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Objective: General anesthesia is used in most in vitro fertilization (IVF) clinics for oocyte pick-up (OPU), however, there is no consensus on type of anesthetic agent use among clinicians performing OPU. Therefore, we aimed to evaluate the effects of propofol, ketamine, or combination of propofol and ketamine (P + K) for OPU on IVF outcome., Material and Methods: Three hundred and thirty three women (n = 333) undergoing IVF treatment were retrospectively included and were evaluated in three groups depending on whether they received propofol (n = 217), or ketamine (n = 60), or P + K (n = 56) for anesthesia during OPU., Results: Baseline characteristics and duration of anesthesia of each group were comparable except lower motile sperm percentage in the ketamine group compared to the propofol group (p = 0.002). Fertilization rate (FR) was decreased with ketamine compared to propofol (p = 0.013) and P + K (p = 0.008). After adjustment for sperm motility, this negative effect of ketamine on FR persisted. Implantation, clinical pregnancy, take-home baby rates, and oocyte retrieval parameters (number of total retrieved oocyte, metaphase II oocytes, embryo and methaphase II rate, and embryo quality) did not differ between the groups. Extended anesthesia duration (>30 min) was associated with low implantation (p = 0.04) and clinical pregnancy rates (p = 0.02)., Conclusion: Ketamine use during OPU can affect FR compared to propofol and P + K. Long durations of anesthesia also seem to decrease implantation and clinical pregnancy rates., (Copyright © 2019. Published by Elsevier B.V.)

Objective(s): The purpose of our study was to evaluate whether the inflammatory parameters of complete blood count (CBC), including white blood cell (WBC), neutrophil-to-lymphocyte-ratio (NLR), platelet-to-lymphocyte-ratio (PLR), and mean platelet volume (MPV), had potential roles in the etiopathogenesis of unexplained infertility (UI) among nonobese women. We also aimed to investigate whether there could be an association between these markers and in vitro fertilization (IVF) success among nonobese women with UI., Materials and Methods: This was a retrospective clinical trial, including a total of 246 nonobese patients undergoing IVF procedures, 121 diagnosed as UI and 125 were age and body mass index (BMI) matched infertile controls who received IVF for tubal factor and male factor. Only normoweight (BMI<25 kg/m 2 ) participants were recruited to our study to rule out the effect of obesity on inflammation. CBC parameters were evaluated before ovarian stimulation protocol., Results: All of the inflammatory parameters of CBC were distributed homogenously between groups. Platelet and lymphocyte count were positively correlated with fertilization rate (FR) among UI patients. Embryo count was positively correlated with platelet and negatively correlated with MPV. PLR was also positively correlated with luteinizing hormone on day 3 of cycle. After adjustment for age and BMI, there was a positive association between lymphocyte count and FR and a negative association between PLR and implantation among UI patients. None of the inflammatory markers of CBC were predictive for clinical pregnancy, take home baby, and clinical and biochemical abortion rates among nonobese UI patients., Conclusion: Increased levels of CBC inflammation markers may have a negative impact on IVF outcomes among nonobese women with UI., (Copyright © 2018. Published by Elsevier B.V.)