentiation remains unknown. Here, our data show that let-7b and TLX play important roles in controlling RPC fate determination in vitro. Let-7b suppresses TLX expression to negatively regulate RPC proliferation and accelerate the neuronal and glial differentiation of RPCs. The overexpression of let-7b downregulates TLX levels in RPCs, leading to reduced RPC proliferation and increased neuronal and glial differentiation, whereas antisense knockdown of let-7b produces robust TLX expression,enhanced RPC proliferation and decreased differentiation. Moreover, the inhibition of endogenous TLX by small interfering RNA suppresses RPC proliferation and promotes RPC differentiation. Furthermore, overexpression of TLX rescues let-7b-induced proliferation deficiency and weakens the RPC differentiation enhancement caused by let-7b alone. These results suggest that let-7b, by forming a negative feedback loop with TLX, provides a novel model to regulate the proliferation and differentiation of retinal progenitors in vitro. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
13. High-mobility graphene on liquid p-block elements by ultra-low-loss CVD growth.
- Author
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Jiao Wang, Mengqi Zeng, Lifang Tan, Boya Dai, Yuan Deng, Rümmeli, Mark, Haitao Xu, Zishen Li, Sheng Wang, Lianmao Peng, Eckert, Jürgen, and Lei Fu
- Subjects
GRAPHENE ,CHEMICAL vapor deposition ,FREE electron theory of metals ,ELECTRIC discharges ,ELECTRON mobility ,TRANSITION metals - Abstract
The high-quality and low-cost of the graphene preparation method decide whether graphene is put into the applications finally. Enormous efforts have been devoted to understand and optimize the CVD process of graphene over various d-block transition metals (e.g. Cu, Ni and Pt). Here we report the growth of uniform high-quality single-layer, single-crystalline graphene flakes and their continuous films over p-block elements (e.g. Ga) liquid films using ambient-pressure chemical vapor deposition. The graphene shows high crystalline quality with electron mobility reaching levels as high as 7400 cm
2 V-1 s-1 under ambient conditions. Our employed growth strategy is ultra-low-loss. Only trace amounts of Ga are consumed in the production and transfer of the graphene and expensive film deposition or vacuum systems are not needed. We believe that our research will open up new territory in the field of graphene growth and thus promote its practical application. [ABSTRACT FROM AUTHOR]- Published
- 2013
- Full Text
- View/download PDF
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