15 results on '"Zhu, Jiaqi"'
Search Results
2. Decision-making Algorithm for the Surgical Treatment of Degenerative Lumbar Spondylolisthesis of L4/L5
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Schönnagel, Lukas, Caffard, Thomas, Zhu, Jiaqi, Tani, Soji, Camino-Willhuber, Gaston, Amini, Dominik A., Haffer, Henryk, Muellner, Maximilian, Guven, Ali E., Chiapparelli, Erika, Arzani, Artine, Amoroso, Krizia, Shue, Jennifer, Duculan, Roland, Zippelius, Timo, Sama, Andrew A., Cammisa, Frank P., Girardi, Federico P., Mancuso, Carol A., and Hughes, Alexander P.
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- 2024
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3. Understanding the Interplay Between Paraspinal Muscle Atrophy and Lumbar Endplate Degeneration: A 3-Year Longitudinal Study
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Schönnagel, Lukas, Zhu, Jiaqi, Guven, Ali E., Camino-Willhuber, Gaston, Tani, Soji, Caffard, Thomas, Haffer, Henryk, Muellner, Maximilian, Chiapparelli, Erika, Amoroso, Krizia, Arzani, Artine, Moser, Manuel, Shue, Jennifer, Tan, Ek T., Carrino, John A., Jöns, Thomas, Sama, Andrew A., Girardi, Federico P., Cammisa, Frank P., and Hughes, Alexander P.
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- 2023
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4. Decision-making Algorithm for the Surgical Treatment of Degenerative Lumbar Spondylolisthesis of L4/L5
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Schönnagel, Lukas, Caffard, Thomas, Zhu, Jiaqi, Tani, Soji, Camino-Willhuber, Gaston, Amini, Dominik A., Haffer, Henryk, Muellner, Maximilian, Guven, Ali E., Chiapparelli, Erika, Arzani, Artine, Amoroso, Krizia, Shue, Jennifer, Duculan, Roland, Zippelius, Timo, Sama, Andrew A., Cammisa, Frank P., Girardi, Federico P., Mancuso, Carol A., and Hughes, Alexander P.
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- 2023
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5. Osteosarcopenia in the Spine Beyond Bone Mineral Density: Association Between Paraspinal Muscle Impairment and Advanced Glycation Endproducts
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Haffer, Henryk, Muellner, Maximilian, Chiapparelli, Erika, Dodo, Yusuke, Zhu, Jiaqi, Han, Yi Xin, Donnelly, Eve, Tan, Ek T., Shue, Jennifer, Sama, Andrew A., Cammisa, Frank P., Girardi, Federico P., and Hughes, Alexander P.
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- 2023
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6. How much improvement in Oswestry Disability Index is Necessary to make your Patient Satisfied after Lumbar Surgery?
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Hambrecht, Jan, primary, Köhli, Paul, additional, Chiapparelli, Erika, additional, Amoroso, Krizia, additional, Zhu, Jiaqi, additional, Lan, Ranqing, additional, Guven, Ali E., additional, Evangelisti, Gisberto, additional, Burkhard, Marco D., additional, Tsuchiya, Koki, additional, Duculan, Roland, additional, Shue, Jennifer, additional, Sama, Andrew A., additional, Cammisa, Frank P., additional, Girardi, Federico P., additional, Mancuso, Carol A., additional, and Hughes, Alexander P., additional
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- 2024
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7. Association Between Cervical Sagittal Alignment and Subaxial Paraspinal Muscle Parameters
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Caffard, Thomas, primary, Arzani, Artine, additional, Verna, Bruno, additional, Tripathi, Vidushi, additional, Chiapparelli, Erika, additional, Medina, Samuel J., additional, Schönnagel, Lukas, additional, Tani, Soji, additional, Camino-Willhuber, Gaston, additional, Amoroso, Krizia, additional, Guven, Ali E., additional, Zhu, Jiaqi, additional, Tan, Ek Tsoon, additional, Carrino, John A., additional, Shue, Jennifer, additional, Awan Malik, Hassan, additional, Zippelius, Timo, additional, Dalton, David, additional, Sama, Andrew A., additional, Girardi, Federico P., additional, Cammisa, Frank P., additional, and Hughes, Alexander P., additional
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- 2023
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8. Association Between Osteoarthritis Burden and Intervertebral Disk Degeneration in Patients Undergoing Lumbar Spine Surgery for Degenerative Lumbar Spondylolisthesis
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Schönnagel, Lukas, primary, Camino-Willhuber, Gaston, additional, Braun, Sebastian, additional, Zhu, Jiaqi, additional, Tani, Soji, additional, Guven, Ali E., additional, Caffard, Thomas, additional, Chiapparelli, Erika, additional, Arzani, Artine, additional, Haffer, Henryk, additional, Muellner, Maximilian, additional, Shue, Jennifer, additional, Duculan, Roland, additional, Bendersky, Mariana, additional, Cammisa, Frank P., additional, Girardi, Federico P., additional, Sama, Andrew A., additional, Mancuso, Carol A., additional, and Hughes, Alexander P., additional
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- 2023
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9. Relationship between Lumbar Foraminal Stenosis and Multifidus Muscle Atrophy - A Retrospective Cross-Sectional Study.
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Guven AE, Schönnagel L, Chiapparelli E, Camino-Willhuber G, Zhu J, Caffard T, Arzani A, Finos K, Nathoo I, Amoroso K, Shue J, Sama AA, Cammisa FP, Girardi FP, and Hughes AP
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Study Design: Retrospective cross-sectional study., Objective: To evaluate the relationship between lumbar foraminal stenosis (LFS) and multifidus muscle atrophy., Background: The multifidus muscle is an important stabilizer of the lumbar spine. In LFS, the compression of the segmental nerve can give rise to radicular symptoms and back pain. LFS can impede function and induce atrophy of the segmentally innervated multifidus muscle., Methods: Patients with degenerative lumbar spinal conditions who underwent posterior spinal fusion for degenerative lumbar disease from December 2014 to February 2024 were analyzed. Multifidus fatty infiltration (FI) and functional cross-sectional area (fCSA) were determined at the L4 upper endplate axial level on T2- weighted MRI scans using dedicated software. Severity of LFS was assessed at all lumbar levels and sides using the Lee classification (Grade: 0 - 3). For each level, Pfirrmann and Weishaupt gradings were used to assess intervertebral disc disease (IVDD) and facet joint osteoarthritis (FJOA), respectively. Multivariable linear mixed models were run for the LFS grade of each level and side separately as the independent predictor of multifidus FI and fCSA. Each analysis was adjusted for age, sex, BMI, as well as FJOA and IVDD of the level corresponding to the LFS., Results: A total of 216 patients (50.5% female) with a median age of 61.6 years (IQR=52.0 - 69.0) and a median BMI of 28.1 kg/m2 (IQR=24.8 - 33.0) were included. Linear mixed model analysis revealed that higher multifidus FI (Estimate [Confidence interval]=1.7% [0.1 - 3.3], P=0.043) and lower fCSA (-18.6 mm2 [-34.3 - -2.6], P=0.022) were both significantly predicted by L2-L3 level LFS severity., Conclusion: The observed positive correlation between upper segment LFS and multifidus muscle atrophy points towards compromised innervation. This necessitates further research to establish the causal relationship and guide prevention efforts., Competing Interests: Declaration of conflicting interest: The Authors declare that there is no conflict of interest concerning materials or methods used in this study or the findings specified in this paper., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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10. Reasons for Revision Surgery after Cervical Disc Arthroplasty based on Medical Device Reports Maintained by the United States Food and Drug Administration.
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Altorfer FCS, Kelly MJ, Avrumova F, Zhu J, Abjornson C, and Lebl DR
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Study Design: Retrospective Database review., Objective: Analyze revisions of CDAs reported to the MAUDE database., Summary of Background Data: Cervical disc arthroplasty (CDA) has emerged as a motion-preserving alternative to anterior cervical discectomy and fusion (ACDF) for degenerative cervical disease, demonstrating comparable outcomes. Despite the availability of variable CDA designs, there is limited data on the specific complications of individual CDAs. The Drug Administration's Manufacturer and User Facility Device Experience (MAUDE) database has been used to systematically report complications associated with CDAs. However, data on specific reasons for CDA revision remains scarce. The purpose of this study is to compare common complications associated with revision for different CDAs., Methods: The MAUDE database was queried from January 2005 to September 2023, including all nine FDA-approved CDAs. The full-text reports of each complication were categorized based on whether revision surgery was performed, the complications and the type of CDA collected and compared., Results: A total of 678 revisions for nine CDAs were reported: Mobi-C (239), M6 (167), Prodisc-C (88), Prestige (60), PCM (44), Bryan (35), Secure (23), Simplify (21), and Discover (1). The top three complications associated with revision were migration (23.5%), neck pain (15.5%), and heterotopic ossification (6.6%). The most common complications per device were migration for Mobi-C (26.4%), Prodisc-C (21.3%), Prestige (24.6%), PCM (84.1%), Bryan (48.6%), Secure (30.4%), and Discover (100%). For M6, the most common complications associated with revision surgery were osteolysis (18.6%) and neck pain (18.6%), while neck pain (23.8%) was the most common for the Simplify., Conclusion: The MAUDE database highlights complications related to CDA revision in which the primary complications consistently include implant migration, neck pain, and heterotopic ossification ,varying in their rerelvance depending on the CDA., Competing Interests: Disclosure: The authors do not have a conflict of interest in this study. FCSA, MJK, FA, and JZ have no industry relations. CA is a Consultant on the advisory Board for Camber Spine Tech, a Consultant for Centinel Spine, Inc., is in the Advisory Board, and has an Ownership Interest in Orthobond Corporation and Surgalign. DRL is a Consultant and on the Advisory Board for Choice Spine. DRL is a consultant for Depuy Synthes. DRL has Ownership Interest from Woven Orthopedic Technologies, Vestia Ventures MiRus Investment LLC HS2, LLC and ISPH II, LLC. DRL has Research Support from Medtronic Sofamor Danek USA, Inc. DRL has Royalties from Nuvasive, Inc. DRL is on the Advisory Board and has Ownership Interest from Remedy Logic. DRL is a Consultant and has Royalties from Stryker. DRL is a Consultant and has Ownership Interest from Viseon, Inc., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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11. The Reciprocal Relationship Between Lumbar Intervertebral Disk Degeneration and the MRI-based Vertebral Bone Quality Score.
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Moser M, Adl Amini D, Albertini Sanchez L, Oezel L, Zhu J, Nevzati E, Carrino JA, Shue J, Sama AA, Cammisa FP, Girardi FP, and Hughes AP
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- Humans, Female, Male, Middle Aged, Retrospective Studies, Aged, Longitudinal Studies, Bone Density physiology, Low Back Pain diagnostic imaging, Lumbar Vertebrae diagnostic imaging, Intervertebral Disc Degeneration diagnostic imaging, Magnetic Resonance Imaging methods
- Abstract
Study Design: Retrospective longitudinal study., Objective: To investigate the association between lumbar intervertebral disk degeneration (DD) and the vertebral bone quality (VBQ) score., Background: The VBQ score that is based on magnetic resonance imaging has been proposed as a measure of lumbar spine bone quality and is a significant predictor of healthy versus osteoporotic bone. However, the role of segmental contributing factors on VBQ is unknown., Methods: Nonsurgical patients who underwent repeated lumbar magnetic resonance imaging scans, at least three years apart primarily for low back pain were retrospectively included. VBQ was assessed as previously described. DD was assessed using the Pfirrmann grading (PFG) scale. PFG grades were summarized as PFG L1-4 for the upper three lumbar disk levels, as PFG L4-S1 for the lower two lumbar disc levels, and as PFG L1-S1 for all lumbar disc levels. Multivariable linear mixed models were used with adjustments for age, sex, race, body mass index, and the clustering of repeated measurements., Results: A total of 350 patients (54.6% female, 85.4% White) were included in the final analysis, with a median age at baseline of 60.1 years and a body mass index of 25.8 kg/m 2 . VBQ significantly increased from 2.28 at baseline to 2.36 at follow-up ( P = 0.001). In the unadjusted analysis, a significant positive correlation was found between PFG L1-4 , PFG L1-S1 , and VBQ at baseline ( P < 0.05) that increased over time ( P < 0.005). In the adjusted multivariable analysis, PFG L1-4 ( β = -0.0195; P = 0.021), PFG L4-S1 ( β = -0.0310; P = 0.007), and PFG L1-S1 ( β = -0.0160; P = 0.012) were independently and negatively associated with VBQ., Conclusions: More advanced and long-lasting DD is associated with lower VBQ indicating less bone marrow fat content and potentially stronger bone. VBQ score as a marker of bone quality seems affected by DD., Competing Interests: J.A.C. reports consulting fees from Pfizer, Inc., Eli-Lilly, Globus Medical Inc., Regeneron, and AstraZeneca; membership of the scientific advisory board of Carestream, Image Analysis Group, and Image Biopsy Lab; A.A.S. reports royalties from Ortho Development, Corp.; private investments for Vestia Ventures MiRUS Investment, LLC, ISPH II, LLC, ISPH 3, LLC, and VBros Venture Partners X Centinel Spine; consulting fees from Clariance, Inc., Kuros Biosciences AG, and Medical Device Business Service, Inc.; speaking and teaching arrangements of DePuy Synthes Products, Inc.; membership of the scientific advisory board of Clariance Inc., and Kuros Biosciences AG; and trips/travel of Medical Device Business research support from Spinal Kinetics Inc., outside the submitted work. F.P.C. reports royalties from NuVasive, Inc.; private investments for 4WEB Medical/4WEB, Inc., Bonovo Orthopedics, Inc., Healthpoint Capital Partners, LP, ISPH II, LLC, ISPH 3 Holdings, LLC, Ivy Healthcare Capital Partners, LLC, Medical Device Partners II, LLC, Medical Device Partners III, LLC, Orthobond Corporation, Spine Biopharma, LLC, Synexis, LLC, Tissue Differentiation Intelligence, LLC, VBVP VI, LLC, VBVP X, LLC (Centinel) and Woven Orthopedics Technologies; consulting fees from 4WEB Medical/4WEB Inc., DePuy Synthes Spine, NuVasive Inc., Spine Biopharma, LLC, and Synexis, LLC; membership of scientific advisory board/other offices of Healthpoint Capital Partners, LP, Medical Device Partners III, LLC, Orthobond Corporation, Spine Biopharma, LLC, Synexis, LLC, and Woven Orthopedic Technologies; and research support from 4WEB Medical/4WEB Inc., Mallinckrodt Pharmaceuticals, Camber Spine, and Centinel Spine, outside the submitted work. Girardi reports royalties from Lanx Inc., and Ortho Development Corp.; private investments for Centinel Spine, and BCMID; stock ownership of Healthpoint Capital Partners, LP; and consulting fees from NuVasive, Inc., and DePuy Synthes Spine, outside the submitted work. Hughes reports research support from NuVasive Inc. and Kuros Biosciences AG; and fellowship support from NuVasive Inc. and Kuros Biosciences AG, outside the submitted work. The remaining authors report no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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12. Abdominal Aortic Calcification is Associated with Degeneration of The Paraspinal Muscles - A Retrospective cross-sectional Study.
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Schömig F, Schönnagel L, Zhu J, Suwalski P, Köhli P, Caffard T, Guven AE, Chiapparelli E, Arzani A, Amoroso K, Shue J, Sama AA, Cammisa FP, Girardi FP, and Hughes AP
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Study Design: Retrospective cohort study., Objective: To analyze the relationship of abdominal aortic calcification (AAC) and a reduction in the cross-sectional area (CSA) and the fatty infiltration (FI) of the paravertebral muscles in patients undergoing lumbar fusion surgery., Background: Both AAC and paraspinal muscle degeneration have been shown to be associated with poorer outcomes after surgical treatment of degenerative diseases of the lumbar spine. However, there is a lack of data on the association between AAC and paraspinal muscle changes in patients undergoing spine surgery., Methods: We retrospectively analyzed patients undergoing lumbar fusion for degenerative spinal pathologies. Muscular and spinal degeneration were measured on magnetic resonance imaging (MRI). AAC was classified on lateral lumbar radiographs. The association of AAC and paraspinal muscle composition was assessed by a multivariate regression analysis adjusted for age, sex, body mass index (BMI), comorbidities, and lumbar degeneration., Results: A total of 301 patients was included. Patients with AAC showed significantly higher degrees of intervertebral disc and facet joint degeneration as well as higher total endplate scores at the L3/4 level. The univariable regression analysis showed a significant positive correlation between the degree of AAC and the FI of the erector spinae (b=0.530, P<0.001) and multifidus (b=0.730, P<0.001). The multivariable regression analysis showed a significant positive correlation between the degree of AAC and the FI of the erector spinae (b=0.270, P=0.006) and a significant negative correlation between the degree of AAC and the CSA of the psoas muscle (b=-0.260, P=0.003)., Conclusion: This study demonstrates a significant and independent association between AAC and degeneration of the erector spinae and the psoas muscles in patients undergoing lumbar fusion. As both AAC and degeneration of paraspinal muscles impact postoperative outcomes negatively, preoperative assessment of AAC may aid in identifying patients at higher risk after lumbar surgery., Competing Interests: Declaration of Conflicting Interest: The Authors declare that there is no conflict of interest concerning materials or methods used in this study or the findings specified in this paper., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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13. Association Between Cervical Sagittal Alignment and Subaxial Paraspinal Muscle Parameters.
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Caffard T, Arzani A, Verna B, Tripathi V, Chiapparelli E, Medina SJ, Schönnagel L, Tani S, Camino-Willhuber G, Amoroso K, Guven AE, Zhu J, Tan ET, Carrino JA, Shue J, Awan Malik H, Zippelius T, Dalton D, Sama AA, Girardi FP, Cammisa FP, and Hughes AP
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- Humans, Paraspinal Muscles diagnostic imaging, Neck, Neck Muscles, Retrospective Studies, Cervical Vertebrae diagnostic imaging, Cervical Vertebrae surgery, Lordosis diagnostic imaging, Lordosis surgery
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Study Design: Retrospective review of prospectively collected data., Objective: The authors aim to investigate the association between muscle functional group characteristics and sagittal alignment parameters in patients undergoing anterior cervical discectomy and fusion., Summary of Background Data: The relationship between the morphology of cervical paraspinal muscles and sagittal alignment is not well understood., Materials and Methods: Patients with preoperative cervical magnetic resonance imaging and cervical spine lateral radiographs in standing position who underwent anterior cervical discectomy and fusion between 2015 and 2018 were reviewed. Radiographic alignment parameters included C2 to 7 lordosis, C2 to 7 sagittal vertical axis (SVA), C2 slope, neck tilt, T1 slope, and thoracic inlet angle. Muscles from C3 to C7 were categorized into four functional groups: sternocleidomastoid group, anterior group, posteromedial group, and posterolateral group (PL). A custom-written Matlab software was used to assess the functional cross-sectional area (fCSA) and percent fat infiltration (FI) for all groups. Multivariable linear regression analyses were conducted and adjusted for age, sex, and body mass index., Results: A total of 172 patients were included. Regression analyses demonstrated that a greater C2 to 7 SVA was significantly associated with a greater FI of the anterior group from C3 to C5 and with a higher fCSA of the PL group at C3 to C4, and C6 to 7. A larger C2 slope was significantly correlated with a greater FI of the anterior group at C3 to C4 and a higher fCSA of the PL group from C3 to C5., Conclusion: This work proposes new insights into the complex interaction between sagittal alignment and cervical paraspinal muscles by emphasizing the importance of these muscles in sagittal alignment. The authors hypothesize that with cervical degeneration, the stabilizing function of the anterior muscles decreases, which may result in an increase in the compensatory mechanism of the PL muscles. Consequently, there may be a corresponding increase in the C2 to C7 SVA and a larger C2 slope., Competing Interests: S.A.A. reports royalties from Ortho Development, Corp.; private investments for Vestia Ventures MiRUS Investment, LLC, IVY II, LLC, ISPH II, LLC, ISPH 3, LLC, HS2, LLC, HSS ASC Development Network, LLC, and Centinel Spine (Vbros Venture Partners V); consulting fee from Depuy Synthes Products Inc., Clariance Inc., Kuros Biosciences AG, Ortho Development Corp., Medical Device Business Service Inc.; speaking and teaching arrangements of DePuy Synthes Products Inc.; membership of scientific advisory board of Depuy Synthes Products Inc., Clariance Inc., and Kuros Biosciences AG; Medical Device Business Service Inc. and trips/travel of Medical Device Business; research support from Spinal Kinetics Inc., outside the submitted work. C.F.P. reports royalties from NuVasive Inc. Accelus; ownership interest for 4WEB Medical/4WEB Inc.; Healthpoint Capital Partners, LP; ISPH II LLC; ISPH 3 Holdings LLC; Ivy Healthcare Capital Partners LLC; Medical Device Partners II LLC; Medical Device Partners III LLC; Orthobond Corporation; Spine Biopharma LLC; Tissue Differentiation Intelligence LLC; VBVP VI LLC; VBVP X LLC; Woven Orthopedics Technologies; consulting fees from 4WEB Medical/4WEB Inc., DePuy Synthes, NuVasive Inc., Spine Biopharma LLC, and Synexis LLC, Accelus; membership of scientific advisory board/other office of Healthpoint Capital Partners, Medical Device Partners II LLC, Orthobond Corporation, Spine Biopharma LLC, and Woven Orthopedic Technologies; and research support from 4WEB Medical/4WEB Inc., Mallinckrodt Pharmaceuticals, Camber Spine, and Centinel Spine, outside the submitted work. G.F.P. reports royalties from Lanx Inc., and Ortho Development Corp.; private investments for BCIMD; and stock ownership of Healthpoint Capital Partners, LP, outside the submitted work. H.A.P. reports research support from Kuros Biosciences AG and Expanding Innovations Inc.; and fellowship support from NuVasive Inc. and Kuros Biosciences BV, outside the submitted work. The remaining authors report no conflicts of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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14. Association Between Severity of Cervical Central Spinal Stenosis and Paraspinal Muscle Parameters in Patients Undergoing Anterior Cervical Discectomy and Fusion.
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Caffard T, Arzani A, Verna B, Tripathi V, Chiapparelli E, Schönnagel L, Zhu J, Medina SJ, Tani S, Camino-Willhuber G, Guven AE, Amoroso K, Tan ET, Carrino JA, Shue J, Kelly MJ, Burkhard MD, Awan Malik H, Zippelius T, Dalton D, Sama AA, Girardi FP, Cammisa FP, and Hughes AP
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Study Design: Retrospective study., Objective: The aim of this study was to evaluate the association between severity and level of cervical central stenosis (CCS) and the fat infiltration (FI) of the cervical multifidus/rotatores (MR) at each subaxial levels., Summary of Background Data: The relationship between cervical musculature morphology and the severity of CCS is poorly understood., Methods: Patients with preoperative cervical magnetic resonance imaging (MRI) who underwent anterior cervical discectomy and fusion (ACDF) were reviewed. The cervical MR were segmented from C3 to C7 and the percent FI was measured using a custom-written Matlab software. The severity of the CCS at each subaxial level was assessed using a previously published classification. Grade 3, representing a loss of cerebrospinal fluid space and deformation of the spinal cord > 25%, was set as the reference and compared to the other gradings. Multivariable linear regression analyses were conducted and adjusted for age, sex, and body mass index., Results: 156 consecutive patients were recruited. A spinal cord compression at a certain level was significantly associated with a greater FI of the MR below that level. After adjustment for the above-mentioned confounders, our results showed that spinal cord compression at C3/4 and C4/5 was significantly associated with greater FI of the MR from C3 to C6 and C5 to C7, respectively. A spinal cord compression at C5/6 or C6/7 was significantly associated with greater FI of the MR at C7., Conclusion: Our results demonstrated significant correlations between the severity of CCS and a greater FI of the MR. Moreover, significant level-specific correlations were found. A significant increase in FI of the MR at the levels below the stenosis was observed in patients presenting with spinal cord compression. Given the segmental innervation of the MR, the increased FI might be attributed to neurogenic atrophy., Level of Evidence: 3., Competing Interests: The authors report no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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15. Association Between Osteoarthritis Burden and Intervertebral Disk Degeneration in Patients Undergoing Lumbar Spine Surgery for Degenerative Lumbar Spondylolisthesis.
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Schönnagel L, Camino-Willhuber G, Braun S, Zhu J, Tani S, Guven AE, Caffard T, Chiapparelli E, Arzani A, Haffer H, Muellner M, Shue J, Duculan R, Bendersky M, Cammisa FP, Girardi FP, Sama AA, Mancuso CA, and Hughes AP
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- Humans, Female, Male, Retrospective Studies, Lumbar Vertebrae surgery, Lumbar Vertebrae pathology, Intervertebral Disc Degeneration epidemiology, Intervertebral Disc Degeneration surgery, Intervertebral Disc Degeneration pathology, Spondylolisthesis surgery, Spondylolisthesis pathology, Osteoarthritis, Hip pathology, Osteoarthritis, Knee pathology
- Abstract
Study Design: A retrospective analysis of prospectively collected data., Objective: To assess the association between intervertebral disk degeneration and hip and knee osteoarthritis (OA) in patients with degenerative lumbar spondylolisthesis., Background: The co-occurrence of hip OA and degenerative spinal pathologies was first described as the "hip-spine syndrome" and has also been observed in knee OA. It remains unclear whether both pathologies share an underlying connection beyond demographic factors., Materials and Methods: Intervertebral disk degeneration was classified by the Pfirrmann Classification and intervertebral vacuum phenomenon. Intervertebral vacuum phenomenon was classified into mild (1 point), moderate (2 points), and severe (3 points) at each level and combined into a lumbar vacuum score (0-15 points). Similarly, a lumbar Pfirrmann grade was calculated (5-25 points). Patients with previous hip or knee replacement surgery were classified as having an OA burden. We used multivariable regression to assess the association between OA and disk degeneration, adjusted for age, body mass index, and sex., Results: A total of 246 patients (58.9% female) were included in the final analysis. Of these, 22.3% had OA burden. The multivariable linear regression showed an independent association between OA burden and lumbar vacuum (β = 2.1, P <0.001) and Pfirrmann grade (β = 2.6, P <0.001). Representing a 2.1 points higher lumbar vacuum and 2.6 points higher lumbar Pfirrmann grade after accounting for demographic differences., Conclusions: Our study showed that OA burden was independently associated with the severity of the intervertebral disk degeneration of the lumbar spine. These findings give further weight to a shared pathology of OA of large joints and degenerative processes of the lumbar spine., Level of Evidence: 3., Competing Interests: A.A.S. reports royalties from Ortho Development, Corp.; private investments for Vestia Ventures MiRUS Investment, LLC, IVY II, LLC, ISPH II, LLC, ISPH 3, LLC, HS2, LLC, HSS ASC Development Network, LLC, and Centinel Spine (Vbros Venture Partners V); consulting fee from Depuy Synthes Products Inc., Clariance Inc., Kuros Biosciences AG, Ortho Development Corp., Medical Device Business Service Inc.; speaking and teaching arrangements of DePuy Synthes Products Inc.; membership of scientific advisory board of Depuy Synthes Products Inc., Clariance Inc., and Kuros Biosciences AG; Medical Device Business Service Inc. and trips/travel of Medical Device Business; research support from Spinal Kinetics Inc., outside the submitted work. Dr. F.P.C. reports royalties from NuVasive Inc. Accelus; ownership interest for 4WEB Medical/4WEB Inc.; Healthpoint Capital Partners, LP; ISPH II, LLC; ISPH 3 Holdings, LLC; Ivy Healthcare Capital Partners, LLC; Medical Device Partners II, LLC; Medical Device Partners III, LLC; Orthobond Corporation; Spine Biopharma, LLC; Tissue Differentiation Intelligence, LLC; VBVP VI, LLC; VBVP X, LLC; Woven Orthopedics Technologies; consulting fees from 4WEB Medical/4WEB Inc., DePuy Synthes, NuVasive Inc., Spine Biopharma, LLC, and Synexis, LLC, Accelus; membership of scientific advisory board/other office of Healthpoint Capital Partners, Medical Device Partners II, LLC, Orthobond Corporation, Spine Biopharma, LLC, and Woven Orthopedic Technologies; and research support from 4WEB Medical/4WEB, Inc., Mallinckrodt Pharmaceuticals, Camber Spine, and Centinel Spine, outside the submitted work. F.P.G. reports royalties from Lanx Inc., and Ortho Development Corp.; private investments for BCIMD; and stock ownership of Healthpoint Capital Partners, LP, outside the submitted work. Hughes reports research support from Kuros Biosciences AG and fellowship support from NuVasive Inc. and Kuros Biosciences BV, outside the submitted work. The remaining authors report no conflicts of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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