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Background: Exposure to increased mechanical loading during physical training can lead to increased tendon stiffness. However, the loading regimen that maximises tendon adaptation and the extent to which adaptation is driven by changes in tendon material properties or tendon geometry is not fully understood., Objective: To determine (1) the effect of mechanical loading on tendon stiffness, modulus and cross-sectional area (CSA); (2) whether adaptations in stiffness are driven primarily by changes in CSA or modulus; (3) the effect of training type and associated loading parameters (relative intensity; localised strain, load duration, load volume and contraction mode) on stiffness, modulus or CSA; and (4) whether the magnitude of adaptation in tendon properties differs between age groups., Methods: Five databases (PubMed, Scopus, CINAHL, SPORTDiscus, EMBASE) were searched for studies detailing load-induced adaptations in tendon morphological, material or mechanical properties. Standardised mean differences (SMDs) with 95% confidence intervals (CIs) were calculated and data were pooled using a random effects model to estimate variance. Meta regression was used to examine the moderating effects of changes in tendon CSA and modulus on tendon stiffness., Results: Sixty-one articles met the inclusion criteria. The total number of participants in the included studies was 763. The Achilles tendon (33 studies) and the patella tendon (24 studies) were the most commonly studied regions. Resistance training was the main type of intervention (49 studies). Mechanical loading produced moderate increases in stiffness (standardised mean difference (SMD) 0.74; 95% confidence interval (CI) 0.62-0.86), large increases in modulus (SMD 0.82; 95% CI 0.58-1.07), and small increases in CSA (SMD 0.22; 95% CI 0.12-0.33). Meta-regression revealed that the main moderator of increased stiffness was modulus. Resistance training interventions induced greater increases in modulus than other training types (SMD 0.90; 95% CI 0.65-1.15) and higher strain resistance training protocols induced greater increases in modulus (SMD 0.82; 95% CI 0.44-1.20; p = 0.009) and stiffness (SMD 1.04; 95% CI 0.65-1.43; p = 0.007) than low-strain protocols. The magnitude of stiffness and modulus differences were greater in adult participants., Conclusions: Mechanical loading leads to positive adaptation in lower limb tendon stiffness, modulus and CSA. Studies to date indicate that the main mechanism of increased tendon stiffness due to physical training is increased tendon modulus, and that resistance training performed at high compared to low localised tendon strains is associated with the greatest positive tendon adaptation. PROSPERO registration no.: CRD42019141299., (© 2022. The Author(s).)

Background: Interventions utilising the Nordic hamstring exercise (NHE) have resulted in reductions in the incidence of hamstring strain injury (HSI). Subsequently, quantifying eccentric knee flexor strength during performance of the NHE to identify an association with the occurrence of future HSI has become increasingly common; however, the data to date are equivocal., Objective: To systematically review the association between pre-season eccentric knee flexor strength quantified during performance of the NHE and the occurrence of future HSI., Design: Systematic review and meta-analysis., Data Sources: CINAHL, Cochrane Library, Medline Complete, Embase, Web of Science and SPORTDiscus databases were searched from January 2013 to January 10, 2020., Eligibility Criteria for Selecting Studies: Prospective cohort studies which assessed the association between pre-season eccentric knee flexor strength quantified during performance of the NHE and the occurrence of future HSI., Methods: Following database search, article retrieval and title and abstract screening, articles were assessed for eligibility against pre-defined criteria then assessed for risk of bias. Meta-analysis was used to pool data across studies, with meta-regression utilised where possible., Results: A total of six articles were included in the meta-analysis, encompassing 1100 participants. Comparison of eccentric knee flexor strength during performance of the NHE in 156 injured participants and the 944 uninjured participants revealed no significant differences, regardless of whether strength was expressed as absolute (N), relative to body mass (N kg -1 ) or between-limb asymmetry (%). Meta-regression analysis revealed that the observed effect sizes were generally not moderated by age, mass, height, strength, or sport played., Conclusion: Eccentric knee flexor strength quantified during performance of the NHE during pre-season provides limited information about the occurrence of a future HSI., (© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Background: Inertial measurement units (IMUs) are used for running gait analysis in a variety of sports. These sensors have been attached at various locations to capture stride data. However, it is unclear if different placement sites affect the derived outcome measures., Objective: The aim of this systematic review and meta-analysis was to investigate the impact of placement on the validity and reliability of IMU-derived measures of running gait., Methods: Online databases SPORTDiscus with Full Text, CINAHL Complete, MEDLINE (EBSCOhost), EMBASE (Ovid) and Scopus were searched from the earliest record to 6 August 2020. Articles were included if they (1) used an IMU during running (2) reported spatiotemporal variables, peak ground reaction force (GRF) or vertical stiffness and (3) assessed validity or reliability. Meta-analyses were performed for a pooled validity estimate when (1) studies reported means and standard deviation for variables derived from the IMU and criterion (2) used the same IMU placement and (3) determined validity at a comparable running velocity (≤ 1 m·s -1 difference)., Results: Thirty-nine articles were included, where placement varied between the foot, tibia, hip, sacrum, lumbar spine (LS), torso and thoracic spine (TS). Initial contact, toe-off, contact time (CT), flight time (FT), step time, stride time, swing time, step frequency (SF), step length (SL), stride length, peak vertical and resultant GRF and vertical stiffness were analysed. Four variables (CT, FT, SF and SL) were meta-analysed, where CT was compared between the foot, tibia and LS placements and SF was compared between foot and LS. Foot placement data were meta-analysed for FT and SL. All data are the mean difference (MD [95%CI]). No significant difference was observed for any site compared to the criterion for CT (foot: - 11.47 ms [- 45.68, 22.74], p = 0.43; tibia: 22.34 ms [- 18.59, 63.27], p = 0.18; LS: - 48.74 ms [- 120.33, 22.85], p = 0.12), FT (foot: 11.93 ms [- 8.88, 32.74], p = 0.13), SF (foot: 0.45 step·min -1 [- 1.75, 2.66], p = 0.47; LS: - 3.45 step·min -1 [- 16.28, 9.39], p = 0.37) and SL (foot: 0.21 cm [- 1.76, 2.18], p = 0.69). Reliable derivations of CT (coefficient of variation [CV] < 9.9%), FT (CV < 11.6%) and SF (CV < 4.4%) were shown using foot- and LS-worn IMUs, while the CV was < 7.8% for foot-determined stride time, SL and stride length. Vertical GRF was reliable from the LS (CV = 4.2%) and TS (CV = 3.3%) using a spring-mass model, while vertical stiffness was moderately (r = 0.66) and nearly perfectly (r = 0.98) correlated with criterion measures from the TS., Conclusion: Placement of IMUs on the foot, tibia and LS is suitable to derive valid and reliable stride data, suggesting measurement site may not be a critical factor. However, evidence regarding the ability to accurately detect stride events from the TS is unclear and this warrants further investigation.

Background: Anterior cruciate ligament (ACL) injury is known to have a number of deleterious effects on lower limb muscle function. Alterations in muscle size are one such effect that have implications towards reductions in strength and functioning of the lower limbs. However, a comprehensive analysis of alterations in muscle size has yet to be undertaken., Objective: To systematically review the evidence investigating lower limb muscle size in ACL injured limbs., Design: Systematic review DATA SOURCES: Database searches of Medline, SPORTDiscus, Embase, Cinahl and Web of Science as well as citation tracking and manual reference list searching., Eligibility Criteria for Selecting Studies: Individuals with ACL deficient or reconstructed limbs with an assessment of lower limb muscle size and control limb data (contralateral or uninjured control group) METHODS: Risk of bias assessment was completed on included studies. Data were extracted and where possible meta-analyses performed. Best evidence synthesis was also undertaken., Results: 49 articles were included in this review, with 37 articles included in the meta-analyses. 66 separate meta-analyses were performed using various measures of lower limb muscle size. Across all measures, ACL deficient limbs showed lesser quadriceps femoris muscle size (d range = - 0.35 to - 0.40), whereas ACL reconstructed limbs showed lesser muscle size in the quadriceps femoris (d range = - 0.41 to - 0.69), vastus medialis (d = - 0.25), vastus lateralis (d = - 0.31), hamstrings (d = - 0.28), semitendinosus (d range = - 1.02 to - 1.14) and gracilis (d range = - 0.78 to - 0.99) when compared to uninjured limbs., Conclusion: This review highlights the effect ACL injury has on lower limb muscle size. Regardless of whether an individual chooses a conservative or surgical approach, the quadriceps of the injured limb appear to have lesser muscle size compared to an uninjured limb. When undertaking reconstructive surgery with a semitendinosus/gracilis tendon graft, the harvested muscle shows lesser muscle size compared to the uninjured limb.