1. Myocardial preservation: controlled reperfusion
- Author
-
Parimala Prasanna Simha and Prasanna Simha Mohan Rao
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Ischemia ,Myocardial Reperfusion ,Myocardial Reperfusion Injury ,Internal medicine ,medicine ,Humans ,Cardiac Surgical Procedures ,Cardioplegic Solutions ,Coronary flow ,business.industry ,fungi ,General Medicine ,medicine.disease ,Cardiac surgery ,Aortic cross-clamp ,medicine.anatomical_structure ,Treatment Outcome ,Anesthesia ,Vascular resistance ,Cardiology ,Heart Arrest, Induced ,Myocardial preservation ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Perfusion ,Reperfusion injury - Abstract
Reperfusion injury after reestablishing coronary flow by releasing the aortic cross clamp after cardiac surgery with cardioplegic arrest causes myocardial damage and even death. Attenuation of this reperfusion response by controlling the biochemical and physical environment can avoid morbidity and mortality. Use of a warm reperfusate with addition of drugs that are known to decrease reperfusion injury with manipulation of coronary vascular resistance and the physical parameters of the reperfusion environment helps the heart to reestablish coronary perfusion while decreasing the harm produced by the period of ischemia that occurs during cardiac surgery with intermittent cardioplegic arrest.
- Published
- 2011