1. Fibrolamellar hepatocellular carcinoma coexistent with a hepatocellular carcinoma of common type: report of a case
- Author
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Kimihiro Nakashima, Takanori Yoshida, Kim Yi, Kazunari Okada, Michio Kobayashi, Shigeo Yokoyama, and Izuru Tada
- Subjects
Liver Cirrhosis ,Male ,medicine.medical_specialty ,Pathology ,Cirrhosis ,Carcinoma, Hepatocellular ,Tumor cells ,Gastroenterology ,Neoplasms, Multiple Primary ,Surgical oncology ,Internal medicine ,medicine ,Caudate lobe ,Humans ,neoplasms ,business.industry ,Liver Neoplasms ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,digestive system diseases ,Fibrolamellar hepatocellular carcinoma ,Hepatocellular carcinoma ,Immunohistochemistry ,Surgery ,Lateral segment ,alpha-Fetoproteins ,business - Abstract
A case of small fibrolamellar hepatocellular carcinoma (HCC) coexistent with a HCC of common type is herein reported. A 56-year-old man was diagnosed as having multi-nodular type HCC with liver cirrhosis. The serum alpha-fetoprotein (AFP) level was slightly increased. The patient underwent a partial caudate lobectomy and lateral segmentectomy. Histologically, both resected tumors were small HCCs measuring less than 2 cm in diameter. One was a fibrolamellar type located in the caudate lobe, while the other was the common type in the lateral segment of the liver. Positive immunohistochemical staining for AFP was observed in the tumor cells of the HCC of common type but was not observed in the fibrolamellar HCC. We also reviewed previously reported cases of fibrolamellar HCC in Japan, and discussed the clinicopathologic implications of this disease.
- Published
- 1993