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A concise one-step synthetic method was developed to prepare (S)-3,3′-di(pyrrolidinylmethyl)-H8BINOL via Mannich-type reaction. Under the optimal reaction conditions, the yield reached 83% (by recrystallization) and 93% (by column chromatography). This new procedure has reduced the molar ratio of pyrrolidine/paraformaldehyde/(S)-H8BINOL from 58:58:1 to 3:3:1, which simplified the previously reported two-step reaction to a one-step reaction with no need for laborious operations such as cooling and solvent degassing, and avoided discharging a large amount of dioxane-containing waste water. [ABSTRACT FROM AUTHOR]

Ethyl 6-N-decyloxy-7-ethoxy-4-hydroxyquinoline-3-carboxylate has been synthesized from pyrocatechol in six steps and in 39.3% overall yield. [ABSTRACT FROM AUTHOR]

A pyrrolizidine alkaloid, (2S, 8S)-2-benzyl hexahydro-pyrrodizin-3-one, was synthesized from (L)-proline using diastereoselective benzylation as the key step. The absolute configuration of the target compound was confirmed through 2D H-H COSY and H-H NOESY spectra. [ABSTRACT FROM AUTHOR]