1. What is the link between vitamin D and tuberculosis?
- Author
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Kibirige, D., Kiggundu, D. S., and Worodria, W.
- Subjects
VITAMIN D deficiency ,IMMUNE response ,PEPTIDE antibiotics ,CYTOKINES ,TUBERCULOSIS mortality ,TUBERCULOSIS risk factors ,GENETIC polymorphisms - Abstract
Tuberculosis is one of the leading causes of morbidity and mortality globally. Vitamin D directly influences the body's immunological response to tuberculosis by modulating the production of certain antimicrobial peptides and the release of cytokines. Vitamin D deficiency has been extensively described in patients with tuberculosis. Currently, it is a recognised risk factor for tuberculosis. Genetic polymorphisms of the vitamin D receptor may influence host susceptibility to tuberculosis and response to antituberculosis therapy. This review article explores the close association between tuberculosis and vitamin D, with the aim of forming a strong basis for further interventional and genetic studies on patients with active tuberculosis. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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