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The heterocyclic compounds, which include phytochemical components, offer medicinal and food characteristics that are crucial in the drug business. They are commonly used in folk medicine to heal conditions such as chilly, asthma, constipation, headache, tobacco, fever and skin issues. Most prescription medicinal products also induce other side effects, such as gastrointestinal issues. There is therefore high need for the development of new and efficient anti-diabetic medicines with fewer side effects. New forms of anti-diabetic drugs are needed continuously as diabetes is a pandemic worldwide. The heterocyclic manufactured derivatives data have comparable characteristics than natural alkaloids. More and more heterocyclic derivatives were created and synthesized to investigate their bioactivities in the previous two decades. This study enables researchers to investigate further the potential for numerous medicinal uses of these heterocyclic multilateral derivatives. [ABSTRACT FROM AUTHOR]