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The aim of the work is to identify a clustering structure for the 20 Italian regions according to the main variables related to COVID-19 pandemic. Data are observed over time, spanning from the last week of February 2020 to the first week of February 2021. Dealing with geographical units observed at several time occasions, the proposed fuzzy clustering model embedded both space and time information. Properly, an Exponential distance-based Fuzzy Partitioning Around Medoids algorithm with spatial penalty term has been proposed to classify the spline representation of the time trajectories. The results show that the heterogeneity among regions along with the spatial contiguity is essential to understand the spread of the pandemic and to design effective policies to mitigate the effects., (© 2021 Published by Elsevier B.V.)

The main determinants of COVID-19 spread in Italy are investigated, in this work, by means of a D-vine copula based quantile regression. The outcome is the COVID-19 cumulative infection rate registered on October 30th 2020, with reference to the 107 Italian provinces, and it is regressed on some covariates of interest accounting for medical, environmental and demographic factors. To deal with the issue of spatial autocorrelation, the D-vine copula based quantile regression also embeds a spatial autoregressive component that controls for the extent of spatial dependence. The use of vine copula enhances model flexibility accounting for non-linear relationships and tail dependencies. Moreover, the model selection procedure leads to parsimonious models providing a rank of covariates based on their explanatory power with respect to the outcome., (© 2022 Elsevier B.V. All rights reserved.)