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This paper presents a general spatio-temporal model for assessing the air quality impact of environmental policies which are introduced as abrupt changes. The estimation method is based on the EM algorithm and the model allows to estimate the impact on air quality over a region and the reduction of human exposure following the considered environmental policy. Moreover, impact testing is proposed as a likelihood ratio test and the number of observations after intervention is computed in order to achieve a certain power for a minimal reduction. An extensive case study is related to the introduction of the congestion charge in Milan city. The consequent estimated reduction of airborne particulate matters and total nitrogen oxides motivates the methods introduced while its derivation illustrates both implementation and inferential issues. [ABSTRACT FROM AUTHOR]