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Objective To describe the currently accepted standard-of-care practice for surgical and medical management of newly diagnosed high-grade glioma. Data Sources Peer-reviewed journals, nationally accepted guidelines, and personal experience of the authors. Conclusion There is a widely accepted standard-of-care treatment protocol for patients with newly diagnosed high-grade glioma that includes maximal safe resection followed by radiation therapy with concurrent and adjuvant temozolomide. The regimen is well-tolerated and side effects are manageable. Implications for Nursing Practice Nurses who are involved in the care of patients with newly diagnosed high-grade glioma should be familiar with the regimen and its side effects to provide crucial patient and caregiver education in an accurate and beneficial manner.