1. Targeted Therapy for Non-Small Cell Lung Cancer
- Author
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McKenna M. Johnson, Marshall L. Spiegel, Zorawar S. Noor, Jonathan W. Goldman, and Amy L. Cummings
- Subjects
Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,Lung Neoplasms ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,medicine.disease_cause ,Targeted therapy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Carcinoma, Non-Small-Cell Lung ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,ROS1 ,Anaplastic lymphoma kinase ,Humans ,Epidermal growth factor receptor ,Molecular Targeted Therapy ,Precision Medicine ,Lung cancer ,Randomized Controlled Trials as Topic ,biology ,business.industry ,Cancer ,medicine.disease ,Precision medicine ,Combined Modality Therapy ,030228 respiratory system ,Mutation ,Practice Guidelines as Topic ,biology.protein ,KRAS ,business ,Genes, Neoplasm - Abstract
Lung cancer is a heterogeneous disease, and the availability of comprehensive genomic profiling has allowed for the characterization of its molecular subtypes. This has increased the ability to deliver “personalized medicines” by tailoring therapies to target driver mutations in a patient's cancer. The development of targeted therapies for non-small cell lung cancer (NSCLC) has helped define the era of precision medicine throughout oncology. This article aims to contextualize recent research and provide an updated summary of targeted therapies available for patients with NSCLC. With practitioners and clinical researchers in mind, we note standard of care therapies, important approvals, practice guidelines, and treatments in development. The first section discusses mutations in the epidermal growth factor receptor (EGFR) gene, and the second section examines rearrangements in the anaplastic lymphoma kinase (ALK) and ROS1 fusions. Finally, we explore the rarer molecular alterations in BRAF, RET, MET, HER2, and KRAS. Given the many available therapies, it is important to understand the molecular alterations in NSCLC, and how to target them.
- Published
- 2020