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Your search keyword '"Hong-Feng, Jiang"' showing total 2 results
Start Over Author "Hong-Feng, Jiang" Journal stem cell research
2 results on '"Hong-Feng, Jiang"'

1. The establishment of a homozygous SNTA1 knockout human embryonic stem cell line (WAe009-A-50) using the CRISPR/Cas9 system

Author

Tao Dong, Siyao Zhang, Yun Chang, Rui Bai, Youxu Jiang, Shuhong Ma, Ya'nan Li, Hong Feng Jiang, and Wen-Jing Lu

Subjects
Biology (General), QH301-705.5
Abstract

SNTA1 encodes α1-syntrophin, a scaffold protein, which is a component of the dystrophin-associated protein complex. Additionally, α1-syntrophin interacts with SCN5A and nNOS–PMCA4b complex in cardiomyocytes. SNTA1 is a susceptibility locus for arrhythmia and cardiomyopathy. We generated a homozygous SNTA1 knockout human embryonic stem cell (H9SNTA1KO) using the CRISPR/Cas9 system. H9SNTA1KO maintained pluripotency and a normal karyotype and differentiated into three germ layers in vivo.

Published
2021
Full Text
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2. The establishment of a homozygous SNTA1 knockout human embryonic stem cell line (WAe009-A-50) using the CRISPR/Cas9 system

Author

Wen-Jing Lu, Shuhong Ma, Siyao Zhang, Ya'nan Li, Yun Chang, Hong Feng Jiang, Rui Bai, Youxu Jiang, and Tao Dong

Subjects
0301 basic medicine, Scaffold protein, Human Embryonic Stem Cells, Germ layer, Biology, Cell Line, 03 medical and health sciences, 0302 clinical medicine, In vivo, Humans, CRISPR, lcsh:QH301-705.5, Embryonic Stem Cells, Cas9, Homozygote, Karyotype, Cell Biology, General Medicine, Embryonic stem cell, Cell biology, 030104 developmental biology, lcsh:Biology (General), CRISPR-Cas Systems, 030217 neurology & neurosurgery, Developmental Biology, Human embryonic stem cell line
Abstract

SNTA1 encodes α1-syntrophin, a scaffold protein, which is a component of the dystrophin-associated protein complex. Additionally, α1-syntrophin interacts with SCN5A and nNOS-PMCA4b complex in cardiomyocytes. SNTA1 is a susceptibility locus for arrhythmia and cardiomyopathy. We generated a homozygous SNTA1 knockout human embryonic stem cell (H9SNTA1KO) using the CRISPR/Cas9 system. H9SNTA1KO maintained pluripotency and a normal karyotype and differentiated into three germ layers in vivo.

Published
2021
Full Text
View/download PDF

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