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40 results on '"Norris, John"'

10. Aspirin: Optimal Dose in Stroke Prevention

Author

Dyken, Mark L., Barnett, H. J.M, Easton, J. Donald, Fields, William S., Fuster, Valentin, Hachinski, Vladimir, Norris, John W., and Sherman, David G.

Published
1993

11. Low-Dose Aspirin and Stroke

Author

Dyken, Mark L., Barnett, H. J.M., Easton, J. Donald, Fields, William S., Fuster, Valentin, Hachinski, Vladimir, Norris, John W., and Sherman, David G.

Published
1993

25. CHARISMA

Author

Fisher, Marc, primary, Lees, Kennedy, additional, Norris, John W., additional, and Barnett, Henry J., additional

Published
2006
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27. Carotid Plaque Pathology

Author

Fisher, Mark, primary, Paganini-Hill, Annlia, additional, Martin, Aldana, additional, Cosgrove, Michele, additional, Toole, James F., additional, Barnett, Henry J.M., additional, and Norris, John, additional

Published
2005
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30. Cervical Arterial Dissection

Author

Beletsky, Vadim, primary, Nadareishvili, Zurab, additional, Lynch, John, additional, Shuaib, Ashfaq, additional, Woolfenden, Andrew, additional, and Norris, John W., additional

Published
2003
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35. Selfotel in Acute Ischemic Stroke

Author

Davis, Stephen M., primary, Lees, Kennedy R., additional, Albers, Gregory W., additional, Diener, Hans Christoph, additional, Markabi, Sabri, additional, Karlsson, Goeril, additional, and Norris, John, additional

Published
2000
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39. Guidelines for Carotid Endarterectomy

Author

Moore, Wesley S., primary, Barnett, H.J.M., additional, Beebe, Hugh G., additional, Bernstein, Eugene F., additional, Brener, Bruce J., additional, Brott, Thomas, additional, Caplan, Louis R., additional, Day, Arthur, additional, Goldstone, Jerry, additional, Hobson, Robert W., additional, Kempczinski, Richard F., additional, Matchar, David B., additional, Mayberg, Marc R., additional, Nicolaides, Andrew N., additional, Norris, John W., additional, Ricotta, John J., additional, Robertson, James T., additional, Rutherford, Robert B., additional, Thomas, David, additional, Toole, James F., additional, Trout, Hugh H., additional, and Wiebers, David O., additional

Published
1995
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40. Cervical arterial dissection: time for a therapeutic trial?

Author

Beletsky V, Nadareishvili Z, Lynch J, Shuaib A, Woolfenden A, and Norris JW

Subjects
Adult, Anticoagulants therapeutic use, Brain Ischemia etiology, Canada, Carotid Artery, Internal, Dissection drug therapy, Carotid Artery, Internal, Dissection etiology, Disease Progression, Drug Therapy, Combination, Feasibility Studies, Female, Follow-Up Studies, Humans, Ischemic Attack, Transient etiology, Male, Middle Aged, Neck Injuries complications, Platelet Aggregation Inhibitors therapeutic use, Prospective Studies, Recurrence, Risk Factors, Stroke etiology, Survival Rate, Treatment Outcome, Vertebral Artery Dissection drug therapy, Vertebral Artery Dissection etiology, Carotid Artery, Internal, Dissection diagnosis, Vertebral Artery Dissection diagnosis
Abstract

Background and Purpose: Cervical arterial dissection is a major cause of stroke in young adults, yet despite standard treatment with anticoagulants or antiplatelet drugs, its management remains uncertain. The goal of this study was to assess the natural history of the disorder and to decide on the feasibility of a therapeutic trial., Methods: Collaborating members of the Canadian Stroke Consortium prospectively enrolled consecutively referred patients with angiographically proven acute vertebral or carotid arterial dissection. Data recorded included clinical and radiological details, recurrence of ischemic cerebral events, and medical or surgical treatment., Results: Of 116 patients, 67 had vertebral and 49 had carotid dissections, with no difference in age or sex. In 68 (59%), trauma occurred at the time of dissection. During the course of a 1-year follow-up, at least 17 patients (15%) had recurrent transient ischemic attacks, stroke, or death, mainly in the weeks immediately after the dissection. In 105 patients with complete follow-up, the event rate in those treated with anticoagulants was 8.3% and in those treated with aspirin was 12.4%, a nonsignificant difference of 4.1%. Using these data, we calculate that for a 2-arm trial (aspirin versus anticoagulants) with 80% power and 5% significance, 913 patients are needed in each group., Conclusions: From our data indicating an initial relatively high recurrence rate, a multicenter trial of anticoagulants versus aspirin involving a total of 2000 patients is feasible.

Published
2003
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