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Objective: Evaluating the intervention effect of PC6 acupressure on chemotherapy-induced acute, delayed nausea, and vomiting in malignant tumor patients. Method: Eleven databases had been retrieved from January 2010 through January 2022. The published meta-analysis literature was hand-searched, and the language was limited to English and Chinese. The protocol of this meta-analysis was registered with PROSPERO (registration number: CRD42022323693). Two reviewers independently selected relevant eligible articles, extracted data, and evaluated the risk of bias. Meta-analysis was statistically analyzed using software RevMan 5.3. Result: Ten randomized controlled trials with 975 patients were included. Only two studies were assessed as high quality; eight studies were evaluated as moderate. Meta-analysis showed that compared with the control group, PC6 acupressure reduced the occurrence number of acute (SMD = −0.39,95CI (−0.73, −0.05) P = 0.02), delayed (SMD = −0.51, 95% CI (−0.96, −0.05) P = 0.03) nausea and acute (SMD = −0.42,95% CI (−0.79, −0.06) P = 0.02), delayed (SMD = −0.37, 95% CI (−0.77, 0.03) P = 0.07) vomiting; it reduced the severity of acute (SMD = −0.34, 95% CI (−0.57, −0.11) P = 0.004), delayed (SMD = −0.79, 95% CI (−1.33, −0.25) P = 0.004) nausea and acute (SMD = −0.51, 95% CI (−0.79, −0.23) P = 0.0004), delayed (SMD = −0.50, 95% CI (−0.84, −0.17) P = 0.003) vomiting, while it did not reduced the experience time on acute and delayed CINV. Conclusion: The meta-analysis shows the effectiveness of PC6 acupressure in preventing and treating nausea and vomiting. Large, high-quality, well-designed randomized controlled trials are needed in the future to determine the efficacy of PC6 acupressure on chemotherapy-induced nausea and vomiting. [ABSTRACT FROM AUTHOR]