1. Synthesis and investigation of cytotoxicity of newN- andS,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines
- Author
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Mehmet Erdi Onan, Zeliha Gökmen, Engin Ulukaya, Didem Karakas, Nahide Gulsah Deniz, İstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Yazılım Mühendisliği Bölümü, Didem Karakaş / 0000-0002-3781-6834, Engin Ulukaya / 0000-0003-4875-5472, Karakaş Zeybek, Didem, Ulukaya, Engin, Didem Karakaş / L-6682-2018, Engin Ulukaya / K-5792-2018, Didem Karakaş / 56422040600, and Engin Ulukaya / 6602927353
- Subjects
Antifungal ,010405 organic chemistry ,medicine.drug_class ,Chemistry ,Cytotoxicity ,Organic Chemistry ,Cancer ,1,4-Naphthoquinone ,010402 general chemistry ,medicine.disease ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,Heterocyclic Thioether ,Anticancer Agent ,chemistry.chemical_compound ,medicine ,1,4-Nq - Abstract
1,4-Naphthoquinones (1,4-NQ) have been reported to possess a variety of pharma-cological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic, and anticancer effects. In this study, new N- and S,S-substituted-1,4-NQ derivatives were synthesized in excellent yields and were completely characterized by spectroscopic analysis IR, NMR (H-1 and C-13), MS and microanalysis. The cytotoxic activities of 1,4-NQ derivatives were examined against to A-549, DU145, HCT-116 and MDA-MB-231 cancer cells. Among these compounds, 2-[4-(2-furoyl)piperazine-1-yl]-3-chloro-1,4-NQ 5 and 2,3-bis(cyclobuthylsulfanyl)-1,4-NQ 17 were identified as the most potent anticancer agents with cytotoxic activity against three cell lines (breast (MDA-MB-231), prostate (DU145), colorectal (HCT-116). Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa [56964, FBA-2018-28971] This study was funded by Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa (Project number: 56964 and Project number: FBA-2018-28971). WOS:000484035200001 Q3
- Published
- 2019
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