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Start Over Author "Brigitte Pautard" Journal seminars in hematology
2 results on '"Brigitte Pautard"'

1. Use of recombinant factor VIIa (NovoSeven[reg ]) in patients with Glanzmann thrombasthenia

Author

R Musso, Christiane Guthner, Lilian Tengborn, Pia Petrini, Alison Street, Jonathan T. Wilde, Donald S. Houston, Brigitte Pautard, J rgen Ingerslev, Philippe Beurrier, Nathalie Trillot, Gabriele Strauss, A. Karafoulidou, Ian Hann, Lionel de Lumley, Herv Chambost, Stefan Kuhle, Claire Berger, Angela Huth-K hne, Angela Thomas, Christel Van Geet, Roseline d'Oiron, Christine Demers, Man-Chiu Poon, Claude N grier, Jose J. Lorenzo, Natascha Nohe, Pantelis E. Makris, Massimo Morfini, M. Vicariot, Omer Devecioglu, Marie-Fran oise Torchet, Majorlein Peters, Patricia Paugy, Edith Fressinaud, Alain Marqu s-Verdier, Willem Gerrits, Mario von Depka, Howard A. Britton, Mark Winter, and Stefan Lethagen

Subjects
medicine.medical_specialty, biology, Recombinant factor VIIa, business.industry, Internal medicine, Glanzmann thrombasthenia, biology.protein, medicine, In patient, Hematology, business, Gastroenterology
Published
2001
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2. Use of recombinant factor VIIa (NovoSeven) in patients with Glanzmann thrombasthenia

Author

Jose J. Lorenzo, Lionel de Lumley, Ian Hann, R. Musso, Brigitte Pautard, Stefan Kuhle, M. Vicariot, Mark Winter, Jørgen Ingerslev, Stefan Lethagen, Omer Devecioglu, Edith Fressinaud, Roseline d'Oiron, Alison Street, Majorlein Peters, Natascha Nohe, Mario von Depka, Hervé Chambost, Pantelis E. Makris, Angela Huth-Kühne, Jonathan Wilde, Man-Chiu Poon, Patricia Paugy, Howard A. Britton, Massimo Morfini, Willem Gerrits, Christel Van Geet, Donald S. Houston, Marie-Francoise Torchet, Angela Thomas, Christiane Guthner, Alain Marques-Verdier, Claire Berger, Lilian Tengborn, A. Karafoulidou, Pia Petrini, Christine Demers, Philippe Beurrier, Nathalie Trillot, Gabriele Strauss, and Claude Negrier

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Platelet disorder, Factor VIIa, Platelet Transfusion, Surgical prophylaxis, chemistry.chemical_compound, Thrombasthenia, Pregnancy, Internal medicine, medicine, Humans, Platelet, Chemotherapy, Factor VII, biology, business.industry, Coagulants, Pregnancy Complications, Hematologic, Hematology, Recombinant Proteins, Surgery, Platelet transfusion, chemistry, Recombinant factor VIIa, biology.protein, Female, business
Abstract

Recombinant factor VIIa (rFVIIa; NovoSeven ® , Novo Nordisk, Bagsvaerd, Denmark) appears effective and relatively safe for the treatment of bleeding and for surgical prophylaxis in patients with Glanzmann thrombasthenia as reported to the International Registry on rFVIIa and Congenital Platelet Disorders. One of the shortcomings of the Registry data is the heterogeneity of treatment protocol, including dosage, number of doses used, duration of treatment before declaration of failure, and mode of rFVIIa administration (bolus v continuous infusion). The data are not yet sufficient to define optimal regimens for various indications such as the type of bleeding or the type of procedures. The place of this drug compared to platelet transfusion in the overall management of patients with Glanzmann thrombasthenia will need to be determined in relationship to a number of challenges and unresolved issues in the clinical care of these patients. These issues include: how to improve local measures for patients with mucosal bleeds, optimal management of young women during menarche, optimal platelet transfusion regimens for various indications, the relationship between antiplatelet antibodies detected by monoclonal antibody-specific immobilization of platelet antigens (MAIPA) and effectiveness of platelet transfusion, whether there are other biological tests that may correlate with effectiveness of platelet transfusion, and management of pregnancy and delivery regarding antiplatelet immunization.

Published
2001

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