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Appearance and increasing development of families with both partners employed is regarded as a social revolution in Iran. There are many pressures in this type of family life due to inefficiency of the traditional opinion about division of labor in family. One of the pressures stems from work-family conflict in which sometimes there is no solution and causes many unpredictable outcomes for social cohesion, family performance, individual work performance and also work alienation. Nowadays employees do not work for living but for a job. Affected by economic, social and organizational determinants, job alienation is presently a threatening and destructive factor in the performance of an organization. Forms of alienation include feeling of lack of discipline and power, absurdity and social isolation. When incorrect and compatible with the individual, the job and leadership style chosen will have adverse effects on the behavior and personality of the individual. If the job is regarded as something external by the individual who undertakes to do it, it will be an alienating job. This study investigates the influence that supportive leadership and job characteristics play in work alienation. Dependent variable (work alienation) is studied in relation with social support, role expectations, role ambiguity, work control and work-family conflict variables. In this way, views of Duxbury and Higgins, Carlson and Bluner have been utilized. [ABSTRACT FROM AUTHOR]