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Adverse drug events (ADEs) have been found to be a major cause of morbidity and mortality in healthcare systems around the world. More than 50% of ADEs are preventable, and have been demonstrated to be the result of an incomplete medication history, prescribing or dispensing error, and the over- or underuse of prescribed pharmacotherapy. The main aim of implementing medication reconciliation in a hospital setting is to avoid ADEs, a prevalent patient safety issue. Medication reconciliation is the process of creating the most accurate list possible of all medications a patient is taking, including drug name, dosage, frequency and route, and then comparing that list against the admission, transfer, and/or discharge orders. Medication reconciliation is one of World Health Organization's High 5s initiative to improve patient safety. The implementation of the International Standard Operating Procedure for Medication Reconciliation led to a 50% reduction in medication discrepancies in developed countries. Implementing the medication reconciliation in the hospitals of South Africa may reduce medication errors. [ABSTRACT FROM AUTHOR]