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Your search keyword '"Darvin, Maxim E."' showing total 14 results
Start Over Author "Darvin, Maxim E." Journal skin pharmacology and physiology
14 results on '"Darvin, Maxim E."'

2. In vivo skin penetration, radical protection and structural changes after topical application of a herbal oil cream compared to topical calcipotriol in mild to moderate psoriasis

Author

Lademann, Juergen, primary, Mansouri, Parvin, additional, Nahavandi, Ali, additional, Ahlers, Axel, additional, Zibakalam-Mofrad, Fatemeh, additional, Brower, Barbara, additional, Nahavandi, Maryam, additional, Feddern, Frank, additional, Darvin, Maxim E., additional, Schanzer, Sabine, additional, Richter, Heike, additional, Meinke, Martina C., additional, Rezaii, Seyed Ahmad, additional, Rohaninasab, Masoumeh, additional, Farshi, Susan, additional, Iacobelli, Massimo, additional, and Jung, Sora, additional

Published
2021
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11. Efficient Prevention Strategy against the Development of a Palmar-Plantar Erythrodysesthesia during Chemotherapy

Author

Lademann, Juergen, primary, Martschick, Anja, additional, Kluschke, Franziska, additional, Richter, Heike, additional, Fluhr, Joachim W., additional, Patzelt, Alexa, additional, Jung, Sora, additional, Chekerov, Radoslav, additional, Darvin, Maxim E., additional, Haas, Norbert, additional, Sterry, Wolfram, additional, Zastrow, Leonhard, additional, and Sehouli, Jalid, additional

Published
2013
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13. In vivo Tracking of DNA for Precise Determination of the Stratum Corneum Thickness and Superficial Microbiome Using Confocal Raman Microscopy.

Author

Ri JS, Choe SH, Schleusener J, Lademann J, Choe CS, and Darvin ME

Subjects
Adult, Female, Humans, Lipids analysis, Male, Microscopy, Confocal, Middle Aged, Young Adult, DNA analysis, Epidermis anatomy & histology, Epidermis chemistry, Epidermis microbiology, Microbiota
Abstract

The skin barrier function is mostly provided by the stratum corneum (SC), the uppermost layer of the epidermis. To noninvasively analyze the physiological properties of the skin barrier functionin vivo, it is important to determine the SC thickness. Confocal Raman microscopy (CRM) is widely used for this task. In the present in vivo study, a new method based on the determination of the DNA concentration profile using CRM is introduced for determining the SC thickness. The obtained SC thickness values are compared with those obtained using other CRM-based methods determining the water and lipid depth profiles. The obtained results show almost no significant differences in SC thickness for the utilized methods. Therefore, the results indicate that it is possible to calculate the SC thickness by using the DNA profile in the fingerprint region, which is comparable with the SC thickness calculated by the water depth profiles (ANOVA test p = 0.77) and the lipid depth profile (ANOVA test p = 0.74). This provides the possibility to measure the SC thickness by using the DNA profile, in case the water or lipid profile analyses are influenced by a topically applied formulation. The increase in DNA concentration in the superficial SC (0-2 µm) is related to the DNA presence in the microbiome of the skin, which was not present in the SC depth below 4 µm., (© 2019 S. Karger AG, Basel.)

Published
2020
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14. Efficient prevention strategy against the development of a palmar-plantar erythrodysesthesia during chemotherapy.

Author

Lademann J, Martschick A, Kluschke F, Richter H, Fluhr JW, Patzelt A, Jung S, Chekerov R, Darvin ME, Haas N, Sterry W, Zastrow L, and Sehouli J

Subjects
Aged, Angelica, Antibiotics, Antineoplastic therapeutic use, Camellia sinensis, Carcinoma drug therapy, Coffea, Doxorubicin adverse effects, Doxorubicin therapeutic use, Female, Humans, Middle Aged, Millettia, Ointments, Ovarian Neoplasms drug therapy, Polyethylene Glycols adverse effects, Polyethylene Glycols therapeutic use, Silicon Dioxide chemistry, Antibiotics, Antineoplastic adverse effects, Antioxidants therapeutic use, Doxorubicin analogs & derivatives, Hand-Foot Syndrome prevention & control, Plant Extracts therapeutic use
Abstract

Background: Pegylated liposomal doxorubicin (PLD) is a highly efficient chemotherapeutic; however, it induces dermal side effects such as palmar-plantar erythrodysesthesia (PPE) in up to 80% of cases, probably by being emitted with the sweat onto the skin surface., Aim: The aim of the present study was to examine whether a topically applied ointment containing antioxidants with a high radical protection factor is able to prevent the formation of PPE., Methods: Twenty patients suffering from ovarian carcinoma and treated with PLD were observed., Results: 60% of the patients tolerated the regular application of the cream and developed no PPE. The remaining 40% interrupted the application. Six of them developed PPE and resumed ointment application thereafter. In these cases the PPE disappeared or was strongly reduced., Conclusion: The results of the observation clearly demonstrate that topical application of the ointment is an efficient strategy against the development of PPE during chemotherapy with PLD., (Copyright © 2013 S. Karger AG, Basel.)

Published
2014
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