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10 results on '"Shin Hamada"'

2. Employment of patients with chronic pancreatitis in Japan

Author

Atsushi Masamune, Kiyoshi Kume, Shin Hamada, and Kazuhiro Kikuta

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Pancreatitis, business, medicine.disease, Gastroenterology
Published
2020

4. Treatments for acute pancreatitis in Japan

Author

Kazuhiro Kikuta, Atsushi Masamune, Tooru Shimosegawa, Shin Hamada, Ichiro Tsuji, and Morihisa Hirota

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Acute pancreatitis, medicine.disease, business, Gastroenterology
Published
2015

5. Prognosis of acute pancreatitis based on a nationwide survey in Japan

Author

Shin Hamada, Kazuhiro Kikuta, Atsushi Masamune, and Tooru Shimosegawa

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine, Acute pancreatitis, Computed tomography, medicine.disease, business, Intensive care medicine, Nationwide survey
Published
2014

6. A case of pancreatic tail cancer with AIP-like stromal features

Author

Naoaki Sakata, Tetsuya Takikawa, Noriaki Unno, Kazuhiro Kikuta, Eriko Nakano, Kiyoshi Kume, Fumiyoshi Fujishima, Atsushi Kanno, Jun Unno, Tooru Shimosegawa, Kazuyuki Ishida, Morihisa Hirota, Fuyuhiko Motoi, Shin Miura, Shin Hamada, Hiroyuki Ariga, Shinichi Egawa, and Atsushi Masamune

Subjects
Stromal cell, business.industry, medicine, Cancer research, Pancreatic tail, Cancer, medicine.disease, business
Published
2013

8. Perfusion CT is useful for the differential diagnosis of autoimmune pancreatitis from pancreatic cancer

Author

Atsushi Masamune, Tooru Shimosegawa, Atsushi Kanno, Shintaro Hayashi, Jun Unno, Tsutomu Chiba, Kiyoshi Kume, Tetsuya Takikawa, Masashi Tsuda, Shin Hamada, Morihisa Hirota, Shin Miura, Kazuhiro Kikuta, Hiroyuki Ariga, and Yoshihisa Tsuji

Subjects
medicine.medical_specialty, business.industry, Pancreatic cancer, medicine, Radiology, Differential diagnosis, medicine.disease, business, Perfusion, Autoimmune pancreatitis
Published
2012

10. Can findings of DMBA-induced pancreatic cancer model in mice be applied to studies of human pancreatic carcinogenesis?

Author

Tooru Shimosegawa, Atsushi Kanno, Kennichi Satoh, Shin Hamada, Kenji Kimura, and Morihisa Hirota

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, DMBA, medicine.disease, Endocrinology, Internal medicine, Pancreatic cancer, Internal Medicine, Medicine, Pancreatic carcinogenesis, business
Abstract

膵癌早期発見のためには膵発癌機構を解明することが不可欠である．そのためには，遺伝子解析も作成法も容易である動物モデルの開発が必要と考えられる．我々は化学発癌物質DMBA投与によってマウス膵発癌モデルを作成し，それがヒト膵癌研究に応用できるか否かを検討した．DMBA処理2週後からマウス膵にtubular complexが観察され，1ヶ月でPanIN類似病変，2ヶ月後3ヶ月後にかけて癌病変の形成が認められた．癌は肉腫様形態を呈したがcytokeratin陽性，vimentin, chymotrypsin陰性で膵管由来の癌と考えられた．過形成病変および癌病変において，ヒト膵癌同様，悪性度の進行に伴って，smad4発現の消失，cyclin D1, p53発現の増強，Notchシグナルの活性化が認められた．しかし，ヒトで最も初期にまた最も高頻度に異常の認められるK-ras遺伝子の変異は確認されなかった．これらの事から，本マウスモデルは，多くのヒト膵癌とは初期の発癌過程は異なるが進展過程に関与する遺伝子異常には類似性がみられ，ヒトにおける発癌過程の後期から癌進展過程の研究に適用できる可能性が示唆された．

Published
2008

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