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Background The aim of this study was to measure the circulating levels of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), and glucagon in patients who had undergone adjustable gastric banding (BND) or Roux-en-Y gastric bypass (RYGB) to understand the differences in glucose and insulin regulation after these procedures. Methods This was a cross-sectional study of 3 groups of women matched for age and body mass index: group 1, overweight controls (n = 13); group 2, BND (n = 10); and group 3, RYGB (n = 13). Venous blood was drawn with the patient in the fasted state and throughout a 3-hour period after a liquid meal. Results The fasting glucose level was similar between the 2 surgery groups; however, the fasting insulin concentrations were greater in the BND (10.0 μU/mL) than in the RYGB (6.2 μU/mL; P r = .66; P = .013). The glucose-dependent insulinotropic peptide levels at 30 minutes were lower in the RYGB group (20 pmol/L) than in the BND group (31 pmol/L) or overweight control group (33 pmol/L). The peak glucagon levels were similar among the 3 groups. Conclusion Exaggerated postprandial GLP-1 and blunted glucose-dependent insulinotropic peptide secretion after RYGB might contribute to the greater weight loss and improved glucose homeostasis compared with BND.

Cite this article as: John E. Connett, Sayeed Ikramuddin, Avis J. Thomas, John P. Bantle, Charles J. Billington, Keong Chong, Lee-Ming Chuang, William B. Inabnet III, Robert W. Jeffery, Judith Korner, Patricia S. Laqua, Wei-Jei Lee, Daniel B. Leslie, WITHDRAWN: A Randomized Trial Comparing Roux-en-Y Gastric Bypass to Intensive Medical Management in Obese Patients with Type 2 Diabetes Mellitus, Surgery for Obesity and Related Diseases, http://dx.doi.org/10.1016/j.soard.2012.08.011

Cite this article as: Avis J. Thomas, Heather A. Bainbridge, Joyce L. Schone, Shu-Chun Chen, Amy E. Reynolds, John E. Connett, Sayeed Ikramuddin, Wei-Jei Lee, Michael D. Jensen, Judith Korner, WITHDRAWN: Recruitment and Screening for a Randomized Trial Comparing Roux-en-Y Gastric Bypass to Intensive Medical Management for Treatment of Type 2 Diabetes, Surgery for Obesity and Related Diseases, http://dx.doi. org/10.1016/j.soard.2012.08.010