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3. “Turn-on” fluorescent dipodal chemosensor for nano-molar detection of Zn2+: Application in living cells imaging.

Author

Fegade, Umesh, Sharma, Hemant, Bondhopadhyay, Banashree, Basu, Anupam, Attarde, Sanjay, Singh, Narinder, and Kuwar, Anil

Subjects
*FLUORESCENCE, *CHEMORECEPTORS, *ZINC, *HYDRAZIDES, *CHEMICAL derivatives, *IMINES, *PHENOLS, *FLUORESCENCE spectroscopy
Abstract

Abstract: A malonohydrazide derivative bearing an imine and phenolic group was synthesized and had a high affinity and selectivity towards Zn2+. The recognition properties of receptor 1 were evaluated using absorbance and fluorescence spectroscopy. The 1:1 stoichiometry of 1.Zn2+ was confirmed from job׳s plot, mass spectra and density functional theory (DFT). The detection of Zn2+ in intracellular environment of HeLa cell through confocal microscopy was successfully applied for live cell imaging. [Copyright &y& Elsevier]

Published
2014
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