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27 results on '"Georgieff, Michael"'

1. The Mitochondria-Targeted H2S-Donor AP39 in a Murine Model of Combined Hemorrhagic Shock and Blunt Chest Trauma

Author

Wepler, Martin, Merz, Tamara, Wachter, Ulrich, Vogt, Josef, Calzia, Enrico, Scheuerle, Angelika, Möller, Peter, Gröger, Michael, Kress, Sandra, Fink, Marina, Lukaschewski, Britta, Rumm, Grégoire, Stahl, Bettina, Georgieff, Michael, Huber-Lang, Markus, Torregrossa, Roberta, Whiteman, Matthew, McCook, Oscar, Radermacher, Peter, and Hartmann, Clair

Published
2019
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7. Metabolic, Cardiac, and Renal Effects of the Slow Hydrogen Sulfide-Releasing Molecule GYY4137 During Resuscitated Septic Shock in Swine with Pre-Existing Coronary Artery Disease

Author

Nußbaum, Benedikt L., primary, Vogt, Josef, additional, Wachter, Ulrich, additional, McCook, Oscar, additional, Wepler, Martin, additional, Matallo, José, additional, Calzia, Enrico, additional, Gröger, Michael, additional, Georgieff, Michael, additional, Wood, Mark E., additional, Whiteman, Matthew, additional, Radermacher, Peter, additional, and Hafner, Sebastian, additional

Published
2017
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8. The Role of Cystathionine-γ-Lyase In Blunt Chest Trauma in Cigarette Smoke Exposed Mice

Author

Hartmann, Clair, primary, Hafner, Sebastian, additional, Scheuerle, Angelika, additional, Möller, Peter, additional, Huber-Lang, Markus, additional, Jung, Birgit, additional, Nubaum, Benedikt, additional, McCook, Oscar, additional, Gröger, Michael, additional, Wagner, Florian, additional, Weber, Sandra, additional, Stahl, Bettina, additional, Calzia, Enrico, additional, Georgieff, Michael, additional, Szabó, Csaba, additional, Wang, Rui, additional, Radermacher, Peter, additional, and Wagner, Katja, additional

Published
2017
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9. Association of Kidney Tissue Barrier Disrupture and Renal Dysfunction in Resuscitated Murine Septic Shock

Author

Stenzel, Tatjana, primary, Weidgang, Clair, additional, Wagner, Katja, additional, Wagner, Florian, additional, Gröger, Michael, additional, Weber, Sandra, additional, Stahl, Bettina, additional, Wachter, Ulrich, additional, Vogt, Josef, additional, Calzia, Enrico, additional, Denk, Stephanie, additional, Georgieff, Michael, additional, Huber-Lang, Markus, additional, Radermacher, Peter, additional, and McCook, Oscar, additional

Published
2016
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10. The Mitochondria-Targeted H2S-Donor AP39 in a Murine Model of Combined Hemorrhagic Shock and Blunt Chest Trauma.

Author

Wepler, Martin, Merz, Tamara, Wachter, Ulrich, Vogt, Josef, Calzia, Enrico, Scheuerle, Angelika, Moller, Peter, Groger, Michael, Kress, Sandra, Fink, Marina, Lukaschewski, Britta, Rumm, Gregoire, Stahl, Bettina, Georgieff, Michael, Huber-Lang, Markus, Torregrossa, Roberta, Whiteman, Matthew, McCook, Oscar, Radermacher, Peter, and Hartmann, Clair

Published
2019
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11. Physiological and Immune-Biological Characterization of a Long-Term Murine Model of Blunt Chest Trauma

Author

Hafner, Sebastian, primary, Wagner, Katja, additional, Wepler, Martin, additional, Matallo, José, additional, Gröger, Michael, additional, McCook, Oscar, additional, Scheuerle, Angelika, additional, Huber-Lang, Markus, additional, Frick, Manfred, additional, Weber, Sandra, additional, Stahl, Bettina, additional, Jung, Birgit, additional, Calzia, Enrico, additional, Georgieff, Michael, additional, Möller, Peter, additional, Dietl, Paul, additional, Radermacher, Peter, additional, and Wagner, Florian, additional

Published
2015
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12. Temperature and Cell-Type Dependency of Sulfide Effects on Mitochondrial Respiration

Author

Groeger, Michael, primary, Matallo, Jose, additional, McCook, Oscar, additional, Wagner, Florian, additional, Wachter, Ulrich, additional, Bastian, Olga, additional, Gierer, Saskia, additional, Reich, Vera, additional, Stahl, Bettina, additional, Huber-Lang, Markus, additional, Szabó, Csaba, additional, Georgieff, Michael, additional, Radermacher, Peter, additional, Calzia, Enrico, additional, and Wagner, Katja, additional

Published
2012
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13. Inflammatory Effects of Hypothermia and Inhaled H2S During Resuscitated, Hyperdynamic Murine Septic Shock

Author

Wagner, Florian, primary, Wagner, Katja, additional, Weber, Sandra, additional, Stahl, Bettina, additional, Knöferl, Markus W., additional, Huber-Lang, Markus, additional, Seitz, Daniel H., additional, Asfar, Pierre, additional, Calzia, Enrico, additional, Senftleben, Uwe, additional, Gebhard, Florian, additional, Georgieff, Michael, additional, Radermacher, Peter, additional, and Hysa, Vladislava, additional

Published
2011
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14. Effects of Intravenous Sulfide During Porcine Aortic Occlusion-Induced Kidney Ischemia/Reperfusion Injury

Author

Simon, Florian, primary, Scheuerle, Angelika, additional, Gröger, Michael, additional, Stahl, Bettina, additional, Wachter, Ulrich, additional, Vogt, Josef, additional, Speit, Günter, additional, Hauser, Balázs, additional, Möller, Peter, additional, Calzia, Enrico, additional, Szabó, Csaba, additional, Schelzig, Hubert, additional, Georgieff, Michael, additional, Radermacher, Peter, additional, and Wagner, Florian, additional

Published
2011
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21. EFFECTS OF THE COMBINED THROMBOXANE RECEPTOR ANTAGONIST AND SYNTHASE INHIBITOR DTTX-30 ON INTESTINAL O2-EXCHANGE AND ENERGY METABOLISM DURING HYPERDYNAMIC PORCINE ENDOTOXEMIA

Author

Matejovic, Martin, primary, Radermacher, Peter, additional, Zülke, Carl, additional, Vlatten, Arnim, additional, Altherr, Jürgen, additional, Brinkmann, Alexander, additional, Brückner, Uwe B, additional, Jauch, Karl-Walter, additional, Georgieff, Michael, additional, and Träger, Karl, additional

Published
2000
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26. EFFECTS OF SELECTIVE iNOS INHIBITION ON GUT AND LIVER O2EXCHANGE AND ENERGY METABOLISM DURING HYPERDYNAMIC PORCINE ENDOTOXEMIA

Author

Matjovi, Martin, Radermacher, Peter, Tugtekin, Ilyas, Stehr, Alexander, Theisen, Marc, Vogt, Josef, Wachter, Ulrich, Ploner, Franz, Georgieff, Michael, and Träger, Karl

Abstract

We have previously demonstrated that nonselective nitric oxide synthase NOS inhibition did not reverse the LPSinduced deterioration of hepatosplanchnic energy status in porcine endotoxic shock. Therefore, this study investigated the effect of selective inducible NOS iNOS inhibition using 1400W on intestinal and liver perfusion, O2kinetics, and energy metabolism during hyperdynamic porcine endotoxemia. Intravenous E. ColiLPS was continuously infused over 24 h concomitant with fluid resuscitation. After 12 h of endotoxemia, continuous intravenous infusion of 1400W was started until the end of the experiment and was titrated to maintain mean blood pressure MAP at baseline levels. Twelve, 18, and 24 h after starting LPS, we measured hepatic arterial and portal venous blood flow, ileal mucosalarterial PCO2gap, portal as well as hepatic venous lactatepyruvate ratios, and endogenous glucose production rate. Expired NO and plasma nitrate levels were assessed as a measure of NO production. 1400W decreased LPSinduced increase in expired NO and allowed for the maintenance of MAP without modification of cardiac output. Despite unchanged regional macrocirculation, 1400W prevented the progressive rise of ileal mucosalarterial PCO2gap, significantly improved the LPSinduced impairment of hepatosplanchnic redox state, and blunted the decline in liver lactate clearance. Increased glucose production rate was not influenced. Thus, the selective iNOS inhibition with 1400W prevented circulatory failure and largely attenuated otherwise progressive LPSinduced deterioration of intestinal and hepatocellular energy metabolism.

Published
2001

27. EFFECTS OF THE COMBINED THROMBOXANE RECEPTOR ANTAGONIST AND SYNTHASE INHIBITOR DTTX30 ON INTESTINAL O2EXCHANGE AND ENERGY METABOLISM DURING HYPERDYNAMIC PORCINE ENDOTOXEMIA

Author

Matejovic, Martin, Radermacher, Peter, Zülke, Carl, Vlatten, Arnim, Altherr, Jürgen, Brinkmann, Alexander, Brückner, Uwe B, Jauch, KarlWalter, Georgieff, Michael, and Träger, Karl

Abstract

Sepsis may lead to deranged thromboxaneprostacyclin ratio with consecutive organ dysfunction. Because of the suggested role of the gut in the pathogenesis of septic shock and multiple organ failure, we investigated the effects of the novel dual thromboxane synthase inhibitor and receptor antagonist DTTX30 TRASI on intestinal tissue perfusion, O2kinetics, and energy metabolism over 24 h of hyperdynamic, normotensive porcine endotoxemia. Before, 12, 18, and 24 h after starting continuous i.v. endotoxin LPS, we measured portal venous PV blood flow, intestinal oxygen extraction iO2ER, intracapillary hemoglobin O2saturation HbO2of the ileal wall, intramucosal ileal PCO2, PV lactatepyruvate LP ratio, and plasma levels of thromboxane and prostacyclin. Treatment with TRASI 0.12 mgkg i.v. bolus injection followed by an infusion of 0.29 mgkgh initiated after 12 h of LPS infusion markedly reduced the plasma thromboxane levels and attenuated the LPSinduced fall in systemic vascular resistance, resulting in hemodynamic stabilization. TRASI did not influence the LPSinduced increase in PV blood flow nor intracapillary HbO2, thus reflecting unchanged microcirculatory O2availability and decreased iO2ER, possibly because of reduced O2requirements. Nevertheless, TRASI prevented the LPSinduced increase in the PV LP ratio, attenuated the progression of the ileal mucosalarterial PCO2gap, and tended to attenuate the gradual fall of PV pH. Hence, compounds like TRASI may beneficially influence LPSrelated derangements of gut energy metabolism.

Published
2000

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