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Your search keyword '"Heesterbeek, TJ"' showing total 2 results
Start Over Author "Heesterbeek, TJ" Journal stem cell research

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2 results on '"Heesterbeek, TJ"'

1. Generation and characterization of human induced pluripotent stem cells (iPSCs) from three individuals without age-related macular degeneration.

Author

Koolen L, Gagliardi G, Ten Brink SCA, de Breuk A, Heesterbeek TJ, Hoyng CB, Albert S, and den Hollander AI

Subjects
Aged, Cell Line, Humans, Leukocytes, Mononuclear metabolism, Induced Pluripotent Stem Cells metabolism, Macular Degeneration genetics, Macular Degeneration metabolism
Abstract

Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. AMD is multifactorial eye disease with a strong genetic contribution. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from peripheral blood mononuclear cells of three individuals above 70 years of age without AMD. These cell lines were generated to serve as control lines for cellular studies investigating the disease mechanisms and developing therapeutic interventions for AMD., (Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.)

Published
2022
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2. Generation and characterization of human induced pluripotent stem cells (iPSCs) from three patients with age-related macular degeneration carrying rare variants in the CFH gene.

Author

Koolen L, Gagliardi G, Ten Brink SCA, de Breuk A, Heesterbeek TJ, Hoyng CB, Albert S, and den Hollander AI

Subjects
Aged, Cell Line, Complement Factor H genetics, Complement Factor H metabolism, Humans, Leukocytes, Mononuclear metabolism, Polymorphism, Single Nucleotide, Induced Pluripotent Stem Cells metabolism, Macular Degeneration genetics, Macular Degeneration metabolism
Abstract

Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. AMD is multifactorial eye disease with a strong genetic contribution. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from peripheral blood mononuclear cells of three patients with AMD carrying rare variants in the complement factor H (CFH) gene. These cell lines were generated for cellular studies investigating the disease mechanisms and developing therapeutic interventions for AMD., (Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.)

Published
2022
Full Text
View/download PDF

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