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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的　通过根骨系统（IRS）建立三维牙颌模型，观察成人口腔正畸患者无托槽隐形矫治过程中牙根的移 动情况。方法　收集使用无托槽隐形矫治器进行正畸治疗的成人患者7例，共计164颗牙作为研究对象。在矫治前 及矫治中期对患者进行口内扫描及锥形束CT拍摄，通过IRS进行三维牙颌模型重建，并将重建的矫治前牙颌模型、 矫治中期实际牙颌模型以及矫治中期设计模拟牙颌模型导出，采用Geomagic Studio软件进行模型配准。以矫治前 的牙齿作为参考模型对每颗牙齿建立三维坐标系，比较牙根在三维方向（颊舌向、近远中向、垂直向）上的实际移动 量与模拟移动量，计算并比较牙根在三维方向上的移动效率；进一步将牙根移动方向细分为颊向、舌向、近中向、远 中向、压低向、伸长向，比较不同方向牙根的实际移动量与模拟移动量及移动效率。结果　牙根在颊舌向、近远中 向、垂直向及颊向、舌向、近中向、远中向、压低向、伸长向上的模拟移动量均高于实际移动量（P均<0. 05）。牙根移 动效率近远中向高于颊舌向（P<0. 05），垂直向与颊舌向、近远中向牙根移动效率比较差异均无统计学意义；牙根移 动效率颊向高于舌向，压低向高于伸长向（P 均<0. 05），远中向牙根移动效率与近中向比较差异无统计学意义 （P>0. 05）。结论　成人口腔正畸患者无托槽隐形矫治过程中牙根在三维方向上的实际移动量均低于模拟移动量， 牙根在舌向及伸长向的移动较为困难，建议对舌向及伸长向进行过矫治设计以辅助牙根移动。 [ABSTRACT FROM AUTHOR]

目的 观察含白蛋白结合型紫杉醇化疗方案化疗过程中联合口服神效黄芪汤加减方和甲钴胺的乳腺癌 患者周围神经毒性 (CIPN)发生情况, 为神效黄芪汤加减方在CIPN防治中的应用提供参考。方法 收集应用含白蛋白 结合型紫杉醇方案化疗至少6个周期的初治乳腺癌患者90例, 随机分为实验组和对照组, 各45例。自接受含白蛋白 结合型紫杉醇化疗时, 实验组开始口服神效黄芪汤加减方 (黄芪 40 g、人参 5 g、桂枝 10 g、防风 6 g 、白芍 15g、鸡血藤 30 g、鸡矢藤30 g、枳壳10 g、炙甘草6 g)联合甲钴胺片 (0. 5 mg/次, 每天3次), 对照组患者开始口服甲钴胺片, 用法同 实验组。6周期化疗结束时, 比较两组CIPN的发生率。化疗第1、2、3、4、5、6周期结束时, 比较两组周围神经病变程度 [周围神经病变分级 (NCI-CTCAE)、生活质量［体能状态评分 (KPS)]、药物安全性相关指标 [血常规 (白细胞计数、血 红蛋白、血小板计数)及肝功能 (AST、ALT、直接胆红素)]。结果 共入组90例患者, 完成88例, 脱落2例 (均为对照 组, 于第一周期化疗后因个人原因脱离)。与对照组比较, 实验组CIPN的发生率低 (P<0. 05)。前4个化疗周期, 两组 NCI-CTCAE评分比较, P均>0. 05；第5、6化疗周期, 两组NCI-CTCAE评分比较, P均<0. 05。两组KPS评分比较, P均> 0. 05。两组肝肾功能、血常规比较, P均>0. 05。结论 白蛋白结合型紫杉醇化疗方案化疗过程中联合口服神效黄芪 汤加减方和甲钴胺的乳腺癌患者CIPN发生率低于单用甲钴胺；与单用甲钴胺比较, 神效黄芪汤加减方联合甲钴胺口 服对乳腺癌含白蛋白结合型紫杉醇化疗方案所致CIPN的防治作用更优, 可降低CIPN的发生率、减轻CIPN程度。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To compare the repair effects of focused low-intensity pulse ultrasound (FLIPUS) combined with local injection of platelet-rich plasma (PRP) on facial nerve injury in rats. Methods Twenty healthy male SD rats were randomly divided into the model group, PRP group, FLIPUS group, and PRP+FLIPUS group, with 5 rats in each group. We established the right lateral facial nerve injury models in each group, and rats in the PRP group received local injection of 50 µL PRP at the nerve injury site, twice a week； rats in the FLIPUS group received FLIPUS treatment at the site of nerve injury for 10 min, once per day； rats in the PRP+FLIPUS group were treated with local injection of PRP and FLIPUS according to the above method； rats in the model group were not subject to special treatment； and the treatment period for each group was 28 d. Behavioral assessments were conducted weekly after surgery in each group, and scores of beard movement and blink reflex were recorded. Before and on the 28th day after surgery, right lateral nerve electrophysiological examination was performed using an electromyography evoked potential device in each group. The maximum CMAP amplitude of the injured facial nerve was recorded and the R value was calculated. After rats of each group were euthanized, the injured facial nerve segment tissues were taken and stained with HE for histopathological observation. At the same time, the average number, diameter, and area of axons per unit area were recorded. Results There were no significant differences in the blink reflex or beard movement scores in rats at 1-4 weeks after surgery between groups (all P> 0. 05). Compared with the same group before surgery, the maximum CMAP amplitude of facial nerve injury in rats of each group decreased after surgery (P<0. 05), and there were no significant differences among all groups after operation (all P> 0. 05). Compared with the model group, the R values of the injured facial nerves in the PRP group, FLIPUS group, and PRP+FLIPUS group all increased (all P<0. 05), while there was no statistically significant difference between the PRP group, FLIPUS group, and PRP+FLIPUS group (all P>0. 05). Compared with the model group, the PRP group, FLIPUS group, and PRP+FLIPUS group showed reduced degree of nerve bundle degeneration, demyelination, and axonal vacuolization, increased number of regenerated axons, and more orderly arrangement of nerve fibers. Compared with the model group, the number of axons per unit area in the injured facial nerve segment tissue of rats in the PRP group, FLIPUS group, and PRP+FLIPUS group increased (all P<0. 05）； the axon diameter and area per unit area of the injured facial nerve segment tissue in the PRP group rats were higher than those in the model group, FLIPUS group, and PRP+FLIPUS group (all P<0. 05). Conclusion The repair effect of FLIPUS combined with local injection of PRP on facial nerve injury in rats is not superior to that of FLIPU and PRP alone. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的　探讨伊立替康联合紫杉醇治疗铂类耐药型进展期胃癌患者的临床疗效。方法　选取铂类耐药型 进展期胃癌患者94例，采用随机数字表法分为对照组和观察组各47例。对照组伊立替康联合氟尿嘧啶治疗，观察 组伊立替康联合紫杉醇治疗，3周为1个周期，共治疗3个周期。治疗期间对照组1例病死、1例主动退出研究，观察 组 2 例病死，最终两组各有 45 例患者完成本次研究。治疗前及治疗 3 个周期检测两组患者血清糖类抗原 724 (CA724)、糖类抗原125(CA125)、糖类抗原199(CA199)肿瘤标志物水平，观察两组近期临床疗效、不良反应发生情 况；治疗结束后对患者进行为期1年的跟踪随访，以肿瘤复发或病死作为随访终点事件，比较两组随访期间肿瘤复 发率和生存率。结果　与治疗前比较，两组治疗 3 个周期后血清 CA724、CA125、CA199 水平均降低(P 均<0. 05)。 治疗 3个周期比较，两组血清 CA724、CA125、CA199水平以及疾病总缓解率差异无统计学意义(P均>0. 05)。治疗 期间，观察组白细胞减少、血小板减少及血红蛋白减少程度较对照组减轻(P<0. 05)。随访1年，观察组生存率高于 对照组(P<0. 05)。结论　伊立替康联合紫杉醇治疗铂类耐药型进展期胃癌可获得与传统治疗方案同等的近期临 床疗效，而且可降低患者血液系统不良反应分级，提高患者生存率。 [ABSTRACT FROM AUTHOR]

目的　观察急性脑梗死患者血清微小RNA-133（miR-133)、微小RNA-335（miR-335)水平变化，分析血清 miR-133、miR-335 水平与磷酸肌醇-3-激酶（PI3K)/苏氨酸蛋白激酶（AKT)信号通路相关分子表达和预后的关系。 方法　选择 112例急性脑梗死患者纳入病例组，另选 115例健康志愿者纳入对照组。采用实时逆转录 PCR法检测 血清miR-133、miR-335，采用荧光定量PCR法检测外周血单个核细胞（PMBC)中的PI3K、AKT、哺乳动物雷帕霉素靶 蛋白（mTOR)mRNA，采用Western blotting法检测PMBC中的PI3K、AKT、mTOR蛋白。采用Pearson法分析血清miR133、miR-335水平与 PMBC中 PI3K、AKT、mTOR mRNA 及蛋白表达的关系。病例组采用重组组织型纤溶酶原激活 剂静脉溶栓治疗，随访90 d，根据改良Rankin量表评分评估患者预后，采用多因素Logistic回归分析筛选急性脑梗死 患者预后不良的影响因素。结果　病例组血清 miR-133 水平高于对照组，miR-335 水平及 PMBC 中 PI3K、AKT、 mTOR mRNA和蛋白相对表达量均低于对照组（P均<0. 05)。病例组miR-133水平与PI3K、AKT、mTOR mRNA及蛋 白表达呈负相关（P均<0. 01)，miR-335水平与PI3K、AKT、mTOR mRNA及蛋白表达呈正相关（P均<0. 01)。病例组 预后不良发生率为22. 32%，预后不良的影响因素包括吸烟或饮酒史、合并高血压/糖尿病/高脂血症、入院时美国国 立卫生院卒中量表评分及血清 miR-133、miR-335 水平（P 均<0. 05)。结论　急性脑梗死患者血清 miR-133 水平升 高、miR-335水平降低，血清 miR-133、miR-335水平与 PMBC中 PI3K/AKT信号通路相关分子表达存在相关性，miR133、miR-335为急性脑梗死患者预后不良的影响因素。 [ABSTRACT FROM AUTHOR]

目的　通过检测前列腺癌 (PCa) 患者血清前列腺特异性抗原 (PSA) 、转化生长因子β (1 TGF-β1 ) 、尿激酶型 纤溶酶原激活物 (uPAR) 、α甲基酰基辅酶A消旋酶 (AMACR) 和尿肌氨酸水平, 探讨上述指标在前列腺癌诊断中的 效能。方法　选取PCa患者80例为PCa组, 同时按1:1选取前列腺良性增生患者及体检健康者分别作为良性增生 组及健康对照组。采用ELISA法检测血清TGF-β1、uPAR、AMACR, 电化学发光法检测血清PSA, 同位素稀释液相色 谱质谱法测定尿沉渣中的肌氨酸；对比各指标在三组间及不同临床病理特征PCa患者间的差异, 采用受试者工作特 征 (ROC) 曲线分析各指标单项与联合对PCa的诊断价值。结果 PCa组血清PSA、TGF-β1、uPAR、AMACR及尿肌氨 酸水平均高于良性增生组和健康对照组, 且良性增生组高于健康对照组 (P均<0. 05) 。PCa患者血清PSA、TGF-β1、 uPAR及尿肌氨酸水平均随Gleason评分及TNM分期升高而逐渐升高 (P均<0. 05), 且有骨转移者血清PSA、TGF-β1、 uPAR、AMACR 及尿肌氨酸水平均高于无骨转移者 (P均<0. 05) 。单项检测时, AMACR 诊断 PCa的约登指数、灵敏 度及准确度最高, 尿肌氨酸诊断的 ROC曲线下面积 (AUC) 及特异度最高; 各指标联合检测对 PCa诊断的 AUC明显 高于各单项检测 (P均<0. 05) 。结论 PCa患者血清TGF-β1、uPAR、AMACR及尿肌氨酸水平升高, 且随病情加重升 高越明显；各指标对PCa均有一定诊断价值, 但联合诊断效能最高。 [ABSTRACT FROM AUTHOR]

色谱质谱联用技术可以识别2型糖尿病发生发展过程中的潜在生物标志物，如甘氨酸, 赖氨酸和反式肉 桂酸可能是2型糖尿病前期的潜在生物标志物；4-羟基苯甲酸, 腺苷, 1-阿拉伯糖, 1-天冬氨酸及加拉基酸可作为糖 尿病肾病的潜在生物标志物，不仅为2型糖尿病的早期诊断及并发症预测提供参考依据，还有利于指导临床及早介 入干预手段, 控制疾病发展。色谱质谱联用技术可以识别不同中医证候的潜在生物标志物，如乙醇胺, 溶血磷脂酰 胆碱可作为2型糖尿病上热下寒证的潜在生物标志物；磷脂酰甘油, 鞘磷脂和溶血磷脂酰乙醇胺可作为2型糖尿病 肾病Ⅲ期气阴两虚证的潜在生物标志物，为中医证候分类提供客观化, 科学化的参数指标，从而有利于指导中医临 证，提高临床疗效。色谱质谱联用技术可以识别药物代谢通路, 监测药物作用途径，如黄芩可以调节三羟基三甲基 吲哚酮, 白三烯, 亮氨酰脯氨酸和雌二醇等代谢产物，从而干预鞘脂类代谢和脂肪酸代谢；葛根芩连汤可以调节胆汁 酸代谢, 磷脂代谢以及肠道菌群代谢，这使得中药在人体的作用机制更加可视化, 微观化，既为临床精准用药提供了 可能，也为未来挖掘具有降糖作用的中药或中成药提供有力工具. [ABSTRACT FROM AUTHOR]

Objective The levels and grades of plasma vitamin A in healthy children and children with recurrent respiratory tract infection at different age were observed. Methods Totally 67 784 children aged from 6 months to 14 years for treatment and health check-up［There were 45 188 cases in healthy children group (no recurrent respiratory tract infection and no other symptoms) and 22 596 cases in children with recurrent respiratory tract infection group］were divided into infant group (6 months to 3 years old), preschool group (3 to 6 years old), school age group (6 to 12 years old) and adolescent group (12 to 14 years old). The finger blood or venous blood of children in two groups were collected. Determination of plasma vitamin A by high-performance liquid chromatography fluorescence assay was performed. Plasma vitamin A level<0. 2 mg/L was defined as sub-clinical deficiency, 0. 2-0. 3 mg/L as suspicious sub-clinical deficiency, 0. 3-0. 5 mg/L as normal, and ≥0. 5 mg/L as high level. Plasma vitamin A levels and grades in healthy and respiratory tract infection children of all ages were compared, and analyzed the effects of age and respiratory tract infection on vitamin A levels in children. Results Plasma vitamin A levels in 22 596 children with recurrent respiratory tract infection were (0. 276 ± 0. 001) mg/L, and the plasma vitamin A level in 45 188 healthy children was (0. 324 ± 0. 001) mg/L (P<0. 05). In all age groups, vitamin A levels in children with repeated respiratory tract infection were lower than those in healthy children (all P<0. 01) . Sub-clinical deficiency accounted for 20. 0%, suspicious sub-clinical deficiency accounted for 42. 2%, normal accounted for 36. 0%, and high level accounted for 1. 85% of children with recurrent respiratory tract infection. Sub-clinical deficiency accounted for 14. 1%, suspicious sub-clinical deficiency accounted for 35. 3%, normal accounted for 46. 2% and high level accounted for 4. 43% of healthy children (P<0. 01)；and vitamin A levels and grades in children with repeated respiratory tract infection in all age groups were significantly lower than those in healthy children (all P< 0. 01) . Both age and respiratory tract infection affect vitamin A levels in children. Conclusions In all age groups, plasma vitamin A levels in children with recurrent respiratory tract infection were lower than those in healthy children, and the prevalence of sub-clinical vitamin A deficiency and suspicious sub-clinical vitamin A deficiency was higher than those in healthy children. Repeated respiratory tract infection in children might be related to vitamin A deficiency. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探讨药物涂层球程(DCB)用于冠状动脉大血管原位原发病变介入治疗的临床效果。 方法 选择 行介人治疗的冠状动脉大血管原位原发病变患者159 例，其中行DCB介入治疗56例(DCB组）、行药物洗脱支架 (DES)介入治疗103例(DES组）。 两组术前、术后即刻、术后6个月行冠状动脉造影检查，以导管直径为参考，采 用定量CAG分析软件浏最冠状动脉靶血管病变处最小管腔直径（MLD) ，计算管腔狭窄程度和术后6个月晚期管 腔丢失(LLL) 。 统计两组术后6个月内主要不良心血忤事件(MACE)和靶血管病变处再狭窄悄况。 结果 两组术 后即刻与术后6个月 MLD 较术前升商，管腔狭窄程度较术前降低(P均<0.05)；两组术后即刻与术后6个月 MLD、管腔狭窄程度比较P均＞0.05;DCB组术后即刻MLD低于DES组，管腔狭窄程度高于DES组(P均< 0.05)。 DCB组术后6个月 LLL低千DES组(P<0. 05)。 两组术后6个月内MACE和靶血管再狭窄的发生率比较 P均＞0.05。 结论 DCB用于冠状动脉大血管原位原发病变介人治疗安全有效，并能明显降低靶病变LLL。 [ABSTRACT FROM AUTHOR]

近年来代谢手术作为治疗 2 型糖尿病的一种方法巳逐步应用于临床，并取得了满意的临床效果。 研究 表明，代谢手术可通过影响神经调节、减少热量摄入、改变生长激素释放肤分泌、升高胰高血糖索样肤 1 及肤 YY 水 平、增加循环胆汁酸、减少炎症因子生成及调节肠道菌群 ，从而增加胰岛素分泌、提高胰岛索敏感性，达到改善糖代 谢的 目的。 [ABSTRACT FROM AUTHOR]

观察宫颈癌组织中微小 RNA-181a( miR-181a汃葡萄糖调节蛋白 78(GRP78) mRNA 的表达变化， 并探讨其临床意义。 方法 宫颈癌患者93 例、子宫肌瘤患者 40 例，均接受手术治疗，宫颈癌患者术中留取宫颈癌 组织，子宫肌瘤患者术中留取正常宫颈组织 ，采用 qRT-PCR 法检测宫颈癌组织及正常宫颈组织中 miR-181a、GRP78 mRNA，分析宫颈癌组织中 lncRNA-PVT1 、miR-31 表达的相关性及其与宫颈癌患者临床病理参数的关系。 以宫颈癌 组织中 miR-181a、GRP78 mRNA 相对表达掘的中位数为临界值，将宫颈癌患者分为 miR-181a 商表达组、miR-181a 低表达组和 GRP78 mRNA 商表达组、GRP78 mRNA 低表达组，分析 miR-181a、GRP78 mRNA 相对表达昼与宫颈癌患 者预后的关系。 结果 宫颈癌组织中 miR-181a 、GRP78 mRNA 相对表达量分别为 0. 524 土 0. 105 、1. 208 土 0. 340 ，正 常宫颈组织中 miR-181a、GRP78 mRNA 相对表达噩分别为 1. 613 土 0.580 、0. 647 土 0. 132，两者相比，P 均 < 0. 05 。 宫 颈癌组织中 miR-181a、GRP78 mRNA 表达呈负相关(r = - 0. 645, P = 0. 000) 。 miR-181a、GRP78 mRNA 表达与宫颈 癌患者肿瘤 FIGO 分期、分化程度有关(P 均<0. 05) 。 miR-18la 商表达组 3 年总体生存率( OS) 为 84. 4%, miR181a 低表达组 3 年 OS 为 79. 1% ，两组相比，P > 0. 05 。 GRP78 mRNA 商表达组 3 年 OS为 67.4%,GRP78 mRNA 低 表达组 3年 OS 为 96. 7% ，两组相比，P <0. 05 。 结论 宫颈癌组织中 miR-181a 低表达、GRP78 mRNA 商表达，miR181a 与 GRP78 mRNA 表达呈负相关关系 ， miR-181a 及 GRP78 mRNA 表达与宫颈癌 FIGO 分期、分化程度有关， GRP78 mRNA 高表达的官颈癌患者术后生存率低。 [ABSTRACT FROM AUTHOR]

目的 探讨子宫内膜癌组织微小RNA-135b(miR-135b)、同源盒基因家族A10(HOXA10)表达变化及其与患者临床病理特征的关系.方法 选择子宫内膜癌患者73例,取手术切除的子宫内膜癌组织及其配对的癌旁正常组织,采用real-time PCR法检测miR-135b、HOXA10表达,观察子宫内膜癌组织miR-135b、HOXA10表达变化.分析子宫内膜癌组织miR-135b表达与HOXA10表达的关系及其与患者临床病理特征的关系.结果 与癌旁正常组织比较,子宫内膜癌组织miR-135b相对表达量明显升高,HOXA10相对表达量明显降低(P均<0.01).Pearson相关分析显示,子宫内膜癌组织miR-135b相对表达量与HOXA10相对表达量呈负相关关系(r=-0.496,P<0.01).子宫内膜癌组织miR-135b、HOXA10相对表达量均与肿瘤浸润深度、FIGO分期、淋巴结转移有关(P均<0.05),而与患者年龄、绝经状态、病理类型、病理分级无关(P均>0.05).结论 子宫内膜癌组织miR-135b高表达、HOXA10低表达,二者表达变化与肿瘤恶性进展有关;下调HOXA10表达可能是miR-135b参与子宫内膜癌形成和恶性进展的机制之一. [ABSTRACT FROM AUTHOR]

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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

托鐽非編碼 RNA(lncRNA)是一奕辰度大于200 令核苷酸的非編碼 RNA 分子，越米越多的lncRNA 被证 实在小细胞肺癌 (SCLC) 中昇常表迏。研究岌現，lncRNA 在 SCLC 友生岌展、特移和耐葯辺程中友摔着重要调控作 用，可为 SCLC 早期笳查与銪移、预后讠平估提供新造拌，并为逆特 SCLC 化庁耐葯提供新靶熹。 [ABSTRACT FROM AUTHOR]

目的 观察神经节昔脂钠辅助治疗急性缺血性卒中的临床效果。方法 选取急性缺血性卒中患者 84 例, 根据随机数字表法将患者分为观察组、对照组各 42 例。两组入院后给予常规治疗，对照组静脉滴注丁苯猷氯 化钠注射液1 00mL /次，2 次Id。治疗组在对照组治疗基础上加神经节昔脂钠20mg/d,1次或分次肌注或缓慢静脉 滴注。两组均治疗2周。 治疗前后采用美匡匡立卫生研究院卒中噩表 (NHISS) 评分评估两组神经功能缺损程度，用 B arthel 指数评分 (BI 评分）评估两组日常生活活动能力，用酶联免疫吸附法检测血清Tau 蛋白，根据治疗后 NHISS评分下降幅度评价疗效，统计两组治疗期间发生的不良反应。 结果 治疗后两组 NIHSS 评分均较治疗前降 低，BI 评分及血清Tau蛋白水平均较治疗前升高，比较差异有统计学意义 (P 均<0.05)；治疗后观察组 NIHSS 评分 低于对照组，BI评分及庄清 Tau 蛋白水平高于对照组，比较差异有统计学意义(P均<0.05)。 治疗后对照组痊愈 10例、显效10例、有效14例、无效8例 ，总有效率为76.20% ；观察组痊愈15 例、显效 15例、有效 9 例、无效 3 例，总 有效率为 92.86%。观察组总有效率商于对照组 (P<0. 05)。治疗期间对照组发生嗜睡2例、恶心 3 例 、头垒 3例 ， 共 8 例；观察组发生嗜睡 2 例、恶心 3 例 、头辇1例 ，共 5 例 。两组不良反应发生率比较差异无统计学意义 (P 0.05)。结论 神经节昔脂钠可改善急性缺血性卒中患者神经功能、日常生活活动能力及脑组织损伤，疗效佳，且 安全性较高。 [ABSTRACT FROM AUTHOR]

目的观察芍药苷（PF)对银屑病小鼠皮损的治疗作用，并探讨其机制. 方法将40只小鼠随机分为4 组，每组10只。各组将小鼠背部毛发全部剔光，用Na2S擦拭。A组小鼠背部每天涂抹凡士林，连续涂抹7 d;B、C、 D组小鼠均先用咪喹莫特擦拭7 d(银屑病造模），B、C组分别腹腔注射生理盐水、PF 10 d，D组腹腔注射PF后6 h 背部皮下注射重组血管内皮生长因子(VEGF)蛋白10 d。治疗第18天处死小鼠，收集皮损组织及外周血标本;行 HE染色观察皮损病理变化并计数血管数，用ELISA法检测外周血VEGF蛋白，RT-PCR法检测皮损组织中的VEGF 及其受体VEGFR1、VEGFR2基因。结果 A组皮损组织未见病理学异常，B、D组皮损组织具有典型的银屑病样病 理特征，C组皮损组织银屑病样病理特征减轻;B组皮损组织中血管数、外周血VEGF蛋白水平高于A、C、D组（P 均<0.05)，D组高T C组但无统计学差异。B组皮损组织中VEGF、VEGFR1、VEGFR2 mRNA表达量高于A、C组 (P均<0.05)，D组皮损组织中VEGF、VEGFR1、VEGFR2 mRNA表达量高于C组(P均<0.05) 结论PF对小鼠 银屑病有积极治疗作用，1 j其抑制VEGF及相应受体表达抗血管增生有关。 [ABSTRACT FROM AUTHOR]

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目的探讨宫颈癌组织中组织因子途径抑制物-2 (TFPI-2)表达变化，及其与宫颈癌组织血管内皮生长因 子(VEGF)表达、微血管密度（MVD)的相关性。方法选取80例宫颈癌患者的宫颈癌组织标本为宫颈癌组，50例 宫颈上皮内瘤变（CIN)患者CIN组织标本为CIN组，20例正常体检者的正常宫颈组织标本为对照组。采用免疫组 化SP法对三组标本行TFPI-2、VEGF、CD34染色，半定量观察TFPI-2、VEGF表达情况，用CD34染色切片测算微血管 密度（MVD) :结果宫颈癌组、CIN组、对照组TFPI-2阳性表达率分别为21.25% (17/80)、52.00% (26/50)和 85.00% (17/20)，宫颈癌组TFPI-2阳性表达率与CIN组、对照组相比，P均< 0.05; CIN组TFPI-2阳性表达率与对 照组相比，P均< 〇.05。宫颈癌组、CIN组、对照组VEGF阳性表达率分别为72.50% (58/80)、42.00% (21/50)和 10.00% (2/50)，宫颈癌组VEGF阳性表达率与CIN组、对照组相比，P均<0.05 ;CIN组VEGF阳性表达率与对照 组相比，P均<0.05。宫颈癌组、CIN组、对照组MVD分别为（22±8)、（10士2)、（6±2)条/HP，宫颈癌组MVD与 CIN组、对照组相比，P均<0.05 ;CIN组MVD与对照组相比，P均<0.05。Spearman等级相关性分析结果显示，宫 颈癌组标本 TFPI-2 蛋VEGF白表达、MVD 河¥0均呈负相关卜分别为-0.632、-0.685，尸均<0.05)。结论宫颈 癌组织中TFPI-2蛋白低表达。宫颈癌组织中TFPI-2表达与VEGF表达和MVD呈负相关。宫颈癌组织中TFPI-2 可能通过下调VEGF表达抑制肿瘤新生血管形成。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

摘要：目的　探讨两种剂量（２０、４０ ｍｇ）阿托伐他汀对经皮冠状动脉介入术（ＰＣＩ）后患者超敏Ｃ 反应蛋白（ｈｓ-ＣＲＰ）、脂联素（ＡＰＮ）、网膜素１（ＯＥ-１）等炎性因子水平及主要不良心血管事件（ＭＡＣＥ）的影响。方法　选取行ＰＣＩ 术患者１１１ 例，随机分为Ａ、Ｂ 组，分别于入院时服用阿托伐他汀４０、２０ ｍｇ/ｄ。检测入院（未服药）时、术后３ ｄ、术后３ 个月的血脂及ｈｓ-ＣＲＰ、ＡＰＮ、ＯＥ-１；随访３ 个月统计药物不良反应及随访１ 年ＭＡＣＥ。结果　术后３ 个月两组ＴＣ、ＴＧ 水平均较入院前降低（Ｐ 均<０．０５），且Ａ 组低于Ｂ 组（Ｐ 均< ０．０５）。术后３ ｄ、３ 个月两组血清ｈｓ-ＣＲＰ水平均较入院前降低，血清ＡＰＮ、ＯＥ-１ 水平均较入院前升高（Ｐ 均< ０．０５）。且术后３ 个月Ａ 组血清ｈｓ-ＣＲＰ 水平低于Ｂ 组，血清ＡＰＮ、ＯＥ-１ 水平高于Ｂ 组（Ｐ 均<０．０５）。两组不良反应发生率比较差异无统计学意义（Ｐ ＞０．０５），ＭＡＣＥ 发生率比较差异有统计学意义（Ｐ < ０．０５）。结论　２０、４０ ｍｇ 阿托伐他汀均能降低ＰＣＩ 术后患者血清ｈｓ-ＣＲＰ 水平，升高ＡＰＮ、ＯＥ-１ 水平，降低ＭＡＣＥ 发生率，但４０ ｍｇ 阿托伐他汀效果更佳。 [ABSTRACT FROM AUTHOR]

目的探讨血小板反应蛋白l(TSP-l)对动脉粥样硬化（AS)大鼠血浆氧化型低密度脂蛋白（ox-LDL)的 影响。方法采用高脂饮食法建立AS模型大鼠50只，随机分为对照组、TSP-1重组体组、空质粒组、TSP-1 siRNA + TSP-1重组体组、TSP-1 SiRNA +空质粒组，每组10只。对照组不干预，TSP-1重组体组尾静脉注射TSP-1重组体 细胞悬液0.25 μL，空质粒组尾静脉注射空质粒细胞悬液0.25 μL，TSP-l siRNA+TSP-1重组体组尾静脉注射TSP-1 siRNA +TSP-1重组体0.25 μL TSP-1 siRNA+空质粒组尾静脉注射TSP-1 siRNA +空质粒0.25 μL。各组干预后 常规饲料喂养至第15周，心脏取血，采用ELISA法检测血浆ox-LDL;断颈处死，取胸主动脉，采用免疫荧光技术检 测斑块内部TSP-1表达。结果TSP-1重组体组、空质粒组、TSP-1 siRNA+TSP-1重组体组、TSP-1 SiRNA +空质粒 组血浆ox-LDL水平依次降低，且均高于对照组（P均<0.05)。TSP-1重组体组TSP-1表达最高，明显高于对照组 (P<0.05);空质粒组、1通似+11重组体组〇-1通似+空质粒组了3-1表达依次降低，且均低于对照 组（P均<0.05)。相关分析显示，TSP-1表达与血浆 ox-LDL 水平呈正相关（r=0.417, P<0.05)。结论TSP-1可 促进AS大鼠血浆ox-LDL水平升高，对AS的发生、发展起促进作用。 [ABSTRACT FROM AUTHOR]

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目的 观察并分析单胎孕妇孕前 BMI 及产次对孕期增重的影响。方法收集2013年9月～2014年4月在郑州大学第三附属医院分娩的1252例孕妇的临床资料。采用 χ2检验比较不同年龄、文化程度、孕前 BMI、产次、孕周及分娩方式的孕妇孕期增重情况，采用无序多分类 Logistic 回归分析法分析孕前 BMI、产次与孕期增重的关系。结果1252名孕妇中，孕前消瘦者孕期增重适宜的比例高于孕前超重及肥胖者（P ＜0．01），孕期增重过多的比例低于孕前超重及肥胖者（P ＜0．01）；孕前 BMI 正常者孕期增重过多的比例也低于孕前超重及肥胖者（P ＜0．01）。经产者孕期增重不足和增重适宜的比例均低于初产者（P ＜0．01），孕期增重过多的比例高于初产者（P ＜0．01）。调整年龄、文化程度后，与初产妇相比，经产妇孕前消瘦风险降低（OR ＝0．393，95％CI：0．260～0．594），但孕前超重及肥胖的风险升高（OR ＝2．050，95％CI：1．368～3．072）。将产次分层后，孕前超重及肥胖的初产妇发生孕期增重过多的风险高于孕前 BMI 正常者（OR ＝5．378，95％CI：2．424～11．913）。将孕前 BMI 分层后，孕前 BMI正常的经产妇孕期增重过多的风险高于初产妇（OR ＝1．771，95％CI：1．287～2．437）；孕前超重及肥胖的经产妇孕期增重不足的风险低于初产妇（OR ＝0．216，95％CI：0．065～0．718）。结论初产妇和经产妇孕期增重过多比例均较高；孕前 BMI 和产次是孕期增重的独立影响因素；相比孕前 BMI 正常者，孕前超重和肥胖的初产妇孕期增重过多的风险更大；经产会增加孕期增重过多的风险，同时降低孕期增重过少的风险。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的探讨β-链蛋白(β-catenin)、细胞周期蛋白(cyclin D1)及周期蛋白依赖性激酶4(CDK4)在乳腺浸润性导管癌发生、发展中的作用。方法 154例乳腺浸润性导管癌石蜡标本依据St.Gallen标准分为腔上皮A型(Luminal A型)15例、Luminal B型88例、人表皮生长因子受体(HER-2)过表达型27例、三阴型24例。采用免疫组化En Vision法检测154例标本β-catenin、cyclin D1、CDK4的表达水平并分析其与临床病理特征的关系。结果 154例标本中β-catenin的异常表达率为55.19%(85/154),cyclin D1阳性表达率为55.19%(85/154),CDK4阳性表达率为52.60%(81/154)。Luminal A型、Luminal B型cyclin D1阳性表达率明显高于其他型,三阴型CDK4的阳性表达率明显高于其他型。β-catenin、cyclin D1表达与各临床病理特征无关,CDK4表达与肿瘤直径、组织分级、淋巴结转移相关。结论 CDK4在乳腺浸润性导管癌癌发生及发展中起促进作用,可作为评价其转移、预后的重要因子。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的：探讨视神经减压术前闪光视觉诱发电位（FVEP）与外伤性视神经病（TON）预后的关系。方法 收集52例（52眼）TON患者术前FVEP检查资料，并随访患者术后视力变化，分析二者相关性。结果 52例TON患者按照术前VEP波形分析分为观察组28例（28眼，术前FVEP检测能引出P2波）和对照组24例（24眼，术前FVEP检测不能引出P2波）。观察组术后有效19眼，无效9眼；对照组术后有效8眼，无效16眼；两组有效者比较，P＜0．05。观察组P2波潜伏期轻度延长7眼，其中术后有效7眼；潜伏期中度延长10眼，其中术后有效8眼；潜伏期重度延长11眼，其中有效4眼；轻、中度延长者与重度延长者比较，P均＜0．05。观察组P2波波幅轻度下降9眼，其中有效7眼；波幅中度下降6眼，其中有效4眼；波幅重度下降13眼，其中有效7眼；两两比较， P均＞0．05。结论 TON患者术前FVEP表现对评价患者预后有重要作用，可以作为评判TON预后的客观指标。 [ABSTRACT FROM AUTHOR]