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A straightforward and economical synthetic route for the preparation of cholesterol was developed from plant origin bisnoralcohol. [Display omitted] • Plant-derived cholesterol was synthesized from bisnoralcohol. • This promising route for production of cholesterol has a high overall yield. • The epicholesteorl and cholestanol were also synthesized. Currently, the market demand of the non-animal-derived cholesterol is increasing. A novel synthetic route of producing cholesterol was developed through multiple reactions from plant-sourced and commercially available bisnoralcohol (BA). The key reaction conditions, including solvents, reaction temperatures, bases and reducing agents of the route were investigated and optimized. In this straightforward synthetic pathway of cholesterol, most of the reaction steps possess high conversions with average yields of 94%, and the overall yield is up to 74% (5 steps) from the BA. The epicholesterol and were also synthesized. This promising route offers economical and efficient strategies for potential large-scale production of plant-derived cholesterol. [ABSTRACT FROM AUTHOR]

A straightforward and economical synthetic route for the preparation of ursodeoxycholic acid was developed from plant-source bisnoralcohol. • A facile route of producing ursodeoxycholic acid from plant-source BA is provided. • This promising route for production of ursodeoxycholic acid has a high yield. • This route of-fers a method for po-ten-tial large-scale pro-duc-tion of UDCA. A novel synthetic route of producing ursodeoxycholic acid (UDCA) was developed through multiple reactions from cheap and commercially available bisnoralcohol (BA). The key reaction conditions, including solvents, bases and reaction temperatures of the route were investigated and optimized. In the straightforward route for preparation of UDCA, most of the reaction steps have high conversions with average yields of 91%, and overall yield up to 59% (6 steps) from the plant-source BA. Especially in the last step of reduction and hydrolysis, there are five functional groups converted with calcd 97% per conversion in one-pot reaction. This promising route offers economical and efficient strategies for potential large-scale production of UDCA. [ABSTRACT FROM AUTHOR]