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Start Over Author "Heasley, Steven E." Journal synlett
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1. A Practical Synthesis of [(1S,3S)-3-Aminocyclohexyl]methanol and 2-[(1S,3S)-3-Aminocyclohexyl]propan-2-ol, Useful Intermediates for the Preparation of Novel mPGES-1 Inhibitors.

Author

Walker, Daniel P., Heasley, Steven E., MacInnes, Allison, Anjeh, Tizah, Hwang-Fun Lu, Fobian, Yvette M., Collins, Joe T., Vazquez, Michael L., and Mao, Michael K.

Subjects
*CHEMICAL synthesis, *METHANOL, *AMINO alcohols, *CARBOCYCLIC acids, *CHIRALITY, *ANTI-inflammatory agents
Abstract

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a novel therapeutic target for the treatment of inflammation and pain. During the course of studies aimed at the identification of a suitable mPGES-1 inhibitor for clinical development, a need arose for preparing enantiomerically enriched amino alcohols (S,S)-2 and (S,S)-3. Described herein, a concise synthesis of (S,S)-2 and (S,S)-3 has been developed wherein both amino alcohols are derived from a commercially available, low-cost starting material. [ABSTRACT FROM AUTHOR]

Published
2011
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