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The synthesis of a series of novel quinoline fused imidazo[4,5-c]quinolines was accomplished by a simple, efficient, iodine–dimethyl­ sulfoxide (I2–DMSO) promoted sequential oxidative cross coupling­ followed by intramolecular cyclization of pyridoimidazole arylamines and carbonyl compounds in a one-pot reaction. Simple reaction conditions, no metal catalyst, no additives, no ligand, selective product formation and high yields are the advantages of this method.

The stereoselective total synthesis of epi-phomopsolide B, a polyhydroxy lactone natural product, has been accomplished. Starting from the commercially available diethyl l -tartrate, the synthesis­ involved an asymmetric Evans aldol approach and Still–Gennari olefination. Further, the resulting epi-phomopsolide B was screened for cytotoxicity and antimicrobial properties, and the outcome is presented.