1. Sleep Duration and White Matter Quality in Middle-Aged Adults
- Author
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Yaffe, Kristine, Nasrallah, Ilya, Hoang, Tina D, Lauderdale, Diane S, Knutson, Kristen L, Carnethon, Mercedes R, Launer, Lenore J, Lewis, Cora E, and Sidney, Stephen
- Subjects
Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Neurosciences ,Behavioral and Social Science ,Brain Disorders ,Prevention ,Stroke ,Aging ,Clinical Research ,Sleep Research ,Aetiology ,2.3 Psychological ,social and economic factors ,Neurological ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Female ,Follow-Up Studies ,Humans ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Parietal Lobe ,Prospective Studies ,Sleep ,Sleep Deprivation ,Time Factors ,White Matter ,Young Adult ,sleep duration ,white matter integrity ,white matter hyperintensities ,midlife ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery ,Biological sciences ,Biomedical and clinical sciences - Abstract
Study objectivesSleep duration has been associated with risk of dementia and stroke, but few studies have investigated the relationship between sleep duration and brain MRI measures, particularly in middle age.MethodsIn a prospective cohort of 613 black and white adults (mean age = 45.4 years) enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study, participants reported typical sleep duration, dichotomized into moderate sleep duration (> 6 to ≤ 8 h) and short sleep duration (≤ 6 h) at baseline (2005-2006). Five years later, we obtained brain MRI markers of white matter including fractional anisotropy, mean diffusivity, and white matter hyperintensities.ResultsCompared to moderate sleepers, short sleepers had an elevated ratio of white matter hyperintensities to normal tissue in the parietal region (OR = 2.31, 95% CI: 1.47, 3.61) adjusted for age, race/sex, education, hypertension, stroke/TIA, depression, smoking status, and physical activity. White matter diffusivity was also higher, approximately a 0.2 standard deviation difference, in frontal, parietal, and temporal white matter regions, among those reporting shorter sleep duration in (P < 0.05 for all).ConclusionsShort sleep duration was associated with worse markers of white matter integrity in midlife. These mid-life differences in white matter may underlie the link between poor sleep and risk of dementia and stroke.
- Published
- 2016