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Rapid and efficient assessment of cultivated land quality (CLQ) using remote sensing technology is of great significance for protecting cultivated land. However, it is difficult to obtain accurate CLQ estimates using the current satellite-driven approaches in the pressure-state-response (PSR) framework, owing to the limitations of linear models and CLQ spectral indices. In order to improve the estimation accuracy of CLQ, this study used four evaluation models (the traditional linear model; partial least squares regression, PLSR; back propagation neural network, BPNN; and BPNN with genetic algorithm optimization, GA-BPNN) to evaluate CLQ for determining the accurate evaluation model. In addition, the optimal satellite-derived indicator in the land state index was selected among five vegetation indices (the normalized vegetation index, NDVI; enhanced vegetation index, EVI; modified soil-adjusted vegetation index, MSAVI; perpendicular vegetation index, PVI; and soil-adjusted vegetation index, SAVI) to improve the prediction accuracy of CLQ. This study was conducted in Conghua District of Guangzhou, Guangdong Province, China, based on Gaofen-1 (GF-1) data. The prediction accuracies from the traditional linear model, PLSR, BPNN, and GA-BPNN were compared using observations. The results demonstrated that (1) compared with other models (the traditional linear model: R2 = 0.14 and RMSE = 91.53; PLSR: R2 = 0.33 and RMSE = 74.58; BPNN: R2 = 0.50 and RMSE = 61.75), the GA-BPNN model based on EVI in the land state index provided the most accurate estimates of CLQ, with the R2 of 0.59 and root mean square error (RMSE) of 56.87, indicating a nonlinear relationship between CLQ and the prediction indicator; and (2) the GA-BPNN-based evaluation approach of CLQ in the PSR framework was driven to map CLQ of the study area using the GF-1 data, leading to an RMSE of 61.44 at the regional scale, implying that the GA-BPNN-based evaluation approach has the potential to map CLQ over large areas. This study provides an important reference for the high-accuracy prediction of CLQ based on remote sensing technology. [ABSTRACT FROM AUTHOR]