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A novel ring-opening reaction of donor–acceptor cyclopropanes (DACs) through a one-pot three-component nucleophilic addition of amines, CS2 , and DACs has been described. New γ-dithiocarbamate dialkyl malonate skeletons were obtained in up to 97% yield. [ABSTRACT FROM AUTHOR]

A convenient, post-transformational reaction has been developed for the construction of highly diversified quinoline-fused triazolo-diazepinones featuring four diversification points by employing a catalyst-free Ugi four-component-nucleophilic substitution-intramolecular click cycloaddition sequence. This approach provides a wide scope of products with good yields and high bond-forming efficiency. [ABSTRACT FROM AUTHOR]

Reaction of chromonyl Meldrum's acid and N-substituted 2-aminobenzamides was studied in the presence of acidic and basic catalysts. The use of methanesulfonic acid as a catalyst in this reaction led to the synthesis of chromonyl quinazolinones through employing Meldrum's acid as a carbon leaving group. However, in the presence of basic catalyst, this reaction gave functionalized 2-pyridones. [ABSTRACT FROM AUTHOR]

Knoevenagel condensation reaction of an aldehyde and Meldrum's acid produces a 5-arylmethylidene Meldrum's acid, which undergoes Michael addition of a trialkyl phosphite under solvent- free conditions to afford the title compounds in good yields. [ABSTRACT FROM AUTHOR]

A novel, one-pot, and three-component synthesis of 4(3H)-quinazolinones is described. Benzyl halides are oxidized to aldehydes under mild Kornblum conditions then undergo a threecomponent reaction with isatoic anhydride and primary amines to produce 4(3H)-quinazolinones in excellent yields. [ABSTRACT FROM AUTHOR]

A multicomponent synthesis of 3,4-disubstituted N-aminopyrrolidine-2,5-diones is described. A mixture of N-isocyaniminotriphenylphosphorane, an aldimine and Meldrum's acid undergoes an addition reaction under mild conditions in aqueous THF to produce 1-amino-4-aryl-2,5-dioxo-N³-aryl-3-pyrrolidinecarboxamides diastereoselectively in good to excellent yields. ±H NMR analysis showed that the two substituents on C-3 and C-4 positions of the obtained pyrrolidine-2,5-diones are trans. [ABSTRACT FROM AUTHOR]

A one-pot and three-component synthesis of 2-aryl-5-hydroxyalkyl-1,3,4-oxadiazoles is described. N-Isocyaniminotriphenylphosphorane, an aldehyde, and a carboxylic acid undergo a 1:1:1 addition reaction under mild conditions to afford the title compounds in good yields. [ABSTRACT FROM AUTHOR]

A new and efficient CuI-catalyzed domino Knoevenagel hetero-Diels-Alder reaction of 1-oxa-1,3-butadienes with terminal unactivated acetylenes as building blocks to afford pyrano[2,3-c]pyrazoles has been developed. The products were obtained in good to high yields in most cases. Synthesis of polycyclic compounds in one-pot, with easy workup, and mild reaction conditions are advantages of our reported method. [ABSTRACT FROM AUTHOR]

A novel synthesis of 9H-pyrimido[4,5-b]indoles is described from a simple microwave-assisted reaction between oxindoles and aryl nitriles under solvent-free conditions in good to excellent yields. [ABSTRACT FROM AUTHOR]

An efficient, one-pot and multicomponent synthesis of dialkyl 5,5-dicyano-3-aryl-2-cyclopentene-1,2-dicarboxylates is described. A mixture of a phenacyl bromide, malononitrile, and a dialkyl acetylenedicarboxylate in the presence of triphenylphosphine and triethylamine undergo a smooth addition reaction in absolute ethanol at ambient temperature to afford the highly functionalized cyclopentenes in good to excellent yields. [ABSTRACT FROM AUTHOR]

An efficient and direct synthesis of naphtho[1,2-b]furans, naphtho[2,1-b]furans, and furo[3,2-c]chromenes is described. Heating a mixture of a naphthol or 4-hydroxycoumarin, an isocyanide, and an aldehyde under an argon atmosphere and solvent-free conditions afforded the title compounds in excellent yields. [ABSTRACT FROM AUTHOR]

A novel, one-pot, and three-component synthesis of dialkyl 5-(alkylamino)-1-aryl-1H-pyrazole-3,4-dicarboxylates is described. The reactive 1:1 zwitterionic intermediate, formed by the addition of isocyanides to dialkyl acetylenedicarboxylates, was trapped by hydrazinecarboxamides to afford the title compounds in good yields. [ABSTRACT FROM AUTHOR]

A novel, one-pot, three-component synthesis of β-amino acids is described. Heating an alkaline aqueous solution of a 2-aminopyridine, an aldehyde and Meldrum’s acid afforded β-amino acids in good to excellent yields. [ABSTRACT FROM AUTHOR]