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The authors provide information on the need to develop a reference material (RM) of the southern middle loamy black soil certifiedfor fertility indicators. The information about the stages of RM development is described: selection and preparation of soil material in the field; procedure of averaging soil material.In the determination of the RM metrological characteristics, the heterogeneity and stability characteristics of the RM are evaluated.The authors demonstrated the results of the RM certification for agrochemical indicators. The correctness of these results is confirmed by the results obtained in twenty-three accredited laboratories.The developed RM is registered in the State Register of the Approved Types of Certified Reference Materials under the number GSO 11369-2019-the RMfor composition (of agrochemical indicators) of the southern middle loamy black soil (SACHyuzhP-02).The RM is intended for metrological support of agroecological monitoring of agroindustrial complex laboratories.

This paper is aimed at analysing the current state and prospects of metrological support and standardisation in the field of thermal analysis in Russia. Main characteristics of reference materials used for testing, graduating, calibrating, and verifying thermal analysis instruments are described.

Human immunoglobulin and human albumin products can negatively affect patients’ health. The residual content of haemagglutinins, anti-D antibodies, prekallikrein activator, as well as the level of anticomplementary activity, are controlled during both production and testing for compliance with normative documentation. Methods for their quantitative evaluation are based on the effects of erythrocytes hemolysis or agglutination and on the amidolytic product properties of cascade reactions. These methods require the obligatory use of reference materials (RMs). The development of RMs, acting as the carrier of the quantitative characteristics of the human immunoglobulins and human albumin impurities, is fraught with the difficulty of selecting a candidate, substantiating the certification methodology, and determining the relevant characteristics. In this research, we used human immunoglobulin solutions with normalized haemagglutinin content, anti-D antibodies or anti-complementary activity in a different range, whose quality was studied using haemagglutination and chromogenic methods, and the complement fixation test. Methodological approaches to the RM development and certification were justified using system analysis and forensic audit methods. The results demonstrate the necessity of using RMs to assess the stability of analytical work by applying anti-complementary activity determination, haemagglutinin content or anti-Dantibody methods. It is established that RMs allow the quantitative content of haemagglutinins, anti-D antibodies and prekallikrein activator to be established. The value of the CRM characteristics should be approximated to the qualitative composition of these impurities in the analysed products, but in amounts not detectable (to produce negative RM components) or exceeding permissible maxima (to produce positive RM components).

Introduction. The article presents an approach to the development of interlaboratory comparison test samples and respective reference materials for use in the metrological assurance of measurements of hazardous substances in the ambient air. Materials and methods. Solid and liquid sorbents, as well as air filters were used in the experiments. Measurement methods comprised photometry, atomic absorption spectrometry, inductively coupled plasma atomic emission spectrometry. Results. An optimized algorithm for developing multi-purpose test samples that can be used for the metrological assurance of a large number of methods for analysing ambient air is presented. Discussion and conclusions. The described approach has been used to develop test samples for laboratory proficiency testing and respective reference materials, which can be used in the certification of procedures for analysing ambient air quality, calibration of measurement instruments, as well as in the internal and external quality control of results obtained during ambient air quality measurements.

The first part of the article presents the history of creating quantitative NMR analyzers of oil content and humidity of oil crop seeds and their by-products. The developed NMR analyzers differ from similar devices in the availability of metrological support (reference materials (RMs) of approved type) and an extended range of moisture measurement (5–20)%. The main metrological characteristics of the developed NMR analyzer are given. The second part of the article deals with problems solved in the process of carrying out the scientific research work on the development of metrological support for quantitative NMR analyzers. Based on the tasks set, the most optimal substances imitating oil and water components contained in the oil crops and their by-products were selected. The imitation substances in question provide long-term stability of the developed RMs, erewhile being chemically inert to each other, environmentally safe? and allowing an imitation of oil and water in oil crops and their by-products. Organosilicon fluids with (35–40) ms and (95–130) spin-spin relaxation times of protons ms are proposed as an oil imitator. To imitate water, a one-component self-vulcanizing organosilicon compound, which is applied to paper strips with a thin coat, is used in the developed type-approved RMs. In conclusion, the article presents perspective directions of developing RMs of mass fraction imitators of typical fatty acids in the oil of oil crops (sunflower, linseed, and rapeseed).

Elative to 90th Anniversary of the Rosstandart's formation we should mention about a Rosstandart's key role in start-up and activity development of the Russian State Service of Reference Materials for Composition and Properties of Substances and Materials (GSSO). This article presents the main stages of GSSO's development during USSR and the Russian Federation. The activity beginning in the field of reference materials (RMs) within GSSO dates from 1969. At that date USSR Gosstandart (nowadays Rosstandart of the Russian Federation) assumed the coordination of the work in this field. USSR Gosstandart defined the key responsibilities of GSSO: meeting the Russian needs in RMs, developing the necessary normative documents in the field of development, production and use of RMs, international cooperation in RMs, data base organization and management within the country. During the GSSO activity (as of2015) 11280 types of RMs were developed and listed on the State register of approved RM types, 1424 interstate RMs produced within the Russian Federation and 77 COOMET RMs were developed, 85 documents (basic, guidance as well as special documents designed for different field of use) were developed including 6 documents within International Organization of Legal Metrology (OIML), 12 documents for Countries of the Council of Mutual Economic Assistance (CMEA) (used to be valid till 1992), 21 interstate normative documents and 8 COOMET documents. During the last five years within the documentation development the major task was the harmonization GSSO's documents with the international documents to form the conditions for RMs development according to international requirements as well as to receive recognition of Russian RMs in the market. In the coming years the RMs harmonization should be assured by the accreditation of RMs producers in the Russian Federation and the procedure of type approval in accordance with the D 18 IOML document. The RMs development programs organized by the Federal executive authorities will be helpful to increase the RMs quantity as required in the Russian Federation.

Since 1960s UNIIM performs research in the field of needs in reference materials of composition and properties of substances and materials (RM) as well as develops it. During the research UNIIM has developed 757 types of RMs for metrological measurement assurance of factors of composition and properties of substance and materials for test laboratories of chemical, pharmaceutical, fuel, food industry, agriculture, metallurgy and ecological monitoring laboratories. List ofRMs enlarges thanks to development of UNIIM standards and transmission measurement facility from State standards of units. Taking into account the actual requirements in the field of measurements, the UNIIM's key destination is to assure the accuracy and the metrological traceability of measurements. The present-day system of RMs to be developed in UNIIM includes RMs of composition of inorganic and organic compounds and their solutions, fuels, stable isotopic materials, water, grounds, food products, biomaterials, nanomaterials, metals, alloys and other materials offerrous and non-ferrous industry, RMs of properties (thermodynamic, magnetic, physical-chemical, technical) of substances and materials. The present article considers history of RMs list development which were created by UNIIM and the strategy of this direction.

The article deals with the development of the branch for the reference materials production in the Joint Stock Company "The Gulidov Krasnoyarsk Non-Ferrous Metals Plant" (JSC "Krastsvetmet"). Here the most important workings for reference materials including the work for the London precious metal exchange, current and future works are stated.

Trends in development of reference materials (RMs) in Russia, in particular in the regulation and standardization, are described. As of December- 2015, Fifteen statutory and regulatory acts are valid in Russia in that field. The main principles of these acts to be harmonized with international requirements are discussed. Four interstate standards (for CIS country) based on ISO Guide 30, ISO Guide 31, ISO Guide 34, ISO Guide 35 are developed and issued in 2016 to harmonize activities in the RMfield. The main trend in the national and interstate standardization in the RM field is the harmonization with international RM documents (OIML, ISO). In 2015 190 new approved pattern certified reference materials (CRMs) of composition and properties of substances and materials were developed in Russia. The majority of new patterns of CRMs were developed for metallurgical, oil producing, refining and gas enterprises. Also CRM development for clinical diagnosis, pharmaceutics, ecological monitoring and production safety are still requested.. Development of CRMs based on the principles of private-state partnership is growing slowly.

The article describes the chronology of development of the system of reference materials in the nuclear industry of the Russian Federation. The basic documents used in the sphere of nuclear energy are described. The nomenclature of reference materials and feature of their application in the "Rosatom" is given. The prospects of development activities in the field of reference materials are formulated.

Application of a method of absolute calibration relating to gas chromatography analysis of liquid hydrocarbon samples is considered. It is shown for this task that both from theoretical, and practical points of view the optimum concentration unit is mass (not molar) fraction. Information on average molar mass of the analyzed sample is necessary for the determination of analytes in liquid hydrocarbon samples in terms of mole fraction. Meanwhile, the normative documents of rather high rank (ASTM, ISO, GOST, GOST R) concerning methods of the determination of average molar weight of samples of such a kind are absent.

The paper represents general information of use of reference material (RM) of composition of toxic metal solutions and RM of composition of biological tissues which contain toxic metals (TM) when measuring the TM content in biological materials. The paper describes and analyses the approaches for preparing samples of reference materials which contain Pb, Hg, Cd, Be and TI, developed by the Institute of Toxicology Federal Bio-Medical Agency of Russia and Ural Research Institute for Metrology. When developing, approving and certification of the relevant measurement methods for TM content in biological materials it is necessary to include, as an essential condition, the requirement to use RM of composition of biological tissues which analyte is naturally built in the material matrix as a result of metabolic process. The analogical requirement should be produced when accrediting and licensing medical and biological laboratories and laboratories of chemical and analytical control.

The article deals with reference materials for moisture and bulk density of blast furnace coke for graduation of neutron moisture and density meters. Reference materials are produced from substances and materials which element content is identical to coke elemental content coke.

Actuality of the research. Development of standard samples (SS) of food colour content continues to be relevant to enhance safety and quality of food products, additives and other micro-ingredients as well as to deal with import substitution. Work objective. The objective of this work is to develop SS for the basic substance and toxic elements in the most frequently used in food technologies synthetic food colours: Tartrazine E102, Yellow Quinoline E104, Azorubine E122 and Ponseau 4R E124. Research techniques. Mass fraction of colour in the samples was determined by spectrophotometry as per 320502013 GOST Standard; colour samples for toxic elements were evaluated according to 26929-94 GOST Standard; content of lead and cadmium was determined by atomic absorption analysis defined in the GOST 30178-96, arsenic -by calorimetry as per GOST 26930-94, mercury - by flameless atomic sorption spectrometry according to MU № 5178-90, homogeneity and shelf life - in conformity with RMG 93-2009, GOST 8.531-2002 and Р 50.2.031-2003. Results. SS for the content of four food colours were developed based on the research findings. Their following metrological specification is given in the Table 6: mass fraction of the basic substance, %, fractional error limits (P = 0,95), S, %; content of toxic elements, mg/kg with fractional error limits, S, %.

Considered problematic issues of the development of reference materials (RMs) for aircraft industry. The focus is on the methods for choosing the RM chemical composition and metallographic structure, and the use of different technologies for their production with high intra- and between item homogeneity. Considered problematic issues of the RM program, shows the need to expand and optimize the range of RMs. The present work is performed within framework of the integrated research concept 2.1. "Fundamentally oriented research" ("Strategic concepts of development of materials and technologies for their processing for the period up to 2030").

Rationale. The reference material of composition with the established metrological characteristics including a certified value and an expanded uncertainty is necessary to ensure an effective accuracy and precision control of results of element composition determination in food ingredients and products. This paper represents the development of a reference material of food crop composition for selenium, nitrogen, phosphorus and potassium content. Methods. To identify the selenium the hybrid atomic absorption method was used, to identify the nitrogen and phosphorus the photometric method was used, to determine the potassium flame-photometric method was used. When determining the metrological characteristics of the reference material the Russian national instructions and recommendations MI 3174-2009 and P 50.2.058-2007 were applied. Results. Based on the research findings the reference material of Chinese cabbage composition with a certified value and an expanded uncertainty was developed: for selenium 0.044 ± 0.017 mg/kg; for nitrogen 4.09 ± 0.27 %; for phosphorus 0.69 ± 0.14 %; for potassium 2.87 ± 0.22 %.

The approaches for creating reference materials of glycine with certified values of nitrogen and base material mass fractions GSO 10272-2013 have been presented. Created certified reference material is intended for calibration and graduation of measurement equipments based on the different physical-chemical methods of analysis, as well as for check of error of measurement procedures. Besides GSO 10272-2013 can be used tor evaluating the purity of the components of medicinal preparations in pharmaceutical industry. GSO 10272-2013 will be used as an object for key comparisons in 2015.

A state standard sample (GSO) of lactic acid content to testify and control accuracy and precision of procedures for determining lactic acid weight concentration in food was developed. It goes to the making of graduation, calibration and adjustment of measuring devices. Metrological characteristics for standard sample of lactic acid content - inhomogeneity and instability errors - were determined.

The International Organization for Standardization laid down modern requirements for reference material producers (ISO 17034:2016), testing and calibration laboratories (ISO 15025:2005), stipulating the evaluation of reference material commutability in the course of their development (ISO Guide 35:2006) and use (ISO Guide 33:2006). The article deals with general issues of reference material commutability evaluation, the cases when the commutability evaluation is useful and the description of the approach, which may be used in the processing measurement results when evaluating the commutability of reference materials.

The article presents information about one of the largest in RF manufacturer of the approved types reference materials (GSO), intended for the metrological assurance of safety and quality parameters control for water, aqueous medium and different types ofproduction. It's shown measurement capabilities of the Center. It's also shown traceability schemes to primary standards and SI units for characterization results for all types of prodused CRM.

The article describes the history of creation of Russian reference materials (RMs), the stages of start-up and development of the Institute for Certified Reference Materials as a main producer of RMs of metallurgical production in Russia. The article considers the experience of the Institute for Certified Reference Materials for RMs development and metrological assurance of quantity chemical analysis based on their use.

The article deals with the main stages of the development of activities of INTEGRSO branches in the field of the development of national reference materials of petrol and petroleum products composition and properties under the Program of the metrological assurance of petroleum processing plant products. The scientific and production program of metrological assurance of test methods and control means for petrol and petroleum product composition and properties on the basis of reference materials with trademark NPO "INTEGRSO" is self-fulfilled. From 1986 more than 185 types of reference materials were developed and produced including 36 types of import-substituting reference materials.

The article presents the results of an interlaboratory experiment evaluating the differences in the results obtained by different methods of measuring of specific power of magnetic losses of sheet specimens of oriented electrical steel. Measurements were carried out both with the installation CICL-2 that implements measurement method using field coils and a standardized method with calculation of field magnitude from the current value in the magnetizing winding, and with the measuring systems with different design of yokes implementing a standardized method. The article analyzes the experimental data obtained in order to assess the comparability of measurement results for systems with different design of the closing yoke.