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Your search keyword '"Naikoo, Rayees Ahmad"' showing total 4 results
Start Over Author "Naikoo, Rayees Ahmad" Journal synthetic communications
4 results on '"Naikoo, Rayees Ahmad"'

4. 7-Endo-trig Pictet–Spengler type cyclization of 5-alkylidene/arylidene-amino-3H-pyrimidin-4-ones: An efficient and diastereoselective synthesis of pyrimido[4,5-b] [1,4]benzodiazepines.

Author

Naikoo, Rayees Ahmad, Kumar, Rupesh, Singh, Parvesh, and Bhargava, Gaurav

Subjects
*BENZODIAZEPINES, *RING formation (Chemistry), *SULFONIC acids
Abstract

The manuscript describes an efficient, atom economical synthesis of pyrimido[4,5-b][1,4]benzodiazepin-4-ones by relatively unexplored 7-endo-trig Pictet–Spengler type cyclisations. The synthetic methdodlogy involves the synthesis of different variants of 5-arylidene-amino-3H-pyrimidines and their p-toluene sulfonic acid mediated 7-endo-trig Pictet–Spengler type cyclisations to afford biologically relavent functionalized benzodiazepine condensed pyrimidinones such as pyrimido[4,5-b][1,4]benzodiazepines in good to excellent yields (82–94%). [ABSTRACT FROM AUTHOR]

Published
2021
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