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3-Butadienyl-β-lactams are useful organic synthon which have efficiently been explored for the synthesis of a variety of heterocyclic systems. The present review compiles the various reports on the synthesis of 3-butadienyl-β-lactams and their explorations in the development of variety of monocyclic as well as condensed heterocyclic systems. [ABSTRACT FROM AUTHOR]

The manuscript presents an efficient method for the synthesis of various cis-azetidin-2-ones with high regio- and diastereoselectivity. This approach utilizes Kinugasa reaction involving diverse functionalized nitrones, including diaryl nitrones and α,β-unsaturated nitrones, in conjunction with acetylenic alcohols. Copper (I) serves as a catalyst to facilitate the transformation. [ABSTRACT FROM AUTHOR]

Functionalized tricyclicpyrimidinones, a class of condensed heterocyclic systems, are found in numerouspotentially active molecules having both innate as well as synthetic origin. Different researchers across the world have explored different synthetic methods for the construction of appropriately functionalized tricyclicpyrimidinones. The present review article recapitulates various reports pertaining to substituted and functionalized tricyclic pyrimidinones reported since 2000. [ABSTRACT FROM AUTHOR]

The manuscript describes an efficient, atom economical synthesis of pyrimido[4,5-b][1,4]benzodiazepin-4-ones by relatively unexplored 7-endo-trig Pictet–Spengler type cyclisations. The synthetic methdodlogy involves the synthesis of different variants of 5-arylidene-amino-3H-pyrimidines and their p-toluene sulfonic acid mediated 7-endo-trig Pictet–Spengler type cyclisations to afford biologically relavent functionalized benzodiazepine condensed pyrimidinones such as pyrimido[4,5-b][1,4]benzodiazepines in good to excellent yields (82–94%). [ABSTRACT FROM AUTHOR]

Rhodium-catalyzed intermolecular [3 + 2+2] cycloaddition reactions of bis(methylenecyclopropanes) with different alkynes are described. The rhodium-catalyzed [3 + 2+2] cycloadditions resulted in the formation of functionalized 5–7–3 spirocyclic carbocycles in moderate yields with excellent regio- and chemo-selectivity. [ABSTRACT FROM AUTHOR]