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8 results on '"Peshkov, Vsevolod"'

2. A General Approach to Spirocyclic Piperidines via Castagnoli–Cushman Chemistry.

Author

Peshkov, Anatoly A., Makhmet, Azat, Bakulina, Olga, Kanov, Evgeny, Gainetdinov, Raul, Peshkov, Vsevolod A., Dar'in, Dmitry, and Krasavin, Mikhail

Subjects
PIPERIDINE, LACTAMS
Abstract

Unsaturated spirocyclic lactams stemming from a variant of the three-component Castagnoli–Cushman reaction successfully underwent hydrogenation to enable access to fully saturated spirocyclic lactams. The subsequent lactam reduction gave rise to 2-spiro piperidine building blocks. The latter can be further elaborated in compound libraries and, on their own, show propensity to activate trace amine-associated- receptor 1 (TAAR1), an important target for CNS disease. [ABSTRACT FROM AUTHOR]

Published
2022
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5. The Application of Multicomponent Ugi and Passerini Reactions for the One-Pot Synthesis of Pyrrolones and Butenolides.

Author

Nechaev, Anton A., Peshkov, Anatoly A., Peshkov, Vsevolod A., and Van der Eycken, Erik V.

Subjects
ORGANIC synthesis, HETEROCYCLIC compounds synthesis, BUTENOLIDES synthesis, ISOCYANIDES, TRIETHYLAMINE, CYCLOISOMERIZATION
Abstract

A new protocol for the one-pot synthesis of pyrrolones and butenolides involving an isocyanide-based multicomponent reaction (Ugi or Passerini) followed by a triethylamine-promoted cycloisomerization is described. [ABSTRACT FROM AUTHOR]

Published
2016
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6. Three-Component Reaction of 2-Oxoaldehydes, Cyclic 1,3-Dicarbonyl Compounds, and 4-Aminopyridines.

Author

Huiping Wei, Binbin Li, Wang, Gaigai, Van Hecke, Kristof, Pereshivko, Olga P., and Peshkov, Vsevolod A.

Subjects
AMINOPYRIDINES, PYRIDINE synthesis, HETEROCYCLIC compounds synthesis, ZWITTERIONS, CHEMICAL reactions
Abstract

A novel three-component reaction of 2-oxoaldehydes, cyclic 1,3-dicarbonyl compounds, and 4-aminopyridines leading to the formation of zwitterionic Michael adducts is described. [ABSTRACT FROM AUTHOR]

Published
2016
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