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7 results on '"Mi, Lan"'

2. Self‐Enclosable External Support: Dilation‐Responsive Microshape Programing Prevents Vascular Graft Stenosis (Small 18/2021)

Author

Yi, Se Won, primary, Shin, Young Min, additional, Lee, Jung Bok, additional, Park, Ju Young, additional, Kim, Dae‐Hyun, additional, Baek, Wooyeol, additional, Yoon, Jeong‐Kee, additional, Kim, Deok Gie, additional, Shin, In Sik, additional, Kim, Chang‐Soo, additional, Kang, Mi‐Lan, additional, Yang, Jae Won, additional, and Sung, Hak‐Joon, additional

Published
2021
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3. Dilation‐Responsive Microshape Programing Prevents Vascular Graft Stenosis

Author

Yi, Se Won, primary, Shin, Young Min, additional, Lee, Jung Bok, additional, Park, Ju Young, additional, Kim, Dae‐Hyun, additional, Baek, Wooyeol, additional, Yoon, Jeong‐Kee, additional, Kim, Deok Gie, additional, Shin, In Sik, additional, Kim, Chang‐Soo, additional, Kang, Mi‐Lan, additional, Yang, Jae Won, additional, and Sung, Hak‐Joon, additional

Published
2021
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4. Anti‐Atherogenic Effect of Stem Cell Nanovesicles Targeting Disturbed Flow Sites

Author

Yoon, Jeong‐Kee, primary, Kim, Dae‐Hyun, additional, Kang, Mi‐Lan, additional, Jang, Hyeon‐Ki, additional, Park, Hyun‐Ji, additional, Lee, Jung Bok, additional, Yi, Se Won, additional, Kim, Hye‐Seon, additional, Baek, Sewoom, additional, Park, Dan Bi, additional, You, Jin, additional, Lee, Seong‐Deok, additional, Sei, Yoshitaka, additional, Ahn, Song Ih, additional, Shin, Young Min, additional, Kim, Chang Soo, additional, Bae, Sangsu, additional, Kim, YongTae, additional, and Sung, Hak‐Joon, additional

Published
2020
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5. Self‐Enclosable External Support: Dilation‐Responsive Microshape Programing Prevents Vascular Graft Stenosis (Small 18/2021)

Author

Jung Bok Lee, Se Won Yi, Young Min Shin, Hak-Joon Sung, Deok Gie Kim, In Sik Shin, Mi-Lan Kang, Jeong-Kee Yoon, Ju Young Park, Dae Hyun Kim, Jae Won Yang, Chang-Soo Kim, and Wooyeol Baek

Subjects
Biomaterials, medicine.medical_specialty, Dilation (metric space), business.industry, Internal medicine, Cardiology, Vascular graft stenosis, Medicine, General Materials Science, General Chemistry, business, Biotechnology
Published
2021

6. Dilation‐Responsive Microshape Programing Prevents Vascular Graft Stenosis

Author

Jung Bok Lee, Deok Gie Kim, Mi-Lan Kang, Se Won Yi, Hak-Joon Sung, Jeong-Kee Yoon, Chang-Soo Kim, Wooyeol Baek, In Sik Shin, Jae Won Yang, Dae Hyun Kim, Young Min Shin, and Ju Young Park

Subjects
medicine.medical_specialty, Smooth muscle cell migration, Constriction, Pathologic, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Veins, Biomaterials, Internal medicine, Adventitia, medicine, Vascular graft stenosis, Humans, General Materials Science, Vascular Diseases, Vein, business.industry, Vasa Vasorum, General Chemistry, Blood flow, 021001 nanoscience & nanotechnology, medicine.disease, Dilatation, 0104 chemical sciences, Stenosis, medicine.anatomical_structure, Vasa vasorum, cardiovascular system, Cardiology, Dilation (morphology), 0210 nano-technology, business, Biotechnology
Abstract

Shape memory materials have been successfully applied to minimally invasive implantation of medical devices. However, organ-movement-specific shape programing at a microscale level has never been demonstrated despite significant unmet needs. As vein-to-artery grafting induces vein dilation and stenosis, a polymeric self-enclosable external support (SES) is designed to wrap the vascular out-wall. Its micropores are programmed to increase sizes and interconnections upon dilation. Vessel dilation promotes venous maturation, but overdilation induces stenosis by disturbed blood flow. Therefore, the unique elastic shape-fixity of SES provides a foundation to enable a stable microscale shape transition by maintaining the vein dilation. The shape transition of micropore architecture upon dilation induces beneficial inflammation, thereby regenerating vasa vasorum and directing smooth muscle cell migration toward adventitia with the consequent muscle reinforcement of veins. This game-changer approach prevents the stenosis of vein-to-artery grafting by rescuing ischemic disorders and promoting arterial properties of veins.

Published
2021

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