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Allergic diseases are increasing all over the world, now affecting up to 40% of the population. The most frequently occurring allergic conditions include allergic rhinitis (hay fever), chronic sinusitis, atopic dermatitis, and chronic urticaria. The literature suggests that second-generation histamine 1 (H1) antihistamines are the preferred first-line therapy for most chronic allergic conditions, including allergic rhinitis and chronic urticaria. Patients taking these antihistamines report little to no adverse effects with long-term continuous treatment. Second-generation H1-antihistamines have been shown to exert an anti-inflammatory effect, and continuous administration may improve their efficacy. [ABSTRACT FROM AUTHOR]

Allergic disease decreases the daily quality of life of many people, and can increase the number of working days lost owing to sick leave. Associated symptoms with allergic disease depend on the origin of the disease, and can either be allergic, non-allergic and purulent, or can cause rhinitis as a result of a common cold. Treatment depends on the origin of the rhinitis. However, an antihistamine is indicated in most instances. Combination treatment includes sympathomimetic drugs (either local or systemic) and corticosteroid medication (when indicated, and in most instances, used locally). The article provides an overview of the nature and the management of allergic disease and the histamine 1 antihistamines. [ABSTRACT FROM AUTHOR]